Bladder Cancer Extracellular Vesicles Drive Tumorigenesis by Inducing Endoplasmic Reticulum Stress

2018 ◽  
Author(s):  
Chia-Hao Wu ◽  
Christopher R. Silvers ◽  
Edward M. Messing ◽  
Yi-Fen Lee
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Extracellular Vesicles

Panobinostat and ixazomib inhibit bladder cancer growth synergistically by increasing histone acetylation and inducing endoplasmic reticulum stress

2017 ◽  
Vol 16 (3) ◽  
pp. e1468-e1469
Author(s):  
A. Sato ◽  
M. Isono ◽  
T. Asano ◽  
K. Okubo ◽  
T. Asano
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Histone Acetylation ◽  
Cancer Growth

MP39-01 CALCIUM MEDIATED AUTOPHAGY INDUCTION PRESERVE CELL SURVIVAL DURING ENDOPLASMIC RETICULUM STRESS IN BLADDER CANCER

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Rani Ojha ◽  
Shrawan Singh ◽  
Arup Mandal ◽  
Shalmoli Bhattacharyya ◽  
Vivekanand Jha
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Survival ◽  
Autophagy Induction

Ritonavir and oprozomib cause bladder cancer apoptosis synergistically by inducing endoplasmic reticulum stress

2018 ◽  
Vol 17 (2) ◽  
pp. e657-e658
Author(s):  
A. Sato ◽  
T. Asano ◽  
K. Okubo ◽  
M. Isono ◽  
T. Asano
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

scholarly journals Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 2881 ◽  
Author(s):  
Yih-Gang Goan ◽  
Wen-Tung Wu ◽  
Chih-I Liu ◽  
Choo-Aun Neoh ◽  
Yu-Jen Wu
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Induced Apoptosis ◽  
Human Bladder Cancer Cells

Nobiletin (NOB) is a polymethoxylated flavonoid isolated from citrus fruit peel that has been shown to possess anti-tumor, antithrombotic, antifungal, anti-inflammatory and anti-atherosclerotic activities. The main purpose of this study was to explore the potential of using NOB to induce apoptosis in human bladder cancer cells and study the underlying mechanism. Using an MTT assay, agarose gel electrophoresis, a wound-healing assay, flow cytometry, and western blot analysis, this study investigated the signaling pathways involved in NOB-induced apoptosis in BFTC human bladder cancer cells. Our results showed that NOB at concentrations of 60, 80, and 100 μM inhibited cell growth by 42%, 62%, and 80%, respectively. Cells treated with 60 μM NOB demonstrated increased DNA fragmentation, and flow cytometry analysis confirmed that the treatment caused late apoptotic cell death. Western blot analysis showed that mitochondrial dysfunction occurred in NOB-treated BFTC cells, leading to cytochrome C release into cytosol, activation of pro-apoptotic proteins (caspase-3, caspase-9, Bad, and Bax), and inhibition of anti-apoptotic proteins (Mcl-1, Bcl-xl, and Bcl-2). NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2α/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway. Our results suggested that the cytotoxic and apoptotic effects of NOB on bladder cancer cells are associated with endoplasmic reticulum stress and mitochondrial dysfunction.

759 Ritonavir synergizes with carfilzomib to cause endoplasmic reticulum stress and autophagy in bladder cancer cells

2015 ◽  
Vol 14 (2) ◽  
pp. e759-e759a
Author(s):  
A. Sato ◽  
M. Isono ◽  
T. Asano ◽  
K. Okubo ◽  
K. Ito ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Bladder Cancer Cells

scholarly journals MP51-08 PANOBINOSTAT AND RITONAVIR CAUSE BLADDER CANCER APOPTOSIS BY INDUCING ENDOPLASMIC RETICULUM STRESS AND HISTONE ACETYLATION SYNERGISTICALLY

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Akinori Sato* ◽  
Takako Asano ◽  
Makoto Isono ◽  
Kazuki Okubo
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Histone Acetylation
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