Recent advances in the analysis of nanoparticle-protein coronas

Nanomedicine ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. 1037-1061
Author(s):  
Muhammad Ovais ◽  
Susheel Kumar Nethi ◽  
Saleem Ullah ◽  
Irshad Ahmad ◽  
Sudip Mukherjee ◽  
...  
Keyword(s):  
Protein Corona ◽  
Recent Decade ◽  
The Body ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Physiological Factors ◽  
Characterization Methods ◽  
Biological Fate ◽  
Circulation Distribution ◽  
The Impact

In spite of radical advances in nanobiotechnology, the clinical translation of nanoparticle (NP)-based agents is still a major challenge due to various physiological factors that influence their interactions with biological systems. Recent decade witnessed meticulous investigation on protein corona (PC) that is the first surrounds NPs once administered into the body. Formation of PC around NP surface exhibits resilient effects on their circulation, distribution, therapeutic activity, toxicity and other factors. Although enormous literature is available on the role of PC in altering pharmacokinetics and pharmacodynamics of NPs, understanding on its analytical characterization methods still remains shallow. Therefore, the current review summarizes the impact of PC on biological fate of NPs and stressing on analytical methods employed for studying the NP-PC.

scholarly journals Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis

2021 ◽  
Vol 22 (11) ◽  
pp. 5843
Author(s):  
Chloé Turpin ◽  
Aurélie Catan ◽  
Olivier Meilhac ◽  
Emmanuel Bourdon ◽  
François Canonne-Hergaux ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
The Body ◽  
Diabetic Patients ◽  
Special Focus ◽  
Plaque Progression ◽  
Cell Dysfunction ◽  
Circulating Cells ◽  
The Impact ◽  
Progression Of Atherosclerosis

The development and progression of atherosclerosis (ATH) involves lipid accumulation, oxidative stress and both vascular and blood cell dysfunction. Erythrocytes, the main circulating cells in the body, exert determinant roles in the gas transport between tissues. Erythrocytes have long been considered as simple bystanders in cardiovascular diseases, including ATH. This review highlights recent knowledge concerning the role of erythrocytes being more than just passive gas carriers, as potent contributors to atherosclerotic plaque progression. Erythrocyte physiology and ATH pathology is first described. Then, a specific chapter delineates the numerous links between erythrocytes and atherogenesis. In particular, we discuss the impact of extravasated erythrocytes in plaque iron homeostasis with potential pathological consequences. Hyperglycaemia is recognised as a significant aggravating contributor to the development of ATH. Then, a special focus is made on glycoxidative modifications of erythrocytes and their role in ATH. This chapter includes recent data proposing glycoxidised erythrocytes as putative contributors to enhanced atherothrombosis in diabetic patients.

scholarly journals The confidence delusion: A sociological exploration of participants’ confidence in sport-for-development

2018 ◽  
Vol 55 (4) ◽  
pp. 383-398
Author(s):  
David S Scott
Keyword(s):  
Personal Development ◽  
The Body ◽  
Individual Interviews ◽  
Everyday Lives ◽  
Sport For Development ◽  
Development Capacity ◽  
The Social ◽  
Ethnographic Methodology ◽  
The Impact

Although sport is widely utilised as a tool for personal development, capacity building, and fostering peace, there are still numerous theoretical gaps in our knowledge about how sport influences individuals’ identities, and how this translates into their everyday lives. Within the academic literature there has been seemingly little focus placed upon participants’ emotional and embodied accounts of their sport-for-development (SfD) experiences. This paper uses phenomenologically-inspired theory to explore individuals’ lived experiences of a SfD course, and their descriptions of the social interactions and feelings of confidence they encountered, in order to address this lack of experiential data. An ethnographic methodology was used to collect data through four sports leadership course observations, and cyclical interviews over 4–10 months with eleven course attendees, plus individual interviews with five tutors. Participants’ understandings of their course experiences and the subsequent influence these understandings had on their lives were described through their use of the term confidence. A further phenomenological and sociological interrogation of this term enabled confidence to be seen as being experienced as a ‘frame’ and ‘through the body’ by participants. This study provides original conceptualisations of confidence in relation to participants’ SfD experiences, as well as important discussions regarding the role of emotions and embodiment in understanding the impact of SfD on participants’ everyday lives.

