Higher Ultraviolet Radiation During Early Life Reduces Risk of Childhood Type 1 Diabetes Among Boys

Background: Iron overload has been associated with diabetes. Studies on iron exposure during pregnancy and in early life and risk of childhood type 1 diabetes (T1D) are sparse. We investigated whether iron supplementation during pregnancy and early in life were associated with risk of childhood T1D. Methods: In a case-cohort design, we identified up to 257 children with T1D (prevalence 0.37%) from the Danish National Birth Cohort through linkage with the Danish Childhood Diabetes Register. The primary exposure was maternal pure iron supplementation (yes/no) during pregnancy as reported in interview two at 30 weeks of gestation (n = 68,497 with iron supplement data). We estimated hazard ratios (HRs) using weighted Cox regression adjusting for multiple confounders. We also examined if offspring supplementation during the first 18 months of life was associated with later risk of T1D. Results: Maternal iron supplementation was not associated with later risk of T1D in the offspring HR 1.05 (95% CI: 0.76–1.45). Offspring intake of iron droplets during the first 18 months of life was inversely associated with risk of T1D HR 0.74 (95% CI: 0.55–1.00) (ptrend = 0.03). Conclusions: Our large-scale prospective study demonstrated no harmful effects of iron supplementation during pregnancy and in early life in regard to later risk of childhood T1D in the offspring.

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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

BMC Public Health ◽

10.1186/s12889-016-3690-9 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 6

Author(s):

F. Balazard ◽

◽

S. Le Fur ◽

S. Valtat ◽

A. J. Valleron ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Early Life ◽

Case Control Study ◽

Case Control ◽

Childhood Type 1 Diabetes ◽

Early Life Exposures ◽

Childhood Type ◽

Control Study

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Abstract #288 Dyslipidemia in Childhood Type 1 Diabetes in India: Prevalence Correlates and Management Challenges in a Resource Limited Setting

Endocrine Practice ◽

10.1016/s1530-891x(20)46632-7 ◽

2019 ◽

Vol 25 ◽

pp. 117

Author(s):

S Chandraprabha ◽

T Jayalakshmi ◽

Reshma Vijay ◽

Kavitha Muniraj ◽

Muralidhara Krishna ◽

...

Keyword(s):

Type 1 Diabetes ◽

Resource Limited Setting ◽

Resource Limited ◽

Childhood Type 1 Diabetes ◽

Childhood Type ◽

Limited Setting

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Clinical Pattern of Childhood Type 1 Diabetes Mellitus in Karbala, Iraq

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp1.201 ◽

2020 ◽

Vol 12 (sp1) ◽

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Clinical Pattern ◽

Childhood Type 1 Diabetes ◽

Childhood Type

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Type 1 Diabetes-related Autoantibodies in Different Forms of Diabetes

Current Diabetes Reviews ◽

10.2174/1573399814666180730105351 ◽

2019 ◽

Vol 15 (3) ◽

pp. 199-204 ◽

Cited By ~ 7

Author(s):

Elin Pettersen Sørgjerd

Keyword(s):

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Autoimmune Diabetes ◽

Acid Decarboxylase ◽

Adult Onset ◽

Latent Autoimmune Diabetes ◽

Childhood Type 1 Diabetes ◽

Childhood Type

Autoantibodies against Glutamic Acid Decarboxylase (GADA), insulinoma antigen-2 (IA- 2A), insulin (IAA) and the most recently Zinc Transporter 8 (ZnT8A) are one of the most reliable biomarkers for autoimmune diabetes in both children and adults. They are today the only biomarkers that can distinguish Latent Autoimmune Diabetes in Adults (LADA) from phenotypically type 2 diabetes. As the frequency of autoantibodies at diagnosis in childhood type 1 diabetes depends on age, GADA is by far the most common in adult onset autoimmune diabetes, especially LADA. Being multiple autoantibody positive have also shown to be more common in childhood diabetes compared to adult onset diabetes, and multiple autoantibody positivity have a high predictive value of childhood type 1 diabetes. Autoantibodies have shown inconsistent results to predict diabetes in adults. Levels of autoantibodies are reported to cause heterogeneity in LADA. Reports indicate that individuals with high levels of autoantibodies have a more type 1 diabetes like phenotype and individuals with low levels of autoantibody positivity have a more type 2 diabetes like phenotype. It is also well known that autoantibody levels can fluctuate and transient autoantibody positivity in adult onset autoimmune diabetes have been reported to affect the phenotype.

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