Acute Coronavirus Disease (COVID-19) in Vaccinated Frontline Healthcare Workers in India: An Observational Cohort Study

2021 ◽  
Author(s):  
Jinghao Nicholas Ngiam ◽  
Benjamin YQ Tan ◽  
Erum Khan ◽  
Nicholas WS Chew ◽  
Suryanarayana Sharma PMS ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Observational Cohort Study ◽  
Observational Cohort ◽  
Frontline Healthcare Workers

scholarly journals Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: an observational cohort study.

2021 ◽  
Author(s):  
Naomi F Walker ◽  
Rachel Louise Byrne ◽  
Ashleigh Howard ◽  
Elissavet Nikolaou ◽  
Madlen Farrar ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Asymptomatic Infection ◽  
Observational Cohort Study ◽  
Symptom Profiles ◽  
Symptom Screening ◽  
Observational Cohort ◽  
Uk National Health Service ◽  
The Uk ◽  
Frontline Healthcare Workers

Background The SARS-CoV-2 pandemic has caused an unprecedented strain on healthcare systems worldwide, including the UK National Health Service (NHS). During the first wave of SARS-CoV-2 transmission in UK, SARS-CoV-2 NHS diagnostic test availability was limited to self-isolating symptomatic staff. The burden of symptomatic and asymptomatic infection in healthcare workers (HCW) attending work was unknown. Methods We conducted an observational cohort study of SARS-CoV-2 infection in HCW working in an acute NHS Trust during the first wave of the COVID-19 pandemic, using serial self-collected saliva and nasopharyngeal (NP) samples. We also collected self-assessed symptom profiles and isolation behaviours. We retrospectively compared SARS-CoV-2 detection by RT-PCR from saliva (weekly) and NP swabs (twice weekly) from 85 individuals in this cohort and evaluated the association with symptoms. Findings Over a 12-week period from 30th March 2020, 40% (n=34/85, CI95% 31.3-51.8%) HCWs had evidence of SARS-CoV-2 infection by surveillance NP swab and/or saliva RT-qPCR. Agreement between paired saliva and NP swabs was poor (28.6%, CI95% 13.2-48.7%) with both methods detecting symptomatic and asymptomatic infections. Symptoms were reported by 47.1% (n=40) and self-isolation by 25.9% participants (n=22). Only 41.2% (n=14/34) participants with SARS-CoV-2 infection reported any symptoms within 14 days of the infection. Interpretation HCWs are a potential source of SARS-CoV-2 transmission in hospitals and symptom screening will identify the minority of infections in HCW. Saliva is an easily accessible fluid sample for screening for SARS-CoV-2 infection and in addition to NP swab, facilitated ascertainment of symptomatic and asymptomatic cases in this setting. Combined saliva and NP testing would improve detection of SARS-CoV-2 for surveillance. Better understanding of transmissibility from asymptomatic staff using transmission-based infection precautions, is required to inform policy.

scholarly journals Prevalence and Course of IgA and IgG Antibodies against SARS-CoV-2 in Healthcare Workers during the First Wave of the COVID-19 Outbreak in Germany: Interim Results from an Ongoing Observational Cohort Study

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 498
Author(s):  
Mark Reinwald ◽  
Peter Markus Deckert ◽  
Oliver Ritter ◽  
Henrike Andresen ◽  
Andreas G. Schreyer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Significant Proportion ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Observational Cohort Study ◽  
Igg Antibodies ◽  
University Hospitals ◽  
Observational Cohort

(1) Background: Healthcare workers (HCWs) are prone to intensified exposure to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the ongoing pandemic. We prospectively analyzed the prevalence of antibodies against SARS-CoV-2 in HCWs at baseline and follow up with regard to clinical signs and symptoms in two university hospitals in Brandenburg, Germany. (2) Methods: Screening for anti-SARS-CoV-2 IgA and IgG antibodies was offered to HCWs at baseline and follow up two months thereafter in two hospitals of Brandenburg Medical School during the first wave of the COVID-19 pandemic in Germany in an ongoing observational cohort study. Medical history and signs and symptoms were recorded by questionnaires and analyzed. (3) Results: Baseline seroprevalence of anti-SARS-CoV-2 IgA was 11.7% and increased to 15% at follow up, whereas IgG seropositivity was 2.1% at baseline and 2.2% at follow up. The rate of asymptomatic seropositive cases was 39.5%. Symptoms were not associated with general seropositivity for anti-SARS-CoV-2; however, class switch from IgA to IgG was associated with increased symptom burden. (4) Conclusions: The seroprevalence of antibodies against SARS-CoV-2 was low in HCWs but higher compared to population data and increased over time. Screening for antibodies detected a significant proportion of seropositive participants cases without symptoms.

scholarly journals COVID-19 hospital outbreaks: Protecting healthcare workers to protect frail patients. An Italian observational cohort study

2021 ◽  
Vol 102 ◽  
pp. 532-537
Author(s):  
Luigi Vimercati ◽  
Luigi De Maria ◽  
Marco Quarato ◽  
Antonio Caputi ◽  
Pasquale Stefanizzi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Observational Cohort Study ◽  
Frail Patients ◽  
Observational Cohort

scholarly journals Reactogenicity of homologous and heterologous prime-boost immunization with BNT162b2 and ChAdOx1-nCoV19: a prospective cohort study

2021 ◽  
Author(s):  
David Hillus ◽  
Pinkus Tober-Lau ◽  
Hana Hastor ◽  
Elisa T. Helbig ◽  
Lena J. Lippert ◽  
...  
Keyword(s):  
Cohort Study ◽  
Healthcare Workers ◽  
Age Groups ◽  
Booster Vaccination ◽  
Observational Cohort Study ◽  
Vaccination Regimen ◽  
Systemic Reactions ◽  
Boost Immunization ◽  
Observational Cohort ◽  
Local Reactions

Heterologous prime-boost vaccination is of increasing interest for COVID-19 vaccines. Evidence of rare thrombotic events associated with ChAdOx1-nCoV19 (Vaxzevria, ChAdOx) has lead several European countries to recommend a heterologous booster with mRNA vaccines for certain age groups (e.g. persons <60years in Germany), who have already received one dose of ChAdOx, although data on reactogenicity and safety of this vaccination regimen are still missing. Here we report reactogenicity data of homologous BNT162b2 (Comirnaty, BNT) or heterologous ChAdOx/BNT prime-boost immunisations in a prospective observational cohort study of 326 healthcare workers. Reactogenicity of heterologous ChAdOx/BNT booster vaccination was largely comparable to homologous BNT/BNT vaccination and overall well-tolerated. No major differences were observed in the frequency or severity of local reactions after either of the vaccinations. In contrast, notable differences between the regimens were observed for systemic reactions, which were most frequent after prime immunisation with ChAdOx (86%, 95CI: 79-91), and less frequent after homologous BNT/BNT (65%, 95CI: 56-72), or heterologous ChAdOx/BNT boosters (48%, 95CI: 36-59). This interim analysis supports the safety of currently recommended heterologous ChAdOx/BNT prime-boost immunisations with 12-week intervals.

Influence of vitamin D on outcomes following burn injury: An observational cohort study

2017 ◽  
Author(s):  
Khaled Al-Tarrah ◽  
Carl Jenkinson ◽  
Martin Hewison ◽  
Naiem Moiemen ◽  
Janet Lord
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Burn Injury ◽  
Observational Cohort Study ◽  
Observational Cohort
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