Wuzhi Capsule (Schisandra Sphenanthera Rehder & E.H.Wilson Extract) Alleviate Mycophenolate Mofetil-Induced Intestinal Injury in Mice by Improving Oxidative Stress, Inflammation and Apoptosis

2021 ◽  
Author(s):  
Zhe Zhang ◽  
Yiyun Deng ◽  
Lijuan Feng ◽  
Yong Su ◽  
Dujuan Xu
Keyword(s):  
Oxidative Stress ◽  
Mycophenolate Mofetil ◽  
Intestinal Injury ◽  
Schisandra Sphenanthera ◽  
Wuzhi Capsule

Neonatal intestinal injury induced by maternal separation: pathogenesis and pharmacological targets

2019 ◽  
Vol 97 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Bo Li ◽  
Fang Zhou Yu ◽  
Adam Minich ◽  
Alison Hock ◽  
Carol Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Maternal Separation ◽  
Intestinal Injury ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Axis Ii ◽  
Physiological Processes ◽  
Pharmacological Targets

Maternal separation (MS) is a well-studied phenomenon thought to play a role in the pathogenesis of many diseases ranging from neuropsychiatric to early intestinal disorders such as necrotizing enterocolitis. The existing evidence suggests that MS initiates a variety of processes that in turn lead to early intestinal injury. Although there are many theories as to how MS alters normal physiological processes, the exact mechanism of action remains to be elucidated. This review aims to describe some of the pathological processes affecting the intestine that are caused by MS, including (i) brain–gut axis, (ii) intestinal epithelial barrier function, (iii) microbiome, (iv) oxidative stress and endoplasmic reticulum stress, and (v) gut inflammation.

scholarly journals Rhubarb-Aconite Decoction (RAD) Drug-Containing Serum Alleviated Endotoxin-Induced Oxidative Stress Injury and Inflammatory Response in Caco-2 Cells In Vitro

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Xiao-hong Du ◽  
Qing-jun Chen ◽  
Jian-bo Song ◽  
Yan Xie ◽  
Yan Zhi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Calcium Ion ◽  
Lipid Peroxide ◽  
Intestinal Injury ◽  
Intracellular Free Calcium ◽  
Free Calcium ◽  
Stress Injury ◽  
Oxidative Stress Injury

Rhubarb-Aconite Decoction (RAD), a famous Chinese medicine prescription, has been widely used for treating intestinal injury. However, the effect of RAD on intestinal epithelial cells is unclear. The aim of this study was to investigate the effects of RAD drug-containing serum on the oxidative stress injury and inflammatory response induced by endotoxin (ET) in Caco-2 cells in vitro. Lipid peroxide malondialdehyde (MDA), lactate dehydrogenase (LDH), caspase-11, tumor necrosis factor-α(TNF-α), interleukin-3(IL-3), and cytokeratin (CK)18, adenosine triphosphate (ATP) activity, and intracellular free calcium ion levels were measured. The results showed that ET triggered the activation of caspase-11 and the massive release of TNF-α, increased the inhibitory rate of cell growth, MDA, and LDH expressions in Caco-2 cells. Moreover, RAD drug-containing serum could inhibit caspase-11 activation, decrease the release of TNF-α and IL-3, reduce intracellular free calcium ion, and enhance CK 18 expression and ATP activity. These novel findings demonstrated that ET-induced oxidative stress injury and inflammatory response of Caco-2 cells were improved by RAD drug-containing serum, indicating that RAD may be a good choice for the treatment of intestinal injury.

scholarly journals Probiotic Bacillus Attenuates Oxidative Stress- Induced Intestinal Injury via p38-Mediated Autophagy

2019 ◽  
Vol 10 ◽  
Author(s):  
Yanping Wu ◽  
Baikui Wang ◽  
Han Xu ◽  
Li Tang ◽  
Yali Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intestinal Injury

scholarly journals Evaluation of intestinal injury, inflammatory response and oxidative stress following intracerebral hemorrhage in mice

