Role of Hyperinsulinemia in Increased Risk of Prostate Cancer: A Case Control Study from Kathmandu Valley

Aim: This study aims to investigate any modification of serological FSCN1 in prostate cancer patients compared with patients without neoplasia. Material & methods: Clinical data and blood specimens from patients with and without prostate cancer were obtained. A quantitative sandwich ELISA method was used to determine serological values of FSCN1. Results: Although serum values of FSCN1 were dissimilar in the two cohorts of patients (6.90 vs 7.33 ng/ml), the difference was not statistically significant (p = 0.20). Serum values of FSCN1 stratified for Gleason score groups were not significantly distinguishable (p = 0.65). A negative correlation (rho = -0.331; p = 0.009) was reported between FSCN1 and age. Conclusion: Further studies are required to evaluate a possible diagnostic role of FSCN1 in prostate cancer.

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Oxidative Stress and Polymorphism in MTHFR SNPs (677 and 1298) in Paternal Sperm DNA is Associated with an Increased Risk of Retinoblastoma in Their Children: A Case–Control Study

Journal of Pediatric Genetics ◽

10.1055/s-0038-1667037 ◽

2018 ◽

Vol 07 (03) ◽

pp. 103-113 ◽

Cited By ~ 2

Author(s):

Shilpa Bisht ◽

Bhavna Chawla ◽

Rima Dada

Keyword(s):

Oxidative Stress ◽

Case Control Study ◽

Case Control ◽

Mthfr Gene ◽

Nucleotide Polymorphisms ◽

Mthfr Polymorphisms ◽

Sperm Dna ◽

Increased Risk ◽

Control Study

AbstractSperm DNA is considered as the most vulnerable to oxidative stress-induced damage that also impairs global sperm DNA methylation leading to sperm-associated pathologies. C677T and A1298C polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene affect MTHFR enzyme activity. This study was planned as a case–control study to determine the MTHFR gene polymorphisms in the fathers of children affected with sporadic nonfamilial heritable retinoblastoma in an Indian population. MTHFR polymorphisms for single nucleotide polymorphisms 677 and 1298 were also determined in sporadic nonfamilial heritable retinoblastoma patients to estimate the risk for retinoblastoma development and to evaluate the role of MTHFR in retinoblastoma pathogenesis.

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Helicobacter Pylori Infection and the Risk of Myocardial Infarction: Role of Fibrinogen and Its Genetic Control

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614622 ◽

1999 ◽

Vol 82 (07) ◽

pp. 14-18 ◽

Cited By ~ 17

Author(s):

Francesco Zito ◽

Augusto Di Castelnuovo ◽

Andria D’Orazio ◽

Riccardo Negrini ◽

Domenico De Lucia ◽

...

Keyword(s):

Myocardial Infarction ◽

Helicobacter Pylori ◽

Risk Factor ◽

Genetic Control ◽

Case Control Study ◽

Case Control ◽

Increased Risk ◽

Confounding Variables ◽

Control Study

SummaryThe contribution of Helicobacter pylori (HP) infection to the risk of myocardial infarction was evaluated. The role of fibrinogen and its genetic control as a possibile mechanism by which HP may influence myocardial infarction risk was explored in this context. A case-control study was performed in 101 patients with myocardial infarction and in 101 controls.HP infection was associated with an increased risk of myocardial infarction independently for confounding variables (OR 4.1, CI95: 1.8-9.4). HP infection was significantly associated with higher levels of fibrinogen, both in cases and in controls. Furthermore, there was an additive effect of HP infection and B2 allele of BclI fibrinogen poly-morphism in increasing fibrinogen levels. HP infection showed a stronger effect on the risk of myocardial infarction in B2 allele carriers (OR 7.6, CI95: 1.8-31.6) as compared to subjects carrying the B1B1 genotype (OR 3.3, CI95: 1.2-9.2).We showed that a previous HP infection is a risk factor for myocardial infarction. An increase in fibrinogen levels is a possible mechanism by which HP may act. Concomitant conditions, like a genetic predisposition in increasing fibrinogen levels, seem to further increase the effect of HP on myocardial infarction risk.