scholarly journals Silver Nanoparticles as Potential Antiviral Agents

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2034
Author(s):  
Zubair Ahmed Ratan ◽  
Fazla Rabbi Mashrur ◽  
Anisha Parsub Chhoan ◽  
Sadi Md. Shahriar ◽  
Mohammad Faisal Haidere ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Potential Role ◽  
Viral Infections ◽  
Antiviral Agents ◽  
Host Cells ◽  
Characterization Methods ◽  
New Horizons ◽  
Bacteria And Fungi ◽  
The Impact

Since the early 1990s, nanotechnology has led to new horizons in nanomedicine, which encompasses all spheres of science including chemistry, material science, biology, and biotechnology. Emerging viral infections are creating severe hazards to public health worldwide, recently, COVID-19 has caused mass human casualties with significant economic impacts. Interestingly, silver nanoparticles (AgNPs) exhibited the potential to destroy viruses, bacteria, and fungi using various methods. However, developing safe and effective antiviral drugs is challenging, as viruses use host cells for replication. Designing drugs that do not harm host cells while targeting viruses is complicated. In recent years, the impact of AgNPs on viruses has been evaluated. Here, we discuss the potential role of silver nanoparticles as antiviral agents. In this review, we focus on the properties of AgNPs such as their characterization methods, antiviral activity, mechanisms, applications, and toxicity.

scholarly journals Racism, racial life events and mental ill health

2001 ◽  
Vol 7 (5) ◽  
pp. 343-349 ◽  
Author(s):  
Dinesh Bhugra ◽  
Oyedeji Ayonrinde
Keyword(s):  
Psychiatric Disorders ◽  
Life Events ◽  
Common Mental Disorders ◽  
The Body ◽  
Mental Illnesses ◽  
Positive Life Events ◽  
Minority Ethnic Groups ◽  
Different Cultures ◽  
The Impact

The association of life events with the onset of various psychiatric disorders is well-known. The body of evidence has highlighted the impact of negative or positive life events on the genesis of common mental disorders, especially depression. These findings have been replicated across different cultures, although the impact of different life events varies between cultures. In addition, the roles of chronic difficulties (defined in Life events and psychiatric disorders, below) and resulting ongoing chronic stress have been shown to contribute to vulnerability to certain mental illnesses. However, data on the impact of life events, especially those perceived as racial, on members of minority ethnic groups are rather sparse. The questions that need to be addressed concern the perception of life events as racial, the role of pervasive and perceived institutional and individual racism, and chronic difficulties.

scholarly journals A Conceptual Model Proposal: Universities as Culture Change Agents for Sustainable Development

2020 ◽  
Vol 12 (11) ◽  
pp. 4635 ◽  
Author(s):  
Małgorzata Dzimińska ◽  
Justyna Fijałkowska ◽  
Łukasz Sułkowski
Keyword(s):  
Sustainable Development ◽  
Literature Review ◽  
Conceptual Model ◽  
Culture Change ◽  
Change Agents ◽  
The Body ◽  
Quality Culture ◽  
The University ◽  
The Impact

This paper aims to propose a conceptual model that synthesizes the existing findings concerning universities as culture change agents for sustainable development. The model could serve as a guidance on how universities might get involved in the pro-SD activities. It also underlines the prerequisite of the quality culture that should be introduced within all the activities of universities to successfully act as culture change agents for SD. This paper builds upon the holistic and inter-disciplinary approach to demonstrate that SD does not happen in isolation and that the role of universities in its creation is significant. This study includes a literature review to contextualize the impact of universities on culture and their potential role in SD. The conclusions stemming from the literature review materialize in the proposal of the conceptual model of the university as the culture change agent for SD. The elaborated framework responds to the need for greater clarity, ordering and systematization of the role of universities in the processes of initiating, promoting and modelling the SD-oriented changes while appreciating the role of culture as an enabler, means of social change and a result of SD-focused interventions. The paper contributes to the body of knowledge by offering a novel perspective on the assumed interrelations between university, its quality culture, university main operations such as education, research and engagement with the society as well as the culture and the agency of stakeholders in the context of meeting the world’s current demands without compromising the needs of future generations.

