Drug-Induced Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey

2019 ◽  
Author(s):  
Chen Liu ◽  
Suying Yan ◽  
Jinwei Wang ◽  
Xiujuan Fu ◽  
Hongtao Song ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Cross Sectional Survey ◽  
Drug Induced ◽  
Cross Sectional

scholarly journals Drug-Induced Hospital-Acquired Acute Kidney Injury in China: A Multicenter Cross-Sectional Survey

2020 ◽  
pp. 1-13
Author(s):  
Chen Liu ◽  
Suying Yan ◽  
Yuqin Wang ◽  
Jinwei Wang ◽  
Xiujuan Fu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Cross Sectional Survey ◽  
Drug Induced ◽  
Cross Sectional ◽  
Hospital Acquired

scholarly journals Knowledge of acute kidney injury among Pakistani nurses: A cross-sectional survey

2021 ◽  
Vol 32 (2) ◽  
pp. 497
Author(s):  
Muhammad Salman ◽  
Zia Ul Mustafa ◽  
Noman Asif ◽  
Adejumo Oluseyi ◽  
Ayesha Saed ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Cross Sectional Survey ◽  
Cross Sectional

scholarly journals Correlation of serum magnesium levels with renal parameters in patients with acute kidney injury

2020 ◽  
Vol 8 (10) ◽  
pp. 3698
Author(s):  
Raveendra K. R. ◽  
Avinash H. R. ◽  
Nitish Ashok Gurav
Keyword(s):  
Diabetes Mellitus ◽  
Acute Kidney Injury ◽  
Obstructive Uropathy ◽  
Serum Magnesium ◽  
Kidney Injury ◽  
Drug Induced ◽  
Cross Sectional ◽  
Electrolyte Disturbance ◽  
Electrolyte Disturbances ◽  
Patients With Diabetes

Background: Acute kidney injury is a common problem with various causes and consequences like electrolyte disturbances in the form of hypocalcaemia, hypokalemia, hyperkalemia depending on the phase. Hypomagnesaemia is one of the most common electrolyte disturbance found in hospitalized patients especially in the critically ill patients. Prevalence of hypomagnesemia varies from 11 to 65% in different studies. Hence, we decided to conduct a study to evaluate correlation of serum magnesium levels in AKI.Methods: A cross-sectional, hospital based time bound study was conducted between November 2016 and August 2018 with a sample of 100 patients aged 18-65 years and who had AKI were included and patients with diabetes mellitus, multi-organ dysfunction, obstructive uropathy and drug induced AKI were excluded from study. The decrease in magnesium <1.7 mg/L was defined as hypomagnesaemia. AKI was defined as per AKIN criteria. Day 1, day 3 and day 6 magnesium levels were measured.Results: Prevalence of hypomagnesaemia was 53%, 30% and 36% on day 1, day 3 and day 6 respectively. It was observed that there was a positive correlation between serum magnesium, and serum creatinine. Normomagnsemia and hypermagnesemia on day 1, 3 and 6 were significantly associated with recovery of AKI (p<0.001).Conclusions: The prevalence of hypomagnesemia was significantly higher in AKI patients and normal magnesium and hypermagnesium on day 1, 3 and day 6 was associated with recovery than non-recovery. Hypomagnesemia was associated more with non-recovery then recovery.

scholarly journals Cross-sectional survey on adult acute kidney injury in Chinese ICU: the study protocol (CARE-AKI)

BMJ Open ◽  
2018 ◽  
Vol 8 (6) ◽  
pp. e020766
Author(s):  
Zhenyu Yang ◽  
Cong Wang ◽  
Hongliang Wang ◽  
Sicong Wang ◽  
Ruijin Liu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Study Protocol ◽  
Kidney Injury ◽  
Cross Sectional Survey ◽  
Cross Sectional

Acute kidney injury in China: a cross-sectional survey

The Lancet ◽  
2015 ◽  
Vol 386 (10002) ◽  
pp. 1465-1471 ◽  
Author(s):  
Li Yang ◽  
Guolan Xing ◽  
Li Wang ◽  
Yonggui Wu ◽  
Suhua Li ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Cross Sectional Survey ◽  
Cross Sectional

Serial Quantification of Urinary Protein Biomarkers to Predict Drug-induced Acute Kidney Injury

2019 ◽  
Vol 20 (8) ◽  
pp. 656-664 ◽  
Author(s):  
Yi Da ◽  
K. Akalya ◽  
Tanusya Murali ◽  
Anantharaman Vathsala ◽  
Chuen-Seng Tan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cystatin C ◽  
Calcineurin Inhibitors ◽  
Kidney Injury ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Protein Biomarkers ◽  
Drug Induced ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Background: : Drug-induced Acute Kidney Injury (AKI) develops in 10-15% of patients who receive nephrotoxic medications. Urinary biomarkers of renal tubular dysfunction may detect nephrotoxicity early and predict AKI. Methods:: We prospectively studied patients who received aminoglycosides, vancomycin, amphotericin, or calcineurin inhibitors, and collected their serial urine while on therapy. Patients who developed drug-induced AKI (fulfilling KDIGO criteria) were matched with non-AKI controls in a 1:2 ratio. Their urine samples were batch-analyzed at time-intervals leading up to AKI onset; the latter benchmarked against the final day of nephrotoxic therapy in non- AKI controls. Biomarkers examined include clusterin, beta-2-microglobulin, KIM1, MCP1, cystatin-C, trefoil-factor- 3, NGAL, interleukin-18, GST-Pi, calbindin, and osteopontin; biomarkers were normalized with corresponding urine creatinine. Results:: Nine of 84 (11%) patients developed drug-induced AKI. Biomarkers from 7 AKI cases with pre-AKI samples were compared with those from 14 non-AKI controls. Corresponding mean ages were 55(±17) and 52(±16) years; baseline eGFR were 99(±21) and 101(±24) mL/min/1.73m2 (all p=NS). Most biomarker levels peaked before the onset of AKI. Median levels of 5 biomarkers were significantly higher in AKI cases than controls at 1-3 days before AKI onset (all µg/mmol): clusterin [58(8-411) versus 7(3-17)], beta-2-microglobulin [1632(913-3823) versus 253(61-791)], KIM1 [0.16(0.13-0.76) versus 0.07(0.05-0.15)], MCP1 [0.40(0.16-1.90) versus 0.07(0.04-0.17)], and cystatin-C [33(27-2990) versus 11(7-19)], all p<0.05; their AUROC for AKI prediction were >0.80 (confidence intervals >0.50), with average accuracy highest for clusterin (86%), followed by beta-2-microglobulin, cystatin-C, MCP1, and KIM1 (57%) after cross-validation. Conclusion: : Serial surveillance of these biomarkers could improve the lead time for nephrotoxicity detection by days.

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