Barriers Associated with Presentation Delay among Breast Cancer Patients at Hawassa University Comprehensive and Specialized Hospital, Southern Ethiopia

Abstract Background Breast cancer is the second most prevalent malignancy in Ethiopia and severely affects patients’ health-related quality of life (HRQOL). We aimed to assess HRQoL, factors influencing HRQoL, and utilities among breast cancer patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods A hospital-based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital from December 2017 to February, 2018. A total of 404 breast cancer patients were interviewed using the validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), EORTC QLQ-BR23, and Euro Quality of Life Group’s 5-Domain Questionnaires 5 Levels (EQ-5D-5 L) instruments. Mean scores and mean differences of EORTC- QLQ-C30 and EORTC- QLQ-BR23 were calculated. One-way ANOVA test was employed to determine the significance of mean differences among dependent and independent variables while stepwise multivariate logistic regression was used to identify factors associated with the global quality of life (GQOL). Coefficients and level specific utility values obtained from a hybrid regression model for the Ethiopian population were used to compute utility values of each health state. Data was analyzed using SPSS version 23. Results The mean age of patients was 43.94 ± 11.72 years. The mean score for GQoL and visual analog scale was 59.32 ± 22.94 and 69.94 ± 20.36, respectively while the mean utility score was 0.8 ± 0.25. Predictors of GQoL were stage of cancer (AOR = 7.94; 95% CI: 1.83–34.54), cognitive functioning (AOR = 2.38; 95% CI: 1.32–4.31), pain (AOR = 7.99; 95% CI: 4.62–13.83), financial difficulties (AOR = 2.60; 95% CI: 1.56–4.35), and future perspective (AOR = 2.08; 95% CI: 1.24–3.49). Conclusions The overall GQoL of breast cancer patients was moderate. Targeted approaches to improve patients’ HRQoL should consider stage of cancer, cognitive functioning, pain, financial status and worries about the patient’s future health. This study also provides estimates of EQ-5D utility scores that can be used in economic evaluations.

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Social support and quality of life among female breast cancer patients at Tikur Anbessa Specialized Hospital, Ethiopia 2019:Cross-sectional study

10.21203/rs.3.rs-33300/v1 ◽

2020 ◽

Author(s):

Rahel Aberaraw ◽

Jemal Hussien ◽

Abdisa Boka ◽

Roza Teshome ◽

Addisu Yeshambel

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Social Support ◽

Cancer Patients ◽

Female Breast Cancer ◽

P Value ◽

Breast Cancer Patients ◽

Female Breast ◽

Specialized Hospital

Abstract Background Breast cancer is a major life-threatening public health problem worlwide. It is the most common form of cancer among women in many developing countries including Ethiopia. Social support could change the course of cancer and can influence the quality of life among breast cancer patients. Therefore, purpose of this study was to assess social support and quality of life among female breast cancer patients attending in Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia 2019.Methods A Hospital-based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital, Ethiopia from March to April 2019. A total of 214 female breast cancer patients were included and a systematic sampling method was used. A structured and pre-tested questionnaire was used. Data entry was done using epi data manager version 4.2. Data analysis was done using Statistical Package for Social Sciences version 25. Binary and multiple logistic regression was used to show the association of social support and quality of life. Variables significantly associated were declared at P-value <0.05 and 95%CI was used.Result A total of 214 women with breast cancer were recruited. Of the total participants, 124(58%) had good social support. It was found that participants who were college graduated (AOR=3, 95%CI: 1.5, 5.9 COR=3.2) and who had high monthly income(AOR=2.3, 95% CI: 1.2,8.5, COR= 5.39) were more likely to have good social support. It was also found that participants who were illiterate (AOR=3, 95%CI: 1.3,6.9, COR=4.8, p-value=0.008), who had systematic therapy side effects(AOR=3.8, 95%CI: 1.1,13, COR=4, p-value=0.035)and participants who had problem of appetite loss(AOR=3.5, 95%CI: 1.02,12COR=4, p-value= 0.047) were more likely to have affected QoL. Conclusion In this study finding, social support and, quality of life in breast cancer patients was low. Healthcare providers should enhance social support which may help to improve the quality of life of women with breast cancer.

