<p>Long Non-Coding RNA Cancer Susceptibility 9 (CASC9) Up-Regulates the Expression of ERBB2 by Inhibiting miR-193a-5p in Colorectal Cancer</p>

Background: RP11-108K3.2 was recently identified as a novel long non-coding RNA (lncRNA) transcript, and several single nucleotide polymorphisms (SNPs) have been identified in its coding region. This study aimed to explore the associations of tagSNPs in RP11-108K3.2 with the risk of colorectal cancer and their effects on its expression. Methods: A total of 821 colorectal cancer cases and 857 healthy controls were enrolled into this two-stage case-control study. Demographic characteristics and lifestyle information were collected by a validated questionnaire. Six tagSNPs were genotyped by using Sequenom MassARRAY platform. A total of 71 additional colorectal cancer cases were recruited, of which the genotypes of potential polymorphisms and the RP11-108K3.2 expression levels were determined. Results: In the discovery set, only the rs2470151 C/T polymorphism was found to have a promising association with the risk of colorectal cancer, and this polymorphism was further replicated in the validation set with a significantly decreased risk of colorectal cancer (adjusted odds ratio 0.73; 95% confidence interval 0.55, 0.97). Combined discovery set and validation set together, this negative association was found both in the heterozygote codominant model and the dominant model. Furthermore, colorectal cancer patients carrying rs2470151 CT/TT genotypes had a marginally lower RNA expression of RP11-108K3.2 than those carrying the CC genotype. Stratified analyses showed the association between rs2470151 and the risk of colorectal cancer were influenced by family history of cancer, smoking, alcohol consumption, and tea drinking. Conclusions: These findings suggest that RP11-108K3.2 rs2470151 had a significant association with the risk of colorectal cancer; this may help to predict the susceptibility of colorectal cancer in Chinese populations.

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Long Non-Coding RNA Cancer Susceptibility 9 (CASC9) Up-Regulates the Expression of ERBB2 by Inhibiting miR-193a-5p in Colorectal Cancer [Retraction]

Cancer Management and Research ◽

10.2147/cmar.s291181 ◽

2020 ◽

Vol Volume 12 ◽

pp. 11675-11676

Author(s):

Yuansheng Ding ◽

Xiaoyan Li ◽

Yucui Zhang ◽

Jie Zhang

Keyword(s):

Colorectal Cancer ◽

Cancer Susceptibility ◽

Non Coding Rna ◽

Long Non Coding Rna

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Four novel polymorphisms in long non-coding RNA HOTTIP are associated with the risk and prognosis of colorectal cancer

Bioscience Reports ◽

10.1042/bsr20180573 ◽

2019 ◽

Vol 39 (5) ◽

Cited By ~ 3

Author(s):

Zhi Lv ◽

Qian Xu ◽

Liping Sun ◽

Jing Wen ◽

Xinxin Fang ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Susceptibility ◽

Human Cancer ◽

Predictive Biomarkers ◽

Nucleotide Polymorphisms ◽

Specific Pcr ◽

Non Coding Rna ◽

And Function ◽

Stratified Analysis ◽

Long Non Coding Rna

AbstractBackground: The role of long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) as an oncogene in varieties of human cancer including colorectal cancer (CRC) has been extensively researched. The expression and function of lncRNAs could be affected by single nucleotide polymorphisms (SNPs), which are associated with cancer susceptibility and prognosis. However, no investigation has focused on the association between HOTTIP SNPs and CRC. The aim of the present study was to explore the association of polymorphisms in the lncRNA HOTTIP gene with CRC risk and prognosis. Methods: A total of 1848 subjects were enrolled in our study, including 884 CRC cases and 964 controls. Genotyping for five HOTTIP tagSNPs (rs3807598, rs17501292, rs2067087, rs17427960, and rs78248039) was performed by applying Kompetitive allele specific PCR (KASP). Results: The results showed three SNPs (rs3807598, rs2067087, and rs17427960) were associated with enhanced CRC risk both in overall and stratified analysis. One polymorphism, rs17501292, could improve the overall survival (OS) of CRC patients in the tumor of ulcerative/invasive-type subgroup. Conclusion: These findings suggest HOTTIP SNPs could potentially be predictive biomarkers for CRC risk and prognosis. The present study provides clues for further exploration of novel lncRNA-based genetic biomarkers to predict CRC susceptibility as well as clinical outcome.

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Berberine Promotes Apoptosis of Colorectal Cancer via Regulation of the Long Non-Coding RNA (lncRNA) Cancer Susceptibility Candidate 2 (CASC2)/AU-Binding Factor 1 (AUF1)/B-Cell CLL/Lymphoma 2 (Bcl-2) Axis

Medical Science Monitor ◽

10.12659/msm.912082 ◽

2019 ◽

Vol 25 ◽

pp. 730-738 ◽

Cited By ~ 10

Author(s):

Wei Dai ◽

Liyuan Mu ◽

Yali Cui ◽

Yingying Li ◽

Ping Chen ◽

...

Keyword(s):

Colorectal Cancer ◽

B Cell ◽

Cancer Susceptibility ◽

Non Coding Rna ◽

Binding Factor ◽

Long Non Coding Rna

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GWAS Links New Variant in Long Non-Coding RNA LINC02006 with Colorectal Cancer Susceptibility

Biology ◽

10.3390/biology10060465 ◽

2021 ◽

Vol 10 (6) ◽

pp. 465

Author(s):

Ewa E. Hennig ◽

Anna Kluska ◽

Magdalena Piątkowska ◽

Maria Kulecka ◽

Aneta Bałabas ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Susceptibility ◽

Association Studies ◽

Bioinformatic Analysis ◽

Genome Wide Association Studies ◽

Nucleotide Polymorphisms ◽

Tumor Invasiveness ◽

Non Coding Rna ◽

New Variant ◽

Long Non Coding Rna

Despite great efforts, most of the genetic factors contributing to the risk of colorectal cancer (CRC) remain undetermined. Including small but homogenous populations in genome-wide association studies (GWAS) can help us discover new common risk variants specific to the studied population. In this study, including 465 CRC patients and 1548 controls, a pooled DNA samples-based GWAS was conducted in search of genetic variants associated with CRC in a Polish population. Combined with a new method of selecting single-nucleotide polymorphisms (SNPs) for verification in individual DNA samples, this approach allowed the detection of five new susceptibility loci not previously reported for CRC. The discovered loci were found to explain 10% of the overall risk of developing CRC. The strongest association was observed for rs10935945 in long non-coding RNA LINC02006 (3q25.2). Three other SNPs were also located within genes (rs17575184 in NEGR1, rs11060839 in PIWIL1, rs12935896 in BCAS3), while one was intergenic (rs9927668 at 16p13.2). An expression quantitative trait locus (eQTL) bioinformatic analysis suggested that these polymorphisms may affect transcription factor binding sites. In conclusion, four of the identified variants were located within genes likely involved in tumor invasiveness and metastasis. Therefore, they could possibly be markers of poor prognosis in CRC patients.

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