scholarly journals A generalized kinetic model for amine modification of proteins with application to phage display

BioTechniques ◽  
2009 ◽  
Vol 46 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Xiaofang Jin ◽  
Jessica Rose Newton ◽  
Stephen Montgomery-Smith ◽  
George P. Smith
Keyword(s):  
Kinetic Model ◽  
Phage Display ◽  
Amine Modification ◽  
Generalized Kinetic Model

A generalized kinetic model for radical-initiated template polymerizations in dilute template systems

1991 ◽  
Vol 24 (7) ◽  
pp. 1641-1647 ◽  
Author(s):  
Y. Yong Tan ◽  
Gert O. R. Alberda van Ekenstein
Keyword(s):  
Kinetic Model ◽  
Generalized Kinetic Model

scholarly journals A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors

2019 ◽  
Vol 20 (19) ◽  
pp. 4911 ◽  
Author(s):  
Xie ◽  
Guo ◽  
Chen
Keyword(s):  
Kinetic Model ◽  
Atpase Activity ◽  
Single Molecule ◽  
Rate Constants ◽  
Molecular Motors ◽  
Atp Hydrolysis ◽  
Power Production ◽  
Wild Type ◽  
Chemomechanical Coupling ◽  
Generalized Kinetic Model

A general kinetic model is presented for the chemomechanical coupling of dimeric kinesin molecular motors with and without extension of their neck linkers (NLs). A peculiar feature of the model is that the rate constants of ATPase activity of a kinesin head are independent of the strain on its NL, implying that the heads of the wild-type kinesin dimer and the mutant with extension of its NLs have the same force-independent rate constants of the ATPase activity. Based on the model, an analytical theory is presented on the force dependence of the dynamics of kinesin dimers with and without extension of their NLs at saturating ATP. With only a few adjustable parameters, diverse available single molecule data on the dynamics of various kinesin dimers, such as wild-type kinesin-1, kinesin-1 with mutated residues in the NLs, kinesin-1 with extension of the NLs and wild-type kinesin-2, under varying force and ATP concentration, can be reproduced very well. Additionally, we compare the power production among different kinesin dimers, showing that the mutation in the NLs reduces the power production and the extension of the NLs further reduces the power production.

scholarly journals Kinetic Modeling of a Heterogeneous Fenton Oxidative Treatment of Petroleum Refining Wastewater

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Diya'uddeen Basheer Hasan ◽  
Abdul Aziz Abdul Raman ◽  
Wan Mohd Ashri Wan Daud
Keyword(s):  
Kinetic Model ◽  
Direct Conversion ◽  
Order Kinetic ◽  
Initial Oxidation ◽  
Oxidation Step ◽  
Kinetic Rate Constants ◽  
Order Kinetic Model ◽  
Generalized Kinetic Model ◽  
Petroleum Refinery Effluent ◽  
Kinetics Of

The mineralisation kinetics of petroleum refinery effluent (PRE) by Fenton oxidation were evaluated. Within the ambit of the experimental data generated, first-order kinetic model (FKM), generalised lumped kinetic model (GLKM), and generalized kinetic model (GKM) were tested. The obtained apparent kinetic rate constants for the initial oxidation step (k2′), their final oxidation step (k1′), and the direct conversion to endproducts step (k3′) were 10.12, 3.78, and 0.24 min−1for GKM; 0.98, 0.98, and nil min−1for GLKM; and nil, nil, and >0.005 min−1for FKM. The findings showed that GKM is superior in estimating the mineralization kinetics.

A generalized kinetic model for the formation and growth of single-walled metal oxide nanotubes

2013 ◽  
Vol 90 ◽  
pp. 200-212 ◽  
Author(s):  
G. Ipek Yucelen ◽  
Dun-Yen Kang ◽  
Ingeborg Schmidt-Krey ◽  
Haskell W. Beckham ◽  
Sankar Nair
Keyword(s):  
Kinetic Model ◽  
Metal Oxide ◽  
Metal Oxide Nanotubes ◽  
Generalized Kinetic Model

scholarly journals A Comparison and Unification of Ellipsoidal Statistical and Shakhov BGK Models

2015 ◽  
Vol 7 (2) ◽  
pp. 245-266 ◽  
Author(s):  
Songze Chen ◽  
Kun Xu ◽  
Qingdong Cai
Keyword(s):  
Kinetic Model ◽  
Flow Regime ◽  
Free Parameter ◽  
Numerical Solutions ◽  
Test Cases ◽  
Transition Flow ◽  
New Model ◽  
Transition Flow Regime ◽  
Generalized Kinetic Model ◽  
S Model