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Social networks and quality of life among female breast cancer patients at Tikur Anbessa Specialzed Hospital, Addis Ababa, Ethiopia 2019

10.21203/rs.2.12540/v1 ◽

2019 ◽

Author(s):

Rahle Aberaraw ◽

Addisu Yeshambel ◽

Abdisa Boka ◽

Roza Teshome

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Social Networks ◽

Cancer Patients ◽

Addis Ababa ◽

Female Breast Cancer ◽

Breast Cancer Patients ◽

Female Breast ◽

Specialized Hospital

Abstract Background Breast cancer is a major life-threatening public health problem in the world. It is the most common form of cancer among women in many developing countries including Ethiopia. Social networks could change the course of cancer and can influence the quality of life among breast cancer patients. Therefore, the purpose of this study was to assess social networks and quality of life among female breast cancer patients attending in Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia 2019. Methods An institutional based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia from March to April 2019. A total of 214 female breast cancer patients were included and systematic sampling method was used. A structured and pre-tested questionnaire was used. Data entry was done using epi data-manager version 4.2. Data analysis was done using Statistical Package for the Social Sciences version 25. Binary and multiple logistic regression was used to show the association of social networks and quality of life. The strength of association was declared P-value <0.05 and 95%CI was used. Result A total of 214 women with breast cancer were recruited. The mean age was 41.85. Among total participants, 13(6%), 65(30%) and 136(64%) had limited, medium and diverse social networks respectively. Whereas, 198(92.52%) of them had affected quality of life. Participants who were illiterate were more likely to have affected quality of life by 3 times than who were more educated (AOR=3, 95%CI: 1.3,6.9, COR=4.8) and who had systematic therapy side effects were more likely to have affected QoL by 3.8 times than who had no systemic therapy side effect (AOR=3.8, 95%CI: 1.1,13, COR=4). Conclusion and recommendation In this study finding quality of life in breast cancer was low. Healthcare providers especially working at oncology department need to focus on addressing side effects of therapy and social networks which may help to improve quality of life of women with breast cancer.

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Cognitive functioning and its associated factors among breast cancer patients on chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa Ethiopia: an institution-based comparative cross-sectional study

BMC Cancer ◽

10.1186/s12885-021-08799-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Edgeit Abebe ◽

Tesfaye Tollesa ◽

Mathewos Assefa ◽

Zelalem Tilahun ◽

Yohannes Dinku ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Functioning ◽

Cancer Patients ◽

Addis Ababa ◽

Cross Sectional Study ◽

Breast Cancer Patients ◽

Sectional Study ◽

Cross Sectional ◽

Specialized Hospital ◽

Tikur Anbessa Specialized Hospital

Abstract Background Breast cancer is the second leading cause of cancer in the world. It is the commonest type of cancer in Ethiopia. Cognitive problems are common among breast cancer patients. The study aimed to assess cognitive functioning and its associated factors among breast cancer patients at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia 2020. Methods Institution-based comparative cross-sectional study was conducted. Study subjects were 117 breast cancer patients on chemotherapy and 117 women without breast cancer who volunteered for the study. Data was collected from May–June 2020. The Mini-mental status exam (MMSE) was used to assess cognitive functioning. Data were entered into Epi Data version 4.6.0.2 and analyzed using STATA version 14 software. Univariable and multivariable linear regression model was fitted to identify factors associated with cognitive functioning. A two-tailed p-value less than 0.05 was used to declare statistical significance. Results Among the total breast cancer patients 41.9% were diagnosed with earlier sage of the diseases (stage I and II), while the rest 58.1% were diagnosed with stage III and stage IV breast cancer. A significant difference in the MMSE score was observed among breast cancer patients and controls (19.76 ± 5.29, 25.18 ± 4.68 p < 0.0001) respectively. In multivariable linear regression analysis being non-breast cancer (Adjusted beta coefficient (Adj.β.coff). = 3.34, 95% CI (1.92–4.76) p < 0.001), hemoglobin gm/dl (Adj.β.coff =0.34, 95% CI (0.04–0.63) p = 0.02), and primary education (Adj.β.coff =2.98 95%CI (1.16–4.96) p = 0.001) secondary level and more education (Adj.β.coff = 5.47, 95%CI (3.51–7.28) p < 0.001) were significantly associated with MMSE cognitive score. Conclusion Breast cancer patients had lower mean MMSE scores when compared to non-breast cancer women. Higher hemoglobin level and higher level of education increase the MMSE cognitive score. Clinicians should incorporate routine screening of cognitive functioning for breast cancer patients and further study is required to evaluate cognitive impairment among breast cancer patients in Ethiopia.

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Drug-related problems and its associated factors among breast cancer patients at the University of Gondar Comprehensive Specialized Hospital, Ethiopia: A hospital-based retrospective cross-sectional study

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220914710 ◽

2020 ◽

pp. 107815522091471

Author(s):

Amsalu Degu ◽

Kassu Kebede

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Associated Factors ◽

Cross Sectional Study ◽

Drug Related Problems ◽

Breast Cancer Patients ◽

Sectional Study ◽

Cross Sectional ◽

Specialized Hospital ◽

The University

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Survival analysis of Time to Death of Breast Cancer Patients: in case of Ayder Comprehensive Specialized Hospital Tigray, Ethiopia.

