Dual Targeting of the Epigenome Via Facilitates Chromatin Transcription Complex (FACT) and Histone Deacetylase is a Potent Treatment Strategy for DIPG

2020 ◽  
Author(s):  
Anahid Ehteda ◽  
Sandy Simon ◽  
Laura Franshaw ◽  
Federico M. Giorgi ◽  
Jie Liu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Treatment Strategy ◽  
Dual Targeting ◽  
Facilitates Chromatin Transcription

scholarly journals Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Cell Reports ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 108994
Author(s):  
Anahid Ehteda ◽  
Sandy Simon ◽  
Laura Franshaw ◽  
Federico M. Giorgi ◽  
Jie Liu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Treatment Strategy ◽  
Dual Targeting

Abstract 1884: Dual targeting of cell cycle checkpoint and histone deacetylase overcomes bortezomib resistance in multiple myeloma

2018 ◽  
Author(s):  
Takayuki Tabayashi ◽  
Yuka Tanaka ◽  
Yasuyuki Takahashi ◽  
Yuta Kimura ◽  
Tatsuki Tomikawa ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Multiple Myeloma ◽  
Histone Deacetylase ◽  
Cell Cycle Checkpoint ◽  
Dual Targeting ◽  
Cycle Checkpoint

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer

2015 ◽  
Vol 58 (11) ◽  
pp. 4550-4572 ◽  
Author(s):  
Chu Tang ◽  
Changhao Li ◽  
Silong Zhang ◽  
Zhiye Hu ◽  
Jun Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Histone Deacetylase ◽  
Hybrid Compound ◽  
Dual Targeting

scholarly journals Dual-targeting biomimetic delivery for anti-glioma activityviaremodeling the tumor microenvironment and directing macrophage-mediated immunotherapy

2018 ◽  
Vol 9 (10) ◽  
pp. 2674-2689 ◽  
Author(s):  
Pengfei Zhao ◽  
Yonghui Wang ◽  
Xuejia Kang ◽  
Aihua Wu ◽  
Weimin Yin ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Treatment Strategy ◽  
Dual Targeting

A dual-targeting biomimetic codelivery and treatment strategy was developed for anti-glioma activity.

scholarly journals Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors

2012 ◽  
Vol 55 (4) ◽  
pp. 1465-1477 ◽  
Author(s):  
William Guerrant ◽  
Vishal Patil ◽  
Joshua C. Canzoneri ◽  
Adegboyega K. Oyelere
Keyword(s):  
Histone Deacetylase ◽  
Topoisomerase Ii ◽  
Dual Targeting

scholarly journals Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer

EBioMedicine ◽  
2016 ◽  
Vol 10 ◽  
pp. 124-136 ◽  
Author(s):  
Tzu-Tang Wei ◽  
Yi-Ting Lin ◽  
Wen-Shu Chen ◽  
Ping Luo ◽  
Yu-Chin Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Histone Deacetylase ◽  
Coenzyme A ◽  
Dual Targeting ◽  
Coenzyme A Reductase

scholarly journals Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Blood ◽  
2014 ◽  
Vol 123 (9) ◽  
pp. 1341-1352 ◽  
Author(s):  
Michael Bots ◽  
Inge Verbrugge ◽  
Benjamin P. Martin ◽  
Jessica M. Salmon ◽  
Margherita Ghisi ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Histone Deacetylase ◽  
Treatment Strategy ◽  
Myeloid Leukemia ◽  
Histone Deacetylase Inhibitors ◽  
Differentiation Therapy ◽  
Rational Treatment ◽  
Key Points ◽  
Acute Myeloid

Key Points HDACi-mediated differentiation therapy is a potent and molecularly rational treatment strategy in t(8;21) AML.

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