Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats

2015 ◽  
Vol 40 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Liu-gen Jin ◽  
Jian-Jun Chu ◽  
Qing-feng Pang ◽  
Fu-zheng Zhang ◽  
Gang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Ionize Radiation ◽  
Caffeic Acid Phenethyl Ester ◽  
Intestinal Injury ◽  
Radiation Induced

scholarly journals Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexandra Stähli ◽  
Ceeneena Ubaidha Maheen ◽  
Franz Josef Strauss ◽  
Sigrun Eick ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1

scholarly journals Caffeic acid phenethyl ester protects from oxidative stress and dampens inflammation via heme oxygenase 1

2018 ◽  
Vol 29 ◽  
pp. 253-253
Author(s):  
Alexandra Stähli ◽  
Ceneena Ubaidha Maheen ◽  
Franz Josef Strauss ◽  
Sigrun Eick ◽  
Anton Sculean ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1

Protective effect of Caffeic Acid Phenethyl Ester (CAPE) against oxidative stress

2017 ◽  
Vol 29 ◽  
pp. 178-184 ◽  
Author(s):  
Ana Laura Carreño ◽  
Efrain Alday ◽  
Jael Quintero ◽  
Lucía Pérez ◽  
Dora Valencia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins

2008 ◽  
Vol 86 (5) ◽  
pp. 279-287 ◽  
Author(s):  
Ting Wang ◽  
Lixiang Chen ◽  
Weimin Wu ◽  
Yuan Long ◽  
Rui Wang
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Caffeic Acid ◽  
Erythrocyte Membrane ◽  
Polyacrylamide Gel Electrophoresis ◽  
Caffeic Acid Phenethyl Ester ◽  
Water Soluble ◽  
Pbr322 Dna ◽  
Acid Esters

Oxidative stress is considered to be a major cause of cellular injuries in a variety of chronic health problems, such as carcinogenesis and neurodegenerative disorders. Caffeic acid phenethyl ester (CAPE), derived from the propolis of honeybee hives, possesses a variety of biological and pharmacological properties including antioxidant and anticancer activity. In the present study, we focused on the diverse antioxidative functionalities of CAPE and its related polyphenolic acid esters on cellular macromolecules in vitro. The effects on human erythrocyte membrane ghost lipid peroxidation, plasmid pBR322 DNA, and protein damage initiated by the water-soluble initiator 2,2′-azobis(2-amidinopropane) hydrochloride (AAPH) and hydrogen peroxide (H2O2) were monitored by formation of hydroperoxides and by DNA nicking assay, single-cell alkaline electrophoresis, and SDS-polyacrylamide gel electrophoresis. Our results showed that CAPE and its related polyphenolic acid esters elicited remarkable inhibitory effects on erythrocyte membrane lipid peroxidation, cellular DNA strand breakage, and protein fragmentation. The results suggest that CAPE is a potent exogenous cytoprotective and antigenotoxic agent against cell oxidative damage that could be used as a template for designing novel drugs to combat diseases induced by oxidative stress components, such as various types of cancer.

Caffeic acid phenethyl ester (CAPE) protects against oxidative stress induced by obesity in mice

2012 ◽  
Vol 53 ◽  
pp. S222
Author(s):  
R.M.N. Bezerra⁎ ◽  
A.C. Caetano ◽  
L.F. Veiga ◽  
F.R. Capaldi ◽  
S.M. Alencar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Obesity In Mice
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