Cogent Medicine ◽

10.1080/2331205x.2021.1908648 ◽

2021 ◽

Vol 8 (1) ◽

pp. 1908648

Author(s):

Bsrat Tesfay ◽

Tewodros Getinet ◽

Endeshaw Assefa Derso

Keyword(s):

Breast Cancer ◽

Survival Analysis ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Time To Death ◽

Specialized Hospital

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Social networks and quality of life among female breast cancer patients at Tikur Anbessa Specialzed Hospital, Addis Ababa, Ethiopia 2019

10.21203/rs.2.12540/v4 ◽

2020 ◽

Author(s):

Rahle Aberaraw ◽

Abdisa Boka ◽

Roza Teshome ◽

Addisu Yeshambel

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Social Networks ◽

Cancer Patients ◽

Addis Ababa ◽

Female Breast Cancer ◽

Breast Cancer Patients ◽

Female Breast ◽

Specialized Hospital

Abstract Background: Breast cancer is a major life-threatening global public health problem. It is the most common form of cancer in females in many developing countries including Ethiopia. Social networks could change the course of cancer and can influence the quality of life among breast cancer patients. Therefore, the purpose of this study was to assess social networks and quality of life among female breast cancer patients attending in Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia 2019. Methods: An institutional-based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia from March 1 to April 30/2019. A total of 214 female breast cancer patients were included Binary and multiple logistic regression was used to show the association of social networks and quality of life. Result: A total of 214 females with breast cancer were recruited with a mean age of 41.85. Participants who had children (AOR=5, 95%CL: 1.3,21 COR=6), and other relatives (AOR=6, 95%CI: 1.2,30, COR=7), were more likely to have good social networks. Participants who were not married (AOR=0.02, 95%CI: 0.03, 0.28), had no parents living (AOR=0.1, 95%CI: 0.02, 0.4), no close friends (AOR=0.06, 95%CI: 0.01, 0.4), and no neighbors (AOR=0.09, 95%CI: 0.03, 0.5) had poor social networks. Conclusion: The quality of life was relatively low and social networks were found to be poor in women with breast cancer. Health-care providers in oncology departments need to focus on addressing the side effects of therapy and social networks which may help to improve the quality of life of females with breast cancer.

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Survival status and predictors of mortality among Breast Cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital, Addis Ababa, Ethiopia, 2018

10.1101/636431 ◽

2019 ◽

Cited By ~ 1

Author(s):

Habtamu Abera Areri ◽

Wondimeneh Shibabaw ◽

Tefera Mulugeta ◽

Yared Asmare ◽

Tadesse Yirga

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Clinical Stage ◽

Lymph Node Status ◽

Breast Cancer Patients ◽

Adjuvant Hormone Therapy ◽

Predictors Of Mortality ◽

Survival Status ◽

Specialized Hospital ◽

Oncology Unit

AbstractIntroductionBreast cancer is a foremost cause of death worldwide, ranks fifth among causes of death from all types of cancers; this is the most common cause of cancer death in women among both developing and developed countries. Breast cancer ranks first among most frequent cancers in women of Ethiopia. In spite of the high incidence, mortality rate, and survival status among breast cancer patients was not determined in Ethiopia.ObjectiveThe main aim of the study is to assess the survival status and predictor the mortality among Breast Cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital in 2018.MethodsAn institution based retrospective follow up study was conducted in Adult Oncology Unit at Black Lion Specialized Hospital. All cases of breast cancer registered from 1st January 2012 to 31th December,2014 were followed for the six-year survival (until 31th December, 2017). Kaplan-Meier survival curve together with log rank test was deployed to test for variations in the survival among predictor variables. Cox regression was used at 5% level of significance to determine the net effect of each independent variable on time to death of breast cancer clients.ResultsThe results indicate that the incidence rate of mortality was 9.8 per 100 person/ years (95% CI: 8.49-11.47).The overall median survival time was 56.5(95% CI (53.46 - 60.83)) months. The overall estimated survival rate was recorded 27% (95% CI, 17.09 to 36.67 %) at 72 months of follow up, whereas at odd years (1, 3, and 5 years) were, 97.2%, 80.8%, and 46.2% respectively. Predictors of mortality were assessed at clinical stage (III&IV),(AHR =1.86), poorly differentiated histology (AHR: 3.1) & positive lymph node status (AHR:3.13),Whereas adjuvant hormone therapy (AHR: 0.67) and chemotherapy (AHR:0.72) were protective.ConclusionThe overall probability of survival in Ethiopia was inferior when compared with other high and middle-income countries. Predictors of mortality were at advanced clinical stage, poorly differentiated histology grade, surgical margin involvement and positive lymph node status. In contrary, adjuvant hormone therapy, modified radical mastectomy and chemotherapy were protective factors. Hence, special emphasis could be given to early screening, stage diagnosis and initiation of treatment.

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