Molecular Basis of the Anti-Diabetic Properties of Camel Milk Through Profiling of Its Bioactive Peptides on DPP-IV and Insulin Receptor Activity

2020 ◽  
Author(s):  
Arshida Ashraf ◽  
Priti Mudgil ◽  
Abdulrasheed Palakkott ◽  
Rabah Iratni ◽  
Chee-Yuen Gan ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Molecular Basis ◽  
Bioactive Peptides ◽  
Receptor Activity ◽  
Camel Milk ◽  
Dpp Iv

scholarly journals Molecular basis of the anti-diabetic properties of camel milk through profiling of its bioactive peptides on dipeptidyl peptidase IV (DPP-IV) and insulin receptor activity

2021 ◽  
Vol 104 (1) ◽  
pp. 61-77
Author(s):  
Arshida Ashraf ◽  
Priti Mudgil ◽  
Abdulrasheed Palakkott ◽  
Rabah Iratni ◽  
Chee-Yuen Gan ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Molecular Basis ◽  
Bioactive Peptides ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Receptor Activity ◽  
Camel Milk ◽  
Dpp Iv

scholarly journals Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update

2021 ◽  
Vol 22 (17) ◽  
pp. 9508
Author(s):  
Nhung Thi Phuong Nong ◽  
Jue-Liang Hsu
Keyword(s):  
Bioactive Peptides ◽  
Protein Hydrolysate ◽  
Tyrosine Phosphatase ◽  
Food Protein ◽  
Dpp Iv ◽  
Glucosidase Inhibitors ◽  
Commercial Applications ◽  
Ptp 1B

Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges associated with a complex complication of health crises in the modern lifestyle. Inhibition or reduction of the dipeptidyl peptidase IV (DPP-IV), alpha-glucosidase, and protein-tyrosine phosphatase 1B (PTP-1B) enzyme activities or expressions are notably considered as the promising therapeutic strategies for the management of type 2 diabetes (T2D). Various food protein-derived antidiabetic bioactive peptides have been isolated and verified. This review provides an overview of the DPP-IV, PTP-1B, and α-glucosidase inhibitors, and updates on the methods for the discovery of DPP-IV inhibitory peptides released from food-protein hydrolysate. The finding of novel bioactive peptides involves studies about the strategy of separation fractionation, the identification of peptide sequences, and the evaluation of peptide characteristics in vitro, in silico, in situ, and in vivo. The potential of bioactive peptides suggests useful applications in the prevention and management of diabetes. Furthermore, evidence of clinical studies is necessary for the validation of these peptides’ efficiencies before commercial applications.

Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells

2006 ◽  
Vol 34 (5) ◽  
Author(s):  
Sharon S. Hori ◽  
Irwin J. Kurland ◽  
Joseph J. DiStefano
Keyword(s):  
Insulin Receptor ◽  
Receptor Activity ◽  
Endosomal Trafficking ◽  
Activity Models

scholarly journals Potential antioxidant bioactive peptides from camel milk proteins

2018 ◽  
Vol 4 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Hisham R. Ibrahim ◽  
Hiroki Isono ◽  
Takeshi Miyata
Keyword(s):  
Bioactive Peptides ◽  
Milk Proteins ◽  
Camel Milk ◽  
Camel Milk Proteins

scholarly journals Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B

2000 ◽  
Vol 6 (6) ◽  
pp. 1401-1412 ◽  
Author(s):  
Annette Salmeen ◽  
Jannik N Andersen ◽  
Michael P Myers ◽  
Nicholas K Tonks ◽  
David Barford
Keyword(s):  
Insulin Receptor ◽  
Protein Tyrosine Phosphatase ◽  
Molecular Basis ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Activation Segment

Recollection: Camel milk proteins, bioactive peptides and casein micelles

2017 ◽  
Vol 24 (2) ◽  
pp. 181
Author(s):  
Maryam Salami ◽  
Amir Niasari-Naslaji ◽  
A. Ali Moosavi-Movahedi
Keyword(s):  
Bioactive Peptides ◽  
Milk Proteins ◽  
Camel Milk ◽  
Casein Micelles ◽  
Camel Milk Proteins

A state-of-art review on camel milk proteins as an emerging source of bioactive peptides with diverse nutraceutical properties

2021 ◽  
pp. 131444
Author(s):  
Ali Ali Redha ◽  
Hamidreza Valizadenia ◽  
Shahida Anusha Siddiqui ◽  
Sajid Maqsood
Keyword(s):  
Bioactive Peptides ◽  
Milk Proteins ◽  
Camel Milk ◽  
Camel Milk Proteins ◽  
Nutraceutical Properties ◽  
State Of Art

scholarly journals In Silico Analysis of Bioactive Peptides Released from Giant Grouper (Epinephelus lanceolatus) Roe Proteins Identified by Proteomics Approach

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2910 ◽  
Author(s):  
Fenny Panjaitan ◽  
Honey Gomez ◽  
Yu-Wei Chang
Keyword(s):  
In Silico ◽  
Bioactive Peptides ◽  
In Silico Analysis ◽  
Epinephelus Coioides ◽  
Accession Number ◽  
Inhibitory Peptides ◽  
Dpp Iv ◽  
Ncbi Accession ◽  
Silico Analysis ◽  
Ncbi Accession Number

Major proteins contained in dried giant grouper roe (GR) such as vitellogenin (from Epinephelus coioides; NCBI accession number: AAW29031.1), apolipoprotein A-1 precursor (from Epinephelus coioides; NCBI accession number: ACI01807.1) and apolipoprotein E (from Epinephelus bruneus; NCBI accession number: AEB31283.1) were characterized through compiled proteomics techniques (SDS-PAGE, in-gel digestion, mass spectrometry and on-line Mascot database analysis). These proteins were subjected to in silico analysis using BLAST and BIOPEP-UWM database. Sequence similarity search by BLAST revealed that the aligned vitellogenin sequences from Epinephelus coioides and Epinephelus lanceolatus share 70% identity, which indicates that the sequence sample has significant similarity with proteins in sequence databases. Moreover, prediction of potential bioactivities through BIOPEP-UWM database resulted in high numbers of peptides predominantly with dipeptidyl peptidase-IV (DPP-IV) and angiotensin-I-converting enzyme (ACE-I) inhibitory activities. Pepsin (pH > 2) was predicted to be the most promising enzyme for the production of bioactive peptides from GR protein, which theoretically released 82 DPP-IV inhibitory peptides and 47 ACE-I inhibitory peptides. Overall, this work highlighted the potentiality of giant grouper roe as raw material for the generation of pharmaceutical products. Furthermore, the application of proteomics and in silico techniques provided rapid identification of proteins and useful prediction of its potential bioactivities.

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