High-Field iMRI Guided Resection in Cerebral Glioma Surgery: A Prospective, Randomized, Parallel Controlled Trial

2021 ◽  
Author(s):  
Zeyang Li ◽  
Yanyan Song ◽  
N. U. Farrukh Hameed ◽  
Shiwen Yuan ◽  
Shuai Wu ◽  
...  
Keyword(s):  
High Field ◽  
Controlled Trial ◽  
Cerebral Glioma ◽  
Glioma Surgery

3.0-T Intraoperative Magnetic Resonance Imaging-Guided Resection in Cerebral Glioma Surgery: Interim Analysis of a Prospective, Randomized, Triple-Blind, Parallel-Controlled Trial

Neurosurgery ◽  
2014 ◽  
Vol 61 (CN_suppl_1) ◽  
pp. 145-154 ◽  
Author(s):  
Jin-Song Wu ◽  
Xiu Gong ◽  
Yan-Yan Song ◽  
Dong-Xiao Zhuang ◽  
Cheng-Jun Yao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Interim Analysis ◽  
Controlled Trial ◽  
Cerebral Glioma ◽  
Resonance Imaging ◽  
Glioma Surgery ◽  
Intraoperative Magnetic Resonance Imaging ◽  
3.0 T

Quantification of Glioma Removal by Intraoperative High-Field Magnetic Resonance Imaging: An Update

Neurosurgery ◽  
2011 ◽  
Vol 69 (4) ◽  
pp. 852-863 ◽  
Author(s):  
Daniela Kuhnt ◽  
Oliver Ganslandt ◽  
Sven-Martin Schlaffer ◽  
Michael Buchfelder ◽  
Christopher Nimsky
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Field ◽  
Tumor Volume ◽  
Tumor Resection ◽  
World Health ◽  
Incomplete Resection ◽  
Resonance Imaging ◽  
Glioma Surgery ◽  
Who Grade

Abstract BACKGROUND: The beneficial role of the extent of resection (EOR) in glioma surgery in correlation to increased survival remains controversial. However, common literature favors maximum EOR with preservation of neurological function, which is shown to be associated with a significantly improved outcome. OBJECTIVE: In order to obtain a maximum EOR, it was examined whether high-field intraoperative magnetic resonance imaging (iMRI) combined with multimodal navigation contributes to a significantly improved EOR in glioma surgery. METHODS: Two hundred ninety-three glioma patients underwent craniotomy and tumor resection with the aid of intraoperative 1.5 T MRI and integrated multimodal navigation. In cases of remnant tumor, an update of navigation was performed with intraoperative images. Tumor volume was quantified pre- and intraoperatively by segmentation of T2 abnormality in low-grade and contrast enhancement in high-grade gliomas. RESULTS: In 25.9% of all cases examined, additional tumor mass was removed as a result of iMRI. This led to complete tumor resection in 20 cases, increasing the rate of gross-total removal from 31.7% to 38.6%. In 56 patients, additional but incomplete resection was performed because of the close location to eloquent brain areas. Volumetric analysis showed a significantly (P < .01) reduced mean percentage of tumor volume following additional further resection after iMRI from 33.5% ± 25.1% to 14.7% ± 23.3% (World Health Organization [WHO] grade I, 32.8% ± 21.9% to 6.1% ± 18.8%; WHO grade II, 24.4% ± 25.1% to 10.8% ± 11.0%; WHO grade III, 35.1% ± 27.3% to 24.8% ± 26.3%; WHO grade IV, 34.2% ± 23.7% to 1.2% ± 16.2%). CONCLUSION: MRI in conjunction with multimodal navigation and an intraoperative updating procedure enlarges tumor-volume reduction in glioma surgery significantly without higher postoperative morbidity.

TM1-1 Seizure prophylaxis in gliomas (SPRING): a phase III randomised controlled trial comparing prophylactic levetiracetam versus no prophylactic anti-epileptic drug in glioma surgery

2019 ◽  
Vol 90 (3) ◽  
pp. e8.2-e8
Author(s):  
MD Jenkinson ◽  
C Watts ◽  
AG Marson ◽  
R Hill ◽  
K Murray ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Karnofsky Performance Status ◽  
Controlled Trial ◽  
Performance Status ◽  
Phase Iii ◽  
Glioma Surgery ◽  
Seizure Prophylaxis ◽  
Anti Epileptic Drug ◽  
Seizure Rate ◽  
Randomised Controlled

