Roles of the Hypoximir microRNA-424/322 on Acute Hypoxia and Hypoxia-Induced Pulmonary Vascular Leakage

2018 ◽  
Author(s):  
Shih-Hung Tsai ◽  
Po-Hsun Huang ◽  
Yu-Juei Hsu ◽  
Yen-Wen Chen ◽  
Jen-Chun Wang ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Vascular Leakage

Roles of the hypoximir microRNA‐424/322 in acute hypoxia and hypoxia‐induced pulmonary vascular leakage

2019 ◽  
Vol 33 (11) ◽  
pp. 12565-12575 ◽  
Author(s):  
Shih‐Hung Tsai ◽  
Po‐Hsun Huang ◽  
Hsiao‐Ya Tsai ◽  
Yu‐Juei Hsu ◽  
Yen‐Wen Chen ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Vascular Leakage

scholarly journals Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26

Blood ◽  
2006 ◽  
Vol 108 (5) ◽  
pp. 1602-1610 ◽  
Author(s):  
Holger K. Eltzschig ◽  
Marion Faigle ◽  
Simone Knapp ◽  
Jorn Karhausen ◽  
Juan Ibla ◽  
...  
Keyword(s):  
Adenosine Deaminase ◽  
Acute Hypoxia ◽  
Fold Increase ◽  
Vascular Leakage ◽  
Metabolic Adaptation ◽  
Neutrophil Accumulation ◽  
Surface Binding ◽  
In Vivo Models

Extracellular levels of adenosine increase during hypoxia. While acute increases in adenosine are important to counterbalance excessive inflammation or vascular leakage, chronically elevated adenosine levels may be toxic. Thus, we reasoned that clearance mechanisms might exist to offset deleterious influences of chronically elevated adenosine. Guided by microarray results revealing induction of endothelial adenosine deaminase (ADA) mRNA in hypoxia, we used in vitro and in vivo models of adenosine signaling, confirming induction of ADA protein and activity. Further studies in human endothelia revealed that ADA-complexing protein CD26 is coordinately induced by hypoxia, effectively localizing ADA activity at the endothelial cell surface. Moreover, ADA surface binding was effectively blocked with glycoprotein 120 (gp120) treatment, a protein known to specifically compete for ADA-CD26 binding. Functional studies of murine hypoxia revealed inhibition of ADA with deoxycoformycin (dCF) enhances protective responses mediated by adenosine (vascular leak and neutrophil accumulation). Analysis of plasma ADA activity in pediatric patients with chronic hypoxia undergoing cardiac surgery demonstrated a 4.1 ± 0.6-fold increase in plasma ADA activity compared with controls. Taken together, these results reveal induction of ADA as innate metabolic adaptation to chronically elevated adenosine levels during hypoxia. In contrast, during acute hypoxia associated with vascular leakage and excessive inflammation, ADA inhibition may serve as therapeutic strategy.

Desintegration of brain regulatory mechanisms under acute hypoxia

2007 ◽  
Author(s):  
S. I. Soroko ◽  
S. S. Bekshaev ◽  
V. P. Rozhkov
Keyword(s):  
Acute Hypoxia ◽  
Regulatory Mechanisms

Relation between intestinal iNOS activation, epithelial cell viability and vascular leakage following Helicobacter pylori endotoxin challenge

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
Z Szepes ◽  
É Morschl ◽  
J Egresits ◽  
F László ◽  
J Lonovics
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cell ◽  
Cell Viability ◽  
Vascular Leakage ◽  
Endotoxin Challenge

Continuous Adaptation of Rats to Hypobaric Hypoxia Prevents Stressor Hyperglycemia and Optimizes Mitochondrial Respiration in Acute Hypoxia

2013 ◽  
Vol 4 (2) ◽  
pp. 137-147
Author(s):  
Vladimir I. Portnichenko ◽  
Valentina I. Nosar ◽  
Alla M. Sydorenko ◽  
Alla G. Portnychenko ◽  
Irina N. Mankovska
Keyword(s):  
Mitochondrial Respiration ◽  
Hypobaric Hypoxia ◽  
Acute Hypoxia

Delayed and prolonged vascular leakage in inflammation: the effects of dehydromonocrotaline on blood vessels in the rat cremaster

Pathology ◽  
1976 ◽  
Vol 8 (1) ◽  
pp. 7-20 ◽  
Author(s):  
J.V. Hurley ◽  
Marjorie V. Jago
Keyword(s):  
Blood Vessels ◽  
Vascular Leakage
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