scholarly journals What goes up must come down Biomechanical impact analysis of jumping locusts

2017 ◽  
Author(s):  
Simon V. Reichel ◽  
Susanna Labisch ◽  
Jan-Henning Dirks
Keyword(s):  
Impact Analysis ◽  
Schistocerca Gregaria ◽  
Impact Damage ◽  
Landing Site ◽  
The Body ◽  
Adhesive Pads ◽  
Degree Of Control ◽  
Free Falling ◽  
The Impact

AbstractMany insects are able to precisely control their jumping movements. Previous studies have shown that many falling insects have some degree of control of their landing-orientation, indicating a possible significant biomechanical role of the exoskeleton in air righting mechanisms. Once in the air, the properties of the actual landing site are almost impossible to predict. Falling insects thus have to cope mostly with the situation at impact. What exactly happens at the impact? Do locusts actively ‘prepare for landing’ while falling, or do they just ‘crash’ into the substrate?Detailed impact analyses of free falling Schistocerca gregaria locusts show that most insects typically crashed onto the substrate. There was no notable impact-reducing behaviour (protrusion of legs, etc.). Independent of dropping angle, both warm and cooled locusts mostly fell onto head and thorax first. Our results also show that alive warm locusts fell significantly faster than inactive or dead locusts. This indicates a possible tradeoff between active control vs. reduced speed. Looking at the morphology of the head-thorax connection in locusts, we propose that the anterior margin of the pronotum might function as a ‘toby collar’ structure, reducing the risk of impact damage to the neck joint. Interestingly, at impact alive insects also tended to perform a bending movement of the body.This biomechanical adaptation might reduce the rebound and shorten the time to recover. The adhesive pads also play an important role to reduce the time to recover by anchoring the insect to the substrate.

scholarly journals Integrated Bioinformatics Data Analysis and Experimental Studies Reveals Prognostic Significance of ALDH Family in Endometria Cancer

2021 ◽  
Author(s):  
Zhou-Tong Dai ◽  
Yuan Xiang ◽  
Xing-Hua Liao
Keyword(s):  
Cell Lines ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Experimental Studies ◽  
Female Reproductive Tract ◽  
The Body ◽  
Mouse Tumor ◽  
The Impact

Abstract Background Uterine Corpus Endometrial Cancer (UCEC) is one of the three common malignant tumors of the female reproductive tract. According to reports, the cure rate of early UCEC can reach 95%. Therefore, the development of prognostic markers will help UCEC patients to find the disease earlier and develop treatment earlier. The ALDH family was first discovered to be the essential gene of the ethanol metabolism pathway in the body. Recent studies have shown that ALDH can participate in the regulation of cancer. Methods We used the gene profile data of 33 cancers in the TCGA database to analyze the expression and survival of the ALDH family. GO, KEGG, PPI multiple functional analysis was used to predict the regulatory role of ALDH family in cancer. In addition, using CCK-8, colony formation, nude mouse tumor formation and other methods, the in vitro function of UCEC cancer cell lines was tested to further confirm the key role of ALDH2 expression in the proliferation of UCEC cell lines. Finally, Lasso and Cox regression methods were used to establish an overall survival prognosis model based on ALDH2 expression. Result In our research, we explored the expression of ALDH family in 33 cancers. It was found that ALDH2 was abnormally expressed in UCEC. Besides, in vivo and in vitro experiments were conducted to explore the effect of ALDH2 expression on the proliferation of UCEC cell lines. Meanwhile, the change of its expression is not due to gene mutations, but is regulated by miR-135-3p. At the same time, the impact of ALDH2 changes on the survival of UCEC patients is deeply discussed. Finally, a nomogram for predicting survival was constructed, with a C-index of 0.798 and AUC of 0.764. Conclusion This study suggests that ALDH2 may play a crucial role in UCEC progression and has the potential as a prognostic biomarker of UCEC.

