Reference Cut-Offs to Define Low Serum Zinc Concentrations in 1-19 Year Old Indian Children and Adolescents

ABSTRACT Background It is thought that there is a high risk of zinc deficiency in India, but there are no representative national estimates. Objectives We aimed to evaluate the national and state-level prevalence of low serum zinc concentrations (SZCs) in Indian children from the nationally representative Comprehensive National Nutrition Survey. Methods Prevalence of low SZC, adjusted for C-reactive protein, was estimated among preschool (1–4 y; n = 7874) and school-age children (5–9 y; n = 10,430) and adolescents (10–19 y; n = 10,140), using SZC cutoffs defined by the International Zinc Nutrition Consultative Group. Results Prevalence of low SZC was high among adolescents (31.1%; 95% CI: 29.8%, 32.4%), compared with school-age (15.8%; 95% CI: 15.3%, 16.3%) or preschool children (17.4%; 95% CI: 16.7%, 18.0%). However, stratification of prevalence by fasting status or using an alternative lower SZC cutoff independent of fasting status led to a reduction in prevalence by 3.7% or 7.8% in children <10 y, respectively. The prevalence of low SZC was higher among rural preschool children, those belonging to households with poor socioeconomic status, and those with severe stunting or underweight. Preschool children with diarrhea (22.6%; 95% CI: 20.8%, 24.4%), productive cough (22.7%; 95% CI: 18.5%, 27.5%), or malaria/dengue (38.5%; 95% CI: 29.4%, 48.2%) in the 2 wk preceding the survey had a higher prevalence of low SZC than those without morbidity (16.5%; 95% CI: 15.9%, 17.2%; 17.6%; 95% CI: 16.9%, 18.2%; and 17.5%; 95% CI: 16.8%, 18.1%, respectively). Conclusions The national prevalence of low SZC among preschool (17%) or school-age children (16%) was <20%, which is considered the cutoff indicating a problem of public health significance; but there were variations by state and socioeconomic status. In adolescents, however, the prevalence of low SZC was 31%, which warrants further investigation. The association of low SZC with diarrhea in preschool children necessitates better coverage of Zn administration in the management of diarrhea.

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Association between serum zinc concentrations and metabolic risk factors among Chinese children and adolescents

British Journal Of Nutrition ◽

10.1017/s0007114521000258 ◽

2021 ◽

pp. 1-31

Author(s):

Qianrang Zhu ◽

Yue Dai ◽

Jingxian Zhang ◽

Wei Xie ◽

Hui Zuo ◽

...

Keyword(s):

Risk Factors ◽

Children And Adolescents ◽

Density Lipoprotein ◽

Serum Zinc ◽

Negative Association ◽

Metabolic Risk Factors ◽

Chinese Children ◽

Metabolic Risk ◽

Zinc Concentrations ◽

Chinese Children And Adolescents

Abstract Purpose Zinc plays an important role in metabolic processes in human organisms and is indispensable in many enzymatic processes. To date, few studies have assessed the association between serum zinc and metabolic risk factors in children and adolescents. The aim of the present study was to examine whether serum zinc concentrations was associated with metabolic risk factors in Chinese children and adolescents. Methods This study was a cross-sectional analysis of data from the 2016-2017 China National Nutrition and Health Surveillance for Children and Nursing in Jiangsu Province. A total of 3241 participants aged 6 -17years were included. Metabolic risk factors included fasting glucose (FG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), systolic blood pressure and diastolic blood pressure. Data were analyzed using multivariable linear regression and generalized additive models, which were adjusted for age, gender, high sensitive C-reactive protein, estimated glomerular filtration rate, body mass index and region of residence, to assess the associations of serum zinc concentrations with metabolic risk factors. Results We observed a negative association between serum zinc concentrations and FG (coefficient = -0.532; 95% CI: -0.569, -0.495; p< 0.001). Moreover, TC (coefficient = 0.175 ; 95% CI 0.127, 0.222; p< 0.001), HDL-C (coefficient = 0.137 ; 95% CI 0.082, 0.193; p< 0.001) and LDL-C (coefficient = 0.195 ; 95% CI 0.128, 0.263; p< 0.001) were found to be positively associated with zinc levels. A generalized additive model showed that the negative association between serum zinc and FG was weak at lower serum zinc concentrations, and was stronger with the increase in serum zinc concentrations. Additionally, a U-shaped association between serum zinc and TG was observed. Conclusions Serum zinc concentrations were associated with FG, TC, TG, HDL-C and LDL-C levels in Chinese children and adolescents. Lower levels of serum zinc were more likely related to a poor metabolic status.

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Low serum zinc concentrations predict mortality in patients referred to coronary angiography

British Journal Of Nutrition ◽

10.1017/s0007114508084079 ◽

2008 ◽

Vol 101 (10) ◽

pp. 1534 ◽

Cited By ~ 16

Author(s):

Stefan Pilz ◽

Harald Dobnig ◽

Brigitte M. Winklhofer-Roob ◽

Wilfried Renner ◽

Ursula Seelhorst ◽

...

Keyword(s):

Coronary Angiography ◽

Serum Zinc ◽

Zinc Concentrations ◽

Low Serum

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Clinical Significance of Serum Zinc Levels in Cerebral Ischemia

Stroke Research and Treatment ◽

10.4061/2010/245715 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Archit Bhatt ◽

Muhammad U. Farooq ◽

Sailaja Enduri ◽

Clement Pillainayagam ◽

Bharath Naravetla ◽

...

Keyword(s):

Functional Status ◽

Serum Zinc ◽

Stroke Severity ◽

Stroke Outcome ◽

Cellular Functions ◽

Zinc Concentrations ◽

Poor Functional Status ◽

Zinc Levels ◽

Serum Zinc Levels ◽

Low Serum

Background. Zinc mediates several vital physiological, enzymatic and cellular functions. The association between serum zinc and stroke outcome has not been previously evaluated.Methods. This single center retrospective study was conducted on consecutive stroke () and TIA () patients. We sought to determine whether serum zinc concentrations in patients with acute ischemic strokes were associated with stroke severity and poor functional status at discharge, respectively.Results. Overall, out of the 224 patients analyzed (mean age 67 years), 35.7% patients had low zinc levels (65 mcg/dL). Patients with stroke () were more likely to have low zinc levels (, CI , ) compared to patients with TIA (). For patients with stroke (), multivariate analysis showed that low serum zinc levels (OR 2.82, CI , ) and strokes with admission severe strokes () (OR 2.68, CI , ) were independently associated with poor functional status () at discharge from the hospital.Conclusion. Low serum zinc concentrations are associated with more severe strokes on admission and poor functional status at discharge.

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