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Role of the Functional Toll-Like Receptor-9 Promoter Polymorphism (-1237T/C) in Increased Risk of End-Stage Renal Disease: A Case-Control Study

PLoS ONE ◽

10.1371/journal.pone.0058444 ◽

2013 ◽

Vol 8 (3) ◽

pp. e58444 ◽

Cited By ~ 7

Author(s):

Hsin-Yi Yang ◽

Kuo-Cheng Lu ◽

Herng-Sheng Lee ◽

Shih-Ming Huang ◽

Yuh-Feng Lin ◽

...

Keyword(s):

End Stage Renal Disease ◽

Case Control Study ◽

Promoter Polymorphism ◽

Case Control ◽

Toll Like Receptor ◽

Increased Risk ◽

Stage Renal Disease ◽

End Stage ◽

Control Study

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Androgen Deprivation Therapy and the Risk for Inguinal Hernia: An Observational Nested Case Control Study

American Journal of Men s Health ◽

10.1177/15579883211058606 ◽

2021 ◽

Vol 15 (6) ◽

pp. 155798832110586

Author(s):

Maria Hermann ◽

Hanna Vikman ◽

Pär Stattin ◽

Asmatullah Katawazai ◽

Ove Gustafsson ◽

...

Keyword(s):

Prostate Cancer ◽

Inguinal Hernia ◽

Androgen Deprivation Therapy ◽

Case Control Study ◽

Prostate Cancer Risk ◽

Case Control ◽

Androgen Deprivation ◽

Increased Risk ◽

Nested Case Control ◽

Control Study

It has been suggested that hypogonadism increases the risk for inguinal hernia (IH). The aim of this study was to investigate any association between androgen deprivation therapy (ADT) for prostate cancer and increased risk for IH. The study population in this population-based nested case-control study was based on data from the Prostate Cancer Database Sweden. The cohort included all men with prostate cancer who had not received curative treatment. Men who had been diagnosed or had undergone IH repair ( n = 1,324) were cases and controls, where not diagnosed, nor operated on for IH, matched only on birth year ( n = 13,240). Conditional multivariate logistic regression models were used to assess any temporal association between ADT and IH, adjusting for marital status, education level, prostate cancer risk category, Charlson Comorbidity Index, ADT, time since prostate cancer diagnosis, and primary prostate cancer treatment. Odds ratio (OR) for diagnosis/repair of IH 0 to 1 year from start of ADT was 0.5 (95% confidence interval [CI] = [0.38, 0.68]); between 1 and 3 years after, the OR was 0.35 (95% CI = [0.26, 0.47]); between 3 and 5 years after, the OR was 0.39 (95% CI = [0.26, 0.56]); between 5 and 7 years after, the OR was 0.6 (95% CI = [0.41, 0.97]); and >9 years after, the OR was 3.68 (95% CI = [2.45, 5.53]). The marked increase in OR for IH after 9 years of ADT supports the hypothesis that low testosterone levels increase the risk for IH. The low risk for IH during the first 8 years on ADT is likely caused by selection of men with advanced cancer unlikely to be diagnosed or treated for IH.

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Tobacco, Alcohol, Diet and Risk of prostate Cancer

Tumori Journal ◽

10.1177/030089169508100503 ◽

1995 ◽

Vol 81 (5) ◽

pp. 315-320 ◽

Cited By ~ 43

Author(s):

Eduardo De Stefani ◽

Luis Fierro ◽

Enrique Barrios ◽

Alvaro Ronco

Keyword(s):

Prostate Cancer ◽

Tobacco Smoking ◽

National Cancer Institute ◽

Alcohol Drinking ◽

Prostatic Cancer ◽

Case Control Study ◽

Case Control ◽

Nitroso Compounds ◽

Control Study

A hospital-based case-control study of the association between tobacco smoking, alcohol drinking and several relevant dietary items and prostate cancer was carried out in the National Cancer Institute of Uruguay between January 1988 and December 1994. The sample included 156 patients with histologically proven prostatic cancer and 302 controls with a variety of neoplastic and non-neoplastic diseases. The results showed increased risks of prostate cancer associated with beer drinking, meat, milk and fruit consumption, after adjusting for major confounders. The possible role of N-nitroso compounds from beer in prostatic carcinogenesis is discussed.

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