2018 ◽  
Author(s):  
Yijun Cheng ◽  
Jieyu Zan ◽  
Yaying Song ◽  
Guoyuan Yang ◽  
Hanbing Shang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Intracerebral Hemorrhage ◽  
Intestinal Injury ◽  
And Oxidative Stress

Fibronectin Type III Domain Containing 5 Alleviates the Inflammation and Apoptosis in Lipopolysaccharide- Induced Intestinal Epithelial Cells

2020 ◽  
Vol 10 (5) ◽  
pp. 669-675
Author(s):  
Junzhi Pan ◽  
Jie Zhang
Keyword(s):  
Oxidative Stress ◽  
Cell Apoptosis ◽  
Intestinal Injury ◽  
Intestinal Epithelial ◽  
Sod Activity ◽  
Fibronectin Type Iii ◽  
Fibronectin Type Iii Domain ◽  
Related Proteins ◽  
Fibronectin Type

Intestinal injury caused by sepsis has multiple effects on the pathophysiology and development of sepsis. In this study, we aimed to explore the role of FNDC5 in progression of sepsis-induced intestinal injury. The expression of FNDC5 in blood samples of patients with sepsis-induced intestinal injury and IEC-6 cells was measured by qRT-PCR assay. Cell viability and inflammatory cytokines were evaluated by CCK-8 and ELISA assay, respectively. Oxidative stress level was detected by DCFH-DA staining and corresponding kit. Tunel assay and western blot analysis were performed to assess cell apoptosis. FNDC5 expression in patients with sepsis-induced intestinal injury was significantly decreased. The stimulation of LPS reduced expression level of FNDC5 and inhibited cell growth in IEC-6 cells. Overexpression of FNDC5 suppressed the productions of TNF-a, IL-1 , IL-6 and MCP1, diminished the level of ROS and MPO while enhanced the SOD activity. Additionally, upregulation of FNDC5 ameliorated cell apoptosis and repressed the levels of apoptosis-related proteins. FNDC5 could play a crucial role in the inflammation, oxidative stress and apoptosis in sepsis-induced intestinal injury.

Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats

2015 ◽  
Vol 40 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Liu-gen Jin ◽  
Jian-Jun Chu ◽  
Qing-feng Pang ◽  
Fu-zheng Zhang ◽  
Gang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Ionize Radiation ◽  
Caffeic Acid Phenethyl Ester ◽  
Intestinal Injury ◽  
Radiation Induced

Effect of Mycophenolate Mofetil on Glomerulosclerosis and Renal Oxidative Stress in Rats

2003 ◽  
Vol 95 (3) ◽  
pp. e93-e99 ◽  
Author(s):  
Christiane Van den Branden ◽  
Bart Ceyssens ◽  
Marina Pauwels ◽  
Greet Van Wichelen ◽  
Ingeborg Heirman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mycophenolate Mofetil

p-Coumaric acid ameliorates ionizing radiation-induced intestinal injury through modulation of oxidative stress and pyroptosis

Life Sciences ◽  
2021 ◽  
Vol 278 ◽  
pp. 119546
Author(s):  
Yun-Hong Li ◽  
Qian He ◽  
Yu-Zhong Chen ◽  
Ya-Fang Du ◽  
Ya-Xin Guo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ionizing Radiation ◽  
Intestinal Injury ◽  
Coumaric Acid ◽  
Radiation Induced

Pediococcus pentosaceus ZJUAF-4 relieves oxidative stress and restores the gut microbiota in diquat-induced intestinal injury

2021 ◽  
Vol 105 (4) ◽  
pp. 1657-1668
Author(s):  
Lihong Hao ◽  
Yuanzhi Cheng ◽  
Weifa Su ◽  
Cheng Wang ◽  
Zeqing Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Intestinal Injury ◽  
Pediococcus Pentosaceus
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