scholarly journals Pea Protein Reduce Serum Cholesterol Levels in Hypercholesterolemia Hamsters by Modulating Compositions Of Gut Microbiota And Metabolites

2021 ◽  
Author(s):  
Li-Tao Tong ◽  
Tianzhen Xiao ◽  
Lili Wang ◽  
Cong Lu ◽  
Liya Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Serum Cholesterol ◽  
Pea Protein ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol

scholarly journals Pea Protein Reduce Serum Cholesterol Levels in Hypercholesterolemia Hamsters by Modulating Compositions of Gut Microbiota and Metabolites

2021 ◽  
Author(s):  
Li-Tao Tong ◽  
Tianzhen Xiao ◽  
Lili Wang ◽  
Cong Lu ◽  
Liya Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cholesterol Level ◽  
Serum Cholesterol ◽  
Serum Cholesterol Level ◽  
Cholesterol Metabolism ◽  
Cholesterol Concentration ◽  
Plant Proteins ◽  
Pea Protein ◽  
Cholesterol Levels ◽  
Meat Proteins

Abstract Background: Epidemiological and experimental studies have indicated that an increase of plant proteins in diets, as well as a substitution of red meat proteins or processed meat proteins with plant proteins, was closely associated with the reduction of cardio-cerebrovascular disease (CVD)-related mortality. One of the most important ways of plant proteins to reduce the incidence rate of CVD is to lowering cholesterol concentration in serum and liver. Mounting evidences have attributed this effect of plant proteins to their regulation of gut microbiota. However, it remains to be elucidated whether gut microbiota play decisive roles in modulating host cholesterol by dietary protein from diverse sources of plant or meat. This study attempted to clarify the relevant mechanisms by comparing the difference in cholesterol metabolism modulation between pea and pork proteins intake of hypercholesterolemia hamster, as well as its relationships with gut microbiome and metabolic pathway.Results: We have verified that there are significant differences in the regulations of serum and liver cholesterol levels among different proteins intake from plants (rice, oat, soybean, pea) or meat (chicken, pork, beef), and the corresponded differences in gut microbiota were also observed. The decisive roles of gut microbiota in regulating host cholesterol were illustrated by the findings that the differences in serum cholesterol level between pea protein and pork protein disappeared in the hamsters treated with antibiotics. The experimental results of cross-over intervention of pea and pork protein showed that the serum cholesterol level was reversed with dietary exchange. Most interestingly, the corresponded changes in abundance of dominant bacteria suggested that the “beneficial” microbe Muribaculaceae were responsible for the inhibitory effect of pea protein on serum cholesterol level, while the opposite effect of pork protein was due to the “harmful” microbe Erysipelotrichaceae. Moreover, dietary pea protein supplement altered cecal metabolites including changes in arginine/histidine pathway, primary bile acid biosynthesis, short chain fatty acids or other lipid-like molecules, which involved in cholesterol metabolism.Conclusion: Dietary pea protein exerted cholesterol-lowering effects through modulating the growth of selected gut microbiota in hamsters. The substitution of pork protein with pea protein could reshape the gut microbiota, affect the contents of metabolites in caecum, and thus regulate cholesterol metabolism. These findings suggest specific bacteria and metabolites can be potential therapeutic targets of hypercholesterolemia by plant protein intervention.

scholarly journals Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites

iScience ◽  
2021 ◽  
pp. 103435
Author(s):  
Li-Tao Tong ◽  
Tianzhen Xiao ◽  
Lili Wang ◽  
Cong Lu ◽  
Liya Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Serum Cholesterol ◽  
Plant Protein ◽  
Cholesterol Levels

scholarly journals Dietary fermented products using koji mold and sweet potato-shochu distillery by-product promotes hepatic and serum cholesterol levels and modulates gut microbiota in mice fed a high-cholesterol diet

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7671 ◽  
Author(s):  
Toshiki Kosakai ◽  
Hirotaka Kato ◽  
Cho Sho ◽  
Kuniaki Kawano ◽  
Ken-ichi Iwai ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Sweet Potato ◽  
Serum Cholesterol ◽  
Density Lipoprotein ◽  
Diet Group ◽  
High Cholesterol Diet ◽  
Tissue Samples ◽  
Cholesterol Levels ◽  
Koji Mold ◽  
Fermented Products

It has been reported that fermented products (FPs) prepared from sweet potato-shochu distillery by-product suppressed weight gain and decreased serum cholesterol levels in mice under normal dietary conditions. Furthermore, from the information gained from the above data regarding health benefits of the FPs, the aim of this study was evaluating the effects of dietary FPs on lipid accumulation and gut microbiota in mice with or without cholesterol-load in the diet. C57BL/6N mice were fed normal (CO) diet, CO with 10% FPs (CO + FPs) diet, cholesterol loaded (HC) diet, or HC with 10% FPs (HC + FPs) diet for 8 weeks. The mice were then euthanized, and blood samples, tissue samples, and feces were collected. The adipose tissue weight and liver triglyceride levels in the HC + FPs diet groups were significantly reduced compared to that in the HC diet groups. However, FPs significantly increased the serum non-high-density lipoprotein cholesterol (HDL-C) levels, the ratio of non-HDL-C to HDL-C and hepatic total cholesterol levels in mice fed cholesterol-loaded diet compared with that of the HC diet group. Since dietary FPs significantly decreased the protein expression levels of cholesterol 7 alpha-hydroxylase 1 in the HC + FPs diet groups, the cholesterol accumulation in FPs group may be explained by insufficient catabolism from cholesterol to bile acid. In addition, the dietary FPs tended to increase Clostridium cluster IV and XIVa, which are butyrate-producing bacteria. Related to the result, n-butyrate was significantly increased in the CO + FPs and the HC + FPs diet groups compared to their respective control groups. These findings suggested that dietary FPs modulated the lipid pool and gut microbiota.