Water in Students’ Life and its Impact on their Health

2021 ◽  
Vol 63 (2) ◽  
pp. 99-104
Author(s):  
Grygoriy P. Griban ◽  
Olena V. Filatova ◽  
Anatolii I. Bosenko ◽  
Ganna V. Tamozhanska ◽  
Andrii M. Lytvynenko ◽  
...  
Keyword(s):  
Water Balance ◽  
Water Consumption ◽  
Health Indicators ◽  
The Body ◽  
High Quality ◽  
National University ◽  
Quality Water ◽  
The Impact ◽  
Positive Effect

Aim: Is to study the role of water in the life of students and to investigate the impact of its quality on the health of students who did sports. Materials and Methods: The study was conducted at Polissya National University (Zhytomyr, Ukraine) in 2018-2020. Thus, 509 students between the ages of 17 and 23 who did not do sports and 317 student-athletes were surveyed. The level of students’ health was examined according to the methodology of G.L. Apanasenko. Results: It was found that the majority of students who did not do sport (97.5% of males and 96.7% of females) did not stick to the water consumption schedule, while 50.8% of males and 52.2% of females who did sport followed strict norms of the water consumption schedule to maintain water balance. According to most health indicators, students-athletes had better average values of the studied indicators than those students did not do sport. Conclusions: Water plays an important role in the lives of students and especially those students who do sport. High-quality water, sticking to water consumption schedule, especially during prolonged physical exercise and at high temperatures have a positive effect on the body and improve the health of students.

Whither the Culture War?

2015 ◽  
Author(s):  
John Dombrink
Keyword(s):  
Republican Party ◽  
Millennial Generation ◽  
Body Politic ◽  
The Body ◽  
Culture War ◽  
Strategic Plans ◽  
The Impact ◽  
Social Conservatives

This chapter concludes the book by looking at his re-election four years later, on November 6, 2012. I present data on the impact of the millennial generation and the rise of the progressive “ascendant majority” (and issues such as contraception); the suggestion of strategic plans and “rebranding” of the Republican Party, and the internecine struggles that has produced; an analysis of the role of polarization in the body politic; and the conclusion, which analyzes these elements and predicts the complications of populism (including “libertarian populism”), the reduced salience and role of social conservatives, and the end, finally, of the potency and relevance of “Reagan Democrats.”

The impact of entrepreneurship education on innovative start-up intention: the mediating role of entrepreneurial mind-sets

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Rami Hanandeh ◽  
Sakher M.A. Alnajdawi ◽  
Ammar Almansour ◽  
Hamzah Elrehail
Keyword(s):  
University Students ◽  
Educational Institution ◽  
Entrepreneurship Education ◽  
The Body ◽  
Equation Modeling ◽  
Content Type ◽  
Mediating Role ◽  
Start Up ◽  
The Impact

PurposeEntrepreneurship education at universities aims to create entrepreneurial thinking and spread the culture of entrepreneurial awareness, skills and attitudes to students to stimulate their entrepreneurship intentions as graduates. This study investigates the impact of entrepreneurship education on innovative start-up intention as well as the mediating role of entrepreneurial mind-sets of university students.Design/methodology/approachStructural equation modeling (SEM) was used for analysis with (n = 204) valid questionnaires collected from university students.FindingsThe main findings show that entrepreneurial mind-sets mediate the relationship between entrepreneurship education and innovative start-up intention.Originality/valueThis study contributes to the body of knowledge by its application in a higher educational institution and enriches the literature with new evidence that entrepreneurship education could enhance innovative start-up intention.

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