scholarly journals Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP)

2022 ◽  
Vol 9 (1) ◽  
pp. 7-16
Author(s):  
Mai Nishikawa ◽  
Naoki Ohara ◽  
Yukiko Naito ◽  
Chihiro Amma ◽  
Yoshiaki Saito ◽  
...  
Keyword(s):  
Canola Oil ◽  
Spontaneously Hypertensive Rats ◽  
Plasma Aldosterone ◽  
Hypertensive Rats ◽  
Aldosterone Level ◽  
Spontaneously Hypertensive ◽  
Testosterone Production ◽  
Plasma Aldosterone Level

Body fluid volumes in prehypertensive spontaneously hypertensive rats

1983 ◽  
Vol 244 (5) ◽  
pp. H652-H655 ◽  
Author(s):  
M. M. Mullins
Keyword(s):  
Volume Expansion ◽  
Body Fluid ◽  
Spontaneously Hypertensive Rats ◽  
Interstitial Fluid ◽  
Extracellular Fluid ◽  
Plasma Aldosterone ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto ◽  
Total Body

To ascertain the effect of aldosterone on body fluid volumes in neonatal, prehypertensive spontaneously hypertensive rats (SHR), we studied these animals at 12 days using age-matched Wistar-Kyoto (WKY) as normotensive controls. Some pups of each strain were treated with spironolactone (1.5 micrograms/g body wt) on days 10-12. Total body water (TBW, by dessication) and extracellular fluid (ECF, Na2 35SO4 space) volumes were significantly larger in SHR than in WKY, whereas plasma volumes (125I-serum albumin space) were not different. Thus the enlarged ECF was due to preferential expansion of the interstitial fluid (ISF) space. Treatment of SHR with spironolactone reduced TBW and ISF to values not different from untreated WKY and also reduced plasma volume to some extent. These results indicate 1) significant ISF volume expansion occurs in SHR prior to elevation of blood pressure, and 2) the previously observed elevation in plasma aldosterone in SHR at this age probably mediates the volume expansion.

scholarly journals Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Kenjiro Tatematsu ◽  
Daisuke Miyazawa ◽  
Yoshiaki Saito ◽  
Harumi Okuyama ◽  
Naoki Ohara
Keyword(s):  
Body Weight ◽  
Canola Oil ◽  
Spontaneously Hypertensive Rats ◽  
Body Weight Gain ◽  
Basal Diet ◽  
The Body ◽  
Control Group ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hydrogenated Oils

Abstract Background Canola oil (Can) and several vegetable oils shorten the lifespan of stroke-prone spontaneously hypertensive rats (SHRSP). Although similar lifespan shortening has been reported for partially hydrogenated Can, the efficacy of fully hydrogenated oils on the lifespan remains unknown. The present study aimed to investigate the lifespan of SHRSP fed diets containing 10 % (w/w) of fully hydrogenated Can (FHCO) or other oils. Methods Survival test: Upon weaning, male SHRSP were fed a basal diet for rodents mixed with one of the test oils —i.e., FHCO, Can, lard (Lrd), and palm oil (Plm) throughout the experiment. The animals could freely access the diet and drinking water (water containing 1 % NaCl), and their body weight, food intake, and lifespan were recorded. Biochemical analysis test: Male SHRSP were fed a test diet with either FHCO, Can, or soybean oil (Soy) under the same condition, except to emphasize effects of fat, that no NaCl loading was applied. Soy was used as a fat source in the basal diet and was set the control group. Blood pressures was checked every 2 weeks, and serum fat levels and histological analyses of the brain and kidney were examined after 7 or 12 weeks of feeding. Results During the survival study period, the food consumption of FHCO-fed rats significantly increased (15–20 % w/w) compared with that of rats fed any other oil. However, the body weight gain in the FHCO group was significantly less (10–12 %) than that in the control group at 9–11 weeks old. The FHCO (> 180 days) intervention had the greatest effect on lifespan, followed by the Lrd (115 ± 6 days), Plm (101 ± 2 days), and Can (94 ± 3 days) diets. FHCO remarkably decreased the serum cholesterol level compared with Can and the systolic blood pressure from 12 to 16 weeks of age. In addition, while some rats in the Can group exhibited brain hemorrhaging and renal dysfunction at 16 weeks old, no symptoms were observed in the FHCO group. Conclusion This current study suggests that complete hydrogenation decreases the toxicity of Can and even prolongs the lifespan in SHRSP.

Plasma aldosterone concentrations in neonatal spontaneously hypertensive rats

Life Sciences ◽  
1982 ◽  
Vol 31 (24) ◽  
pp. 2751-2755 ◽  
Author(s):  
Margaret M. Mullins ◽  
Leonard I. Kleinman ◽  
Paul T. Russell ◽  
Laxmi S. Srivastava
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Plasma Aldosterone ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document