AbstractThe Ellipsoidal Statistical model (ES-model) and the Shakhov model (Smodel) were constructed to correct the Prandtl number of the original BGK model through the modification of stress and heat flux. With the introduction of a new parameter to combine the ES-model and S-model, a generalized kinetic model can be developed. This new model can give the correct Navier-Stokes equations in the continuum flow regime. Through the adjustment of the new parameter, it provides abundant dynamic effect beyond the ES-model and S-model. Changing the free parameter, the physical performance of the new model has been tested numerically. The unified gas kinetic scheme (UGKS) is employed for the study of the new model. In transition flow regime, many physical problems, i.e., the shock structure and micro-flows, have been studied using the generalized model. With a careful choice of the free parameter, good results can be achieved for most test cases. Due to the property of the Boltzmann collision integral, the new parameter in the generalized kinetic model cannot be fully determined. It depends on the specific problem. Generally speaking, the Smodel predicts more accurate numerical solutions in most test cases presented in this paper than the ES-model, while ES-model performs better in the cases where the flow is mostly driven by temperature gradient, such as a channel flow with large boundary temperature variation at high Knudsen number.

scholarly journals A Generalized Kinetic Model for Compartmentalization of Organometallic Catalysis

2021 ◽  
Author(s):  
Brandon Jolly ◽  
Chong Liu
Keyword(s):  
Kinetic Model ◽  
Organometallic Chemistry ◽  
Catalytic Performance ◽  
Side Reactions ◽  
Turnover Frequency ◽  
Organometallic Catalysis ◽  
Optimal Values ◽  
Generalized Kinetic Model ◽  
Design Guidance ◽  
Key Parameter

Compartmentalization is an attractive approach to enhance catalytic activity by retaining reactive intermediates and mitigating deactivating pathways. Such a concept has been well explored in biochemical and more recently, organometallic catalysis to ensure high reaction turnovers with minimal side reactions. However, a scarcity of theoretical framework towards confined organometallic chemistry impedes a broader utility for the implementation of compartmentalization. Herein, we report a general kinetic model and offer design guidance for a compartmentalized organometallic catalytic cycle. In comparison to a non-compartmentalized catalysis, compartmentalization is quantitatively shown to prevent the unwanted intermediate deactivation, boost the corresponding reaction efficiency (𝛾), and subsequently increase catalytic turnover frequency (𝑇𝑂𝐹). The key parameter in the model is the volumetric diffusive conductance (𝐹 ) that describes catalysts’ diffusion propensity across a compartment’s boundary. Optimal values of 𝐹 for a specific organometallic chemistry are needed to achieve maximal values of 𝛾 and 𝑇𝑂𝐹. Our model suggests a tailored compartment design, including the use of nanomaterials, is needed to suit a specific organometallic catalysis. This work provides justification and design principles for further exploration into compartmentalizing organometallics to enhance catalytic performance.

scholarly journals A generalized kinetic model describes ion-permeation mechanisms in various ion channels

2021 ◽  
Author(s):  
Di Wu
Keyword(s):  
Ion Channels ◽  
Kinetic Model ◽  
Patch Clamp ◽  
Cellular Responses ◽  
Ion Permeation ◽  
Patch Clamp Recording ◽  
Boltzmann Factor ◽  
Current Voltage ◽  
Test Voltage ◽  
Generalized Kinetic Model

Ion channels conduct various ions across biological membranes to maintain the membrane potential, to transmit the electrical signals, and to elicit the subsequent cellular responses by the signaling ions. Ion channels differ in their capabilities to select and conduct ions, which can be studied by the patch-clamp recording method that compares the current traces responding to the test voltage elicited at different conditions. In these experiments, the current-voltage curves are usually fitted by a sigmoidal function containing the Boltzmann factor. This equation is quite successful in fitting the experimental data in many cases, but it also fails in several others. Regretfully, some useful information may be lost in these data, which otherwise can reveal the ion-permeation mechanisms. Here we present a generalized kinetic model that captures the essential features of the current-voltage relations and describes the simple mechanism of the ion permeation through different ion channels. We demonstrate that this model is capable to fit various types of the patch-clamp data and explain their ion-permeation mechanisms.

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