Fascin-1 and its role as a serological marker in prostate cancer: a prospective case–control study

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.

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Diagnostic Role of Adenosine Deaminase (ADA) among Tuberculous Meningitis Patients

Bangladesh Journal of Neuroscience ◽

10.3329/bjn.v29i2.56176 ◽

2013 ◽

Vol 29 (2) ◽

pp. 79-87

Author(s):

Abul Kalam Mohammed Shoab ◽

Mohammad Shah Jahirul Hoque Chowdhury ◽

Devendra Nath Sarkar ◽

Md Ismail Hossain ◽

Muhammad Akhtaruzzaman ◽

...

Keyword(s):

Tuberculous Meningitis ◽

Case Control Study ◽

High Accuracy ◽

Case Control ◽

Specific Test ◽

Pathology Laboratory ◽

Diagnostic Role ◽

The Mean ◽

Control Study

Background: In the developing countries where TB is endemic; an ideal test for tuberculous meningitis should be economic, minimally invasive, of high accuracy and quick to perform.In many countries, also in India, several studies were conducted to establish the ADA activity as a sensitive and specific test of tuberculous meningitis.So it is very much needed to evaluate the diagnostic role of CSF ADA in tuberculous meningitis in Bangladesh. Aim: This study aimed to find out CSF ADA as a sensitive and specific test for early diagnosis of tuberculous meningitis. Methods: This case control study was carried out in the Department of Neurology, SSMC and Mitford Hospital, Dhaka from June 2011 to July 2012, to evaluate ADA activity in CSF for diagnosis of tuberculous meninigitis. Results: In the present study, sixty meningitis patients were enrolled. Of which, 30(50%) were tuberculous meningitis (TBM) taken as cases and rest 30(50%) were non-tuberculous meningitis (NTBM) taken as control.The CSF ADA activity from TBM patients was compared with CSF ADA from non-TBM infectious meningitis patients. The mean CSF ADA activity was found to be significantly higher in CSF of TBM patients, 14.01 ± 12.4 (1.0–65.2), mean ± SD with range, than in the CSF from non-TBM infectious meningitis, 7.2 ± 8.2 (1.8–49.1) P = 0.01.A cut-off value of >7.6 U/L for the TBM patients was calculated from the mean ±SD of the non-TBM patients.The ADA sensitivity is 81.82%,specificity 65.31%,accuracy 68.33%, PPV 34.62%,NPV 94.12%, positive likelyhood ratio 2.3 and lastly negative likelyhood ratio 0.2 for infectious TBM when this cut-off value was used.ROC curve shows area under curve of .736 suggests a moderate accuracy of the test in detection of tuberculous meningitis. Conclusion: This study demonstrated that ADA activity in the CSF of TBM patients, using a cut off value 7.6 U/L, can be useful for the early differential diagnosis of TBM. This test can be performed in any pathology laboratory where more sophisticated methods are not available. Bangladesh Journal of Neuroscience 2013; Vol. 29 (2) : 79-87

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Diagnostic Role of Laboratory Markers in Egyptian Patients with Mild Coronavirus Disease-2019: A Case-Control Study

Biomedical Journal of Scientific & Technical Research ◽

10.26717/bjstr.2021.35.005714 ◽

2021 ◽

Vol 35 (3) ◽

Author(s):

Hend Ibrahim Shousha

Keyword(s):

Case Control Study ◽

Case Control ◽

Laboratory Markers ◽

Egyptian Patients ◽

Diagnostic Role ◽

Control Study

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Tobacco, Alcohol, Diet and Risk of prostate Cancer

Tumori Journal ◽

10.1177/030089169508100503 ◽

1995 ◽

Vol 81 (5) ◽

pp. 315-320 ◽

Cited By ~ 43

Author(s):

Eduardo De Stefani ◽

Luis Fierro ◽

Enrique Barrios ◽

Alvaro Ronco

Keyword(s):

Prostate Cancer ◽

Tobacco Smoking ◽

National Cancer Institute ◽

Alcohol Drinking ◽

Prostatic Cancer ◽

Case Control Study ◽

Case Control ◽

Nitroso Compounds ◽

Control Study

A hospital-based case-control study of the association between tobacco smoking, alcohol drinking and several relevant dietary items and prostate cancer was carried out in the National Cancer Institute of Uruguay between January 1988 and December 1994. The sample included 156 patients with histologically proven prostatic cancer and 302 controls with a variety of neoplastic and non-neoplastic diseases. The results showed increased risks of prostate cancer associated with beer drinking, meat, milk and fruit consumption, after adjusting for major confounders. The possible role of N-nitroso compounds from beer in prostatic carcinogenesis is discussed.

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