scholarly journals Evaluation of cytotoxic potential of cored soft contact lenses with adsorbed active ingredients from over-the-counter eye drops

2012 ◽  
Vol 37 (3) ◽  
pp. 639-643 ◽  
Author(s):  
Nobuhito Tabuchi ◽  
Manabu Hattori ◽  
Makiko Shimizu ◽  
Misao Koide ◽  
Hiroshi Yamazaki
Keyword(s):  
Contact Lenses ◽  
Eye Drops ◽  
Active Ingredients ◽  
Cytotoxic Potential ◽  
Soft Contact ◽  
Over The Counter ◽  
Soft Contact Lenses

The Effect of Photoinitiator Concentration on the Physicochemical Properties of Hydrogel Contact Lenses

2014 ◽  
Vol 679 ◽  
pp. 118-127 ◽  
Author(s):  
Deirdre M. McElroy ◽  
Luke M. Geever ◽  
Clement L. Higginbotham ◽  
Sinead M. Devery
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Contact Lens ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Hydrogel soft contact lenses have been investigated as delivery systems for ophthalmic drug products in response to the need for more efficient ophthalmic drug delivery systems. Ocular drugs delivered via eye drops have a low residence time in the eye resulting in as low as 5% bioavailability of the therapeutic agent. This study investigates the effect of varying concentrations of the photoinitiator diphenyl (2,4,6-trimethylbenzoyl)-phosphine oxide (TPO) on the physicochemical properties of hydrogel soft contact lenses for ophthalmic drug delivery purposes. Contact lens samples were synthesised via photopolymerisation with a range of initiator concentration. Gel fraction and swelling results indicated that increasing the photoinitiator concentration increased the efficiency of the gel network and reduced the water content of contact lens samples. Fourier transform infra-red spectroscopy (FTIR) analysis was employed to confirm polymerisation of the lenses and also indicated the presence of residual photoinitiator in lenses with higher TPO concentrations.

Changes in visual quality with soft contact lenses after the instillation of hyaluronic acid eye drops

2021 ◽  
pp. 101471
Author(s):  
Carlos Carpena-Torres ◽  
Cristina Pastrana ◽  
Candela Rodríguez-Pomar ◽  
María Serramito ◽  
Laura Batres ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Contact Lenses ◽  
Visual Quality ◽  
Eye Drops ◽  
Soft Contact ◽  
Soft Contact Lenses

scholarly journals Acanthoamoeba Keratitis Induced by a Therapeutic, Soft Contact Lens: Diagnosis via Gram Staining

2021 ◽  
Vol 20 (4) ◽  
pp. 177-181
Author(s):  
Sun Young Lee ◽  
Yang Kyung Cho
Keyword(s):  
Contact Lenses ◽  
Antimicrobial Prophylaxis ◽  
Final Diagnosis ◽  
Acanthamoeba Keratitis ◽  
Eye Drops ◽  
Soft Contact ◽  
Persistent Epithelial Defect ◽  
Soft Contact Lenses ◽  
Gram Staining ◽  
History Of

Purpose: We report two cases of Acanthamoeba keratitis diagnosed by Gram staining in patients who had recently worn therapeutic, soft contact lenses and had no history of lens use for visual correction.Case summary: The first patient was initially diagnosed with suspected mixed bacterial or fungal keratitis before a final diagnosis of Acanthamoeba keratitis was confirmed by Gram staining of a corneal smear. The second patient was initially diagnosed with a persistent epithelial defect caused by an earlier lid injury inflicted by a metallic foreign body, and then with a suspected mixed infection combined with herpetic uveitis. The patient was finally diagnosed with Acanthamoeba keratitis by Gram staining of a corneal smear. Both cases were treated with polyhexamethylene biguanide and chlorhexidine.Conclusions: Therapeutic, soft contact lenses are used to enhance corneal, epithelial wound healing in conjunction with antimicrobial prophylaxis. However, application of such a lens to a diseased cornea may predispose to the development of microbial keratitis caused by microorganisms resistant to the usual, prophylactic, antimicrobial eye drops. Therapeutic, soft contact lenses are associated with a risk of Acanthamoeba keratitis; early diagnosis is important. Gram staining of a corneal smear is useful in this context. Acanthamoeba is not eradicated by empirical broad-spectrum antimicrobials.

scholarly journals Soft Contact Lenses as Drug Delivery Systems: A Review

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5577
Author(s):  
Iwona Rykowska ◽  
Iwona Nowak ◽  
Rafał Nowak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Interdisciplinary Studies ◽  
Eye Drops ◽  
Innovative Drug ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages

This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.

Peculiarities of cultivation of the monolayer of fetal fibroblasts on the soft contact lenses, with contain the collagen

2009 ◽  
Vol 21 (5) ◽  
pp. 46-50
Author(s):  
N. Pasechnikova ◽  
◽  
G. Drozhzhina ◽  
O. Ivanova ◽  
I. Nasinnik ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Fetal Fibroblasts

Modification of therapeutic silicone-hydrogel soft contact lenses

2016 ◽  
Vol 16 (3) ◽  
pp. 117-120 ◽  
Author(s):  
T.N. Safonova ◽  
◽  
I.A. Novikov ◽  
V.I. Boev ◽  
O.V. Gladkova ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Soft Contact ◽  
Silicone Hydrogel ◽  
Soft Contact Lenses

scholarly journals Myopia Control with Combination Low-Dose Atropine and Peripheral Defocus Soft Contact Lenses: A Case Series

2021 ◽  
pp. 548-554
Author(s):  
Nir Erdinest ◽  
Naomi London ◽  
Nadav Levinger ◽  
Yair Morad
Keyword(s):  
Low Dose ◽  
Contact Lenses ◽  
Case Series ◽  
Concentric Circle ◽  
Retrospective Case ◽  
Soft Contact ◽  
Myopia Progression ◽  
Soft Contact Lenses ◽  
Center Distance ◽  
Myopia Control

The goal of this retrospective case series is to demonstrate the effectivity of combination low-dose atropine therapy with peripheral defocus, double concentric circle design with a center distance soft contact lenses at controlling myopia progression over 1 year of treatment. Included in this series are 3 female children aged 8–10 years with progressing myopia averaging −4.37 ± 0.88 D at the beginning of treatment. Their average annual myopic progression during the 3 years prior to therapy was 1.12 ± 0.75 D. They had not attempted any myopia control treatments prior to this therapy. The children were treated with a combination of 0.01% atropine therapy with spherical peripheral defocus daily replacement soft lenses MiSight<sup>®</sup> 1 day (Cooper Vision, Phoenix, AZ, USA). They underwent cycloplegic refraction, and a slit-lamp evaluation every 6 months which confirmed no adverse reactions or staining was present. Each of the 3 children exhibited an average of 0.25 ± 0.25 D of myopia progression at the end of 1 year of treatment. To the best of the authors’ knowledge, this is the first published study exhibiting that combining low-dose atropine and peripheral defocus soft contact lenses is effective at controlling children’s moderate to severe myopia progression during 1 year of therapy.

Sign in / Sign up

Export Citation Format

Share Document