ObjectivesThere is no consensus regarding the need for prophylactic anti-epileptic drug (AED) in seizure-naive newly-diagnosed glioma patients. Data regarding prophylactic AED use are scant and inconclusive from older, small studies that enrolled patients with brain metastases, benign tumours and gliomas. A definitive randomised controlled trial (RCT) is needed to determine whether the policy of prophylactic AED therapy reduces the risk of first seizures in this population.DesignMulti-centre RCT.SubjectsInclusion criteria: i. seizure-naive, ii. supratentorial glioma suitable for surgery (biopsy/resection), iii. age ≥16 years; iv. Karnofsky performance status >60.MethodsPatients are randomised 1:1. Levetiracetam 500 mg bd for 2 weeks, increased to 750 mg bd thereafter for 1 year. Non-blinded. No placebo. Primary Outcome: one year risk of first seizure. Secondary outcomes: time to first seizure, time to first tonic-clonic seizure, mood, fatigue, quality of life, progression free survival, overall survival and incremental cost per QALY. Estimate of 1 year seizure rate in glioma after surgery is 20%. Based on a reduction in seizure rate to 10% a total of 806 patients will be recruited.ResultsGrant awarded by NIHR. Feasibility questionnaire demonstrated prophylactic AED rarely used. Neurosurgeons willing to randomise. 15 UK centres have expressed interest in participating.ConclusionsSPRING will establish class I evidence for the use of seizure prophylaxis in glioma surgery. The trial will open to recruitment in January 2019.

Surgical Target Selection in Cerebral Glioma Surgery: Linking Methionine (MET) PET Image Fusion and Neuronavigation

2007 ◽  
Vol 50 (5) ◽  
pp. 273-280 ◽  
Author(s):  
K. Roessler ◽  
B. Gatterbauer ◽  
A. Becherer ◽  
M. Paul ◽  
K. Kletter ◽  
...  
Keyword(s):  
Image Fusion ◽  
Target Selection ◽  
Cerebral Glioma ◽  
Glioma Surgery ◽  
Met Pet

Utilization of Intraoperative Motor Mapping in Glioma Surgery with High-Field Intraoperative Magnetic Resonance Imaging

2010 ◽  
Vol 88 (6) ◽  
pp. 345-352 ◽  
Author(s):  
Mustafa Aziz Hatiboglu ◽  
Jeffrey S. Weinberg ◽  
Dima Suki ◽  
Sudhakar Tummala ◽  
Ganesh Rao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Field ◽  
Resonance Imaging ◽  
Glioma Surgery ◽  
Motor Mapping ◽  
Intraoperative Magnetic Resonance Imaging

Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery

2008 ◽  
Vol 393 (1) ◽  
pp. 187-195 ◽  
Author(s):  
Stephan B. Sobottka ◽  
Kathrin D. Geiger ◽  
Reiner Salzer ◽  
Gabriele Schackert ◽  
Christoph Krafft
Keyword(s):  
Spectroscopic Imaging ◽  
Cerebral Glioma ◽  
Glioma Surgery ◽  
Infrared Spectroscopic ◽  
Infrared Spectroscopic Imaging

scholarly journals Optimizing the extent of resection and minimizing the morbidity in insular high-grade glioma surgery by high-field intraoperative MRI guidance

2016 ◽  
Author(s):  
Chen Li-feng ◽  
Yang Yang ◽  
Ma Xiao-dong ◽  
Yu Xin-guang ◽  
Gui Qiu-ping ◽  
...  
Keyword(s):  
High Field ◽  
High Grade Glioma ◽  
Extent Of Resection ◽  
Intraoperative Mri ◽  
High Grade ◽  
Glioma Surgery ◽  
Mri Guidance

High-field intraoperative MRI in glioma surgery: A prospective study with volumetric analysis of extent of resection and functional outcome

2018 ◽  
Vol 64 (3) ◽  
pp. 155-160 ◽  
Author(s):  
H.-A. Leroy ◽  
C. Delmaire ◽  
E. Le Rhun ◽  
E. Drumez ◽  
J.-P. Lejeune ◽  
...  
Keyword(s):  
Prospective Study ◽  
Functional Outcome ◽  
High Field ◽  
Extent Of Resection ◽  
Volumetric Analysis ◽  
Intraoperative Mri ◽  
Glioma Surgery ◽  
A Prospective Study

Effect of Sonographically Guided Cerebral Glioma Surgery on Survival Time

2012 ◽  
Vol 31 (5) ◽  
pp. 757-762 ◽  
Author(s):  
Jia Wang ◽  
Xi Liu ◽  
Yong Mei Ba ◽  
Yi Lin Yang ◽  
Guo Dong Gao ◽  
...  
Keyword(s):  
Survival Time ◽  
Cerebral Glioma ◽  
Glioma Surgery
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