Role of Denitration in Pharmacokinetics and Pharmacodynamics of Organic Nitrates.

Tomomi HATANAKA

doi:10.2133/dmpk.16.22

Pharmacokinetics and Pharmacodynamics of Meloxicam in East Asian Populations: The Role of Ethnicity on Drug Response

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12259 ◽

2017 ◽

Vol 6 (12) ◽

pp. 823-832 ◽

Cited By ~ 4

Author(s):

Takahiko Aoyama ◽

Yoshimasa Ishida ◽

Masato Kaneko ◽

Aoi Miyamoto ◽

Yoshiro Saito ◽

...

Keyword(s):

Drug Response ◽

East Asian ◽

Pharmacokinetics And Pharmacodynamics ◽

Asian Populations

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Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients

Investigational New Drugs ◽

10.1007/s10637-014-0178-2 ◽

2014 ◽

Vol 33 (1) ◽

pp. 257-268 ◽

Cited By ~ 34

Author(s):

C. Narjoz ◽

A. Cessot ◽

A. Thomas-Schoemann ◽

J. L. Golmard ◽

O. Huillard ◽

...

Keyword(s):

Cancer Patients ◽

Lean Body Mass ◽

Body Mass ◽

Pharmacokinetics And Pharmacodynamics

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The Role of Pharmacokinetics and Pharmacodynamics in the Development of Biotech Drugs

Pharmacokinetics and Pharmacodynamics of Biotech Drugs ◽

10.1002/9783527609628.ch1 ◽

2006 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Bernd Meibohm

Keyword(s):

Pharmacokinetics And Pharmacodynamics

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The increasing challenge of the possible impact of ethnicity on psychopharmacology

CNS Spectrums ◽

10.1017/s1092852920000073 ◽

2020 ◽

pp. 1-10

Author(s):

Donatella Marazziti ◽

Federico Mucci ◽

Maria T. Avella ◽

Laura Palagini ◽

Marly Simoncini ◽

...

Keyword(s):

Side Effects ◽

Ethnic Differences ◽

Therapeutic Option ◽

Side Effect Profile ◽

Limited Data ◽

Pharmacokinetics And Pharmacodynamics ◽

Cultural Stereotypes ◽

Intrinsic Factors ◽

Psychopharmacological Treatment

Abstract Ethnic differences may significantly influence the outcome of psychopharmacological treatment, in terms of prescription, adherence, clinical response, emergence of side effects, as well as pharmacokinetics and pharmacodynamics. The purpose of this review was to explore the available literature in order to provide general suggestions to help clinicians in choosing the best therapeutic option for patients, taking into account ethnicity. Although findings are sometimes controversial, the overall published studies suggest that ethnicities other than Caucasians tend to show a lower response to antidepressants and a reduced compliance. Africans tend to be more prescribed with antipsychotics, probably due to cultural stereotypes, except with clozapine, probably for their chronic benign neutropenia. Asians usually require less antipsychotic dosages than Caucasians. The differential response and side effect profile of antidepressants and antipsychotics have been related to individual intrinsic factors, to genetic make-up, but also to cultural and contextual variables. Interestingly, albeit limited data suggest ethnic-related genetic heterogeneity at the level of the serotonin transporters, the cytochromes and some neuroreceptors. Taken together, no conclusive findings are available about the role and impact of ethnicity in psychopharmacology. One of the main problems is that the majority of the studies in psychopharmacology have been conducted on Caucasians, so that there is an urgent need to have data in other populations. Furthermore, in the era of precision medicine, the role of ethnicity may be also supported by genetic analysis.

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Recent advances in the analysis of nanoparticle-protein coronas

Nanomedicine ◽

10.2217/nnm-2019-0381 ◽

2020 ◽

Vol 15 (10) ◽

pp. 1037-1061

Author(s):

Muhammad Ovais ◽

Susheel Kumar Nethi ◽

Saleem Ullah ◽

Irshad Ahmad ◽

Sudip Mukherjee ◽

...

Keyword(s):

Protein Corona ◽

Recent Decade ◽

The Body ◽

Pharmacokinetics And Pharmacodynamics ◽

Physiological Factors ◽

Characterization Methods ◽

Biological Fate ◽

Circulation Distribution ◽

The Impact

In spite of radical advances in nanobiotechnology, the clinical translation of nanoparticle (NP)-based agents is still a major challenge due to various physiological factors that influence their interactions with biological systems. Recent decade witnessed meticulous investigation on protein corona (PC) that is the first surrounds NPs once administered into the body. Formation of PC around NP surface exhibits resilient effects on their circulation, distribution, therapeutic activity, toxicity and other factors. Although enormous literature is available on the role of PC in altering pharmacokinetics and pharmacodynamics of NPs, understanding on its analytical characterization methods still remains shallow. Therefore, the current review summarizes the impact of PC on biological fate of NPs and stressing on analytical methods employed for studying the NP-PC.

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