Cholesterol Reduction among Volunteers in a Health Promotion Project

1988 ◽  
Vol 2 (4) ◽  
pp. 5-12 ◽  
Author(s):  
Steven P. Singleton ◽  
Anne Victoria Neale ◽  
Richard O. Scott ◽  
Joseph W. Hess
Keyword(s):  
Health Promotion ◽  
Serum Cholesterol ◽  
Intervention Strategy ◽  
Heart Association ◽  
High Serum ◽  
Dietary Guidelines ◽  
Health Promotion Program ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol

Behavioral contracting was used with moderate success as a primary intervention strategy in an urban clinic-based health promotion program designed to reduce serum cholesterol. Of the 223 adults screened, 144 had high serum cholesterol. One hundred and eighteen attended an interpretation/education session, and 51 participants agreed to sign a behavioral contract. Among those who signed contracts, adherence to American Heart Association dietary guidelines was significantly related to serum cholesterol changes. Eleven of the 46 adults who returned for the six-month clinical assessment reduced their cholesterol levels to recommended levels.

scholarly journals Analysis of Serum Cholesterol, Statins and Atherosclerotic Plaque in Ruptured and Unruptured Intracranial Aneurysm

2022 ◽  
Author(s):  
Leonardo Zumerkorn Pipek ◽  
Nícollas Nunes Rabelo ◽  
Henrique Zumerkorn Pipek ◽  
Joao Paulo Mota Telles ◽  
Natalia Camargo Barbat ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Atherosclerotic Plaque ◽  
Serum Cholesterol ◽  
Linear Regression Models ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol ◽  
Radiological Images ◽  
The Impact

Abstract Introduction Intracranial aneurysm (IA) is a major healthcare concern. The use of statin to reduce serum cholesterol has shown evidence to reduce cardiovascular risk in various diseases, but the impact on IA has not been described. This study aims to determine whether statin use, and serum cholesterol levels interfere with outcomes after IA event. Methods A cohort of patients with IA was analyzed. Patients social and demographics data were collected. Modified Rankin scale (mRS) score after 6 months of follow-up was the endpoint. The data regarding statins use, presence or not of atherosclerotic plaque in radiological images and serum cholesterol of 35 patients were included in our study. Linear regression models were used to determine the influence of those 6 variables in the clinical outcome. Results The prevalence of atherosclerotic plaque, high cholesterol and use of statins was 34.3%, 48.5%, and 14.2%, respectively. Statins and serum cholesterol did not impact the overall outcome, measured by mRS after 6 months (p > 0.05), but did show different tendencies when separated by IA rupture status. Serum cholesterol shows an important association with rupture of aneurysm (p = 0.0382). High cholesterol and use of statins show a tendency for worse outcome with ruptured aneurysm, and the opposite is true for unruptured aneurysm. The presence of atherosclerotic plaques was not related with worse outcomes. Conclusions Multiple and opposite mechanisms might be involved in the pathophysiology of IA. Ruptured aneurysms are associated with higher levels of serum cholesterol. Serum cholesterol and statins use were not correlated with worse outcomes, but further studies are important to clarify these relationships.

Enterostatin (VPDPR) and Its Peptide Fragment DPR Reduce Serum Cholesterol Levels after Oral Administration in Mice

2003 ◽  
Vol 67 (7) ◽  
pp. 1620-1622 ◽  
Author(s):  
Yasuyuki TAKENAKA ◽  
Futoshi NAKAMURA ◽  
Taichi YAMAMOTO ◽  
Masaaki YOSHIKAWA
Keyword(s):  
Oral Administration ◽  
Serum Cholesterol ◽  
Peptide Fragment ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol

scholarly journals Tea Catechins Reduce Serum Cholesterol Levels in Mild and Borderline Hypercholesterolemia Patients

2003 ◽  
Vol 33 (3) ◽  
pp. 101-111 ◽  
Author(s):  
Osami Kajimoto ◽  
Yoshitaka Kajimoto ◽  
Mitsuharu Yabune ◽  
Ayumu Nozawa ◽  
Kozo Nagata ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Tea Catechins ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol

Cost-Effectiveness of Populationwide Educational Approaches to Reduce Serum Cholesterol Levels

Circulation ◽  
1997 ◽  
Vol 95 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Anna N.A. Tosteson ◽  
Milton C. Weinstein ◽  
Maria G.M. Hunink ◽  
Murray A. Mittleman ◽  
Lawrence W. Williams ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Serum Cholesterol ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol
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