scholarly journals Vascular Thrombosis and Anti-PD-1 Therapy: A Series of Cases

2021 ◽  
Vol Volume 13 ◽  
pp. 8849-8853
Author(s):  
Changfang Fu ◽  
Gang Wang ◽  
Wulin Yang
Keyword(s):  
2001 ◽  
Vol 21 (03) ◽  
pp. 82-96 ◽  
Author(s):  
D. Hoppensteadt ◽  
O. Iqbal ◽  
R. L. Bick ◽  
J. Fareed

SummaryThrombotic disorders are the most common cause of death in the United States. About two million individuals die each year from an arterial or venous thrombosis or related disorders. About 80% to 90% of all cases of thrombosis can now be defined with respect to cause. Of these, over 50% occur in patients who harbor a congenital or acquired blood coagulation protein or platelet defect which caused the thrombotic event. It is obviously of major importance to define those individuals harboring such a defect as this allows: 1) appropriate antithrombotic therapy to decrease risks of recurrence; 2) determination of the length of time the patient must remain on therapy for secondary prevention; and 3) allow for testing of family members of those harboring a blood coagulation protein or platelet defect which is hereditary (about 50% of all coagulation and platelet defects mentioned above). Aside from mortality, significant additional morbidity occurs from both arterial or venous thrombotic events, including, but not limited to paralysis (non-fatal thrombotic stroke), cardiac disability (repeated coronary events), loss of vision (retinal vascular thrombosis), fetal waste syndrome (placental vascular thrombosis), stasis ulcers and other manifestations of post-phlebitic syndrome, etc.


2020 ◽  
Author(s):  
Jameel Al- Ata ◽  
Gaser Abdelmohsen ◽  
Saud Bahaidarah ◽  
Naif Alkhushi ◽  
Zaher Zaher

IntroductionNeonates with congenital heart disease are at a high risk of vascular thrombosis. Thrombosis may occur due to vascular injury, increased blood viscosity secondary to polycythemia associated with congenital cyanotic heart diseases, or stasis of blood flow associated with low cardiac output (Schmidt B & Andrew M., Pediatrics 1995; 96: 939–943. Veldman A et al.,Vasc Health Risk Manag 2008; 4: 1337–1348).


1934 ◽  
Vol 30 (10) ◽  
pp. 1027-1029
Author(s):  
A. I. Petchenko

Vascular thrombosis in obstetrics and gynecology is quite common, although not always easy to recognize. In the postpartum period, after many vaginal operations we have massive thrombus formation. Placental vein thrombosis is almost physiological; slowed blood flow, decreased vascular tone after the fetus emerges, blood loss are predisposing moments to thrombosis formation in the postpartum period.


1998 ◽  
Vol 29 (8) ◽  
pp. 663-668
Author(s):  
Darius M Moshfeghi ◽  
Gholam A Peyman ◽  
Andrew A Moshfeghi ◽  
Bahram Khoobehi ◽  
George B Primbs ◽  
...  

2007 ◽  
Vol 32 (7) ◽  
pp. 1058-1060
Author(s):  
Fernando A. Herrera ◽  
Karen Horton ◽  
Ahmed Suliman ◽  
Gregory M. Buncke

2014 ◽  
Vol 3 (1) ◽  
pp. 27-36
Author(s):  
Timo Heidt ◽  
Felix Gunther ◽  
Marvin Krohn-Grimberghe ◽  
Karlheinz Peter ◽  
Christoph Bode ◽  
...  

2016 ◽  
Vol 50 (3) ◽  
pp. 127-131 ◽  
Author(s):  
M Bhanukumar ◽  
Prasanna KH Ramaswamy ◽  
Naveen K Peddi ◽  
Vineetha B Menon

ABSTRACT Aims The objective of the study was to determine the mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with type 2 diabetes mellitus (type 2 DM) compared to subjects without type 2 DM and their correlation with fasting blood glucose, glycosylated hemoglobin (HbA1c), and duration of type 2 DM respectively. Materials and methods A prospective analytical case—control study was conducted involving 50 subjects with type 2 DM and 50 subjects without type 2 DM. The mean and standard deviation were estimated for both the groups separately and independent Student's “t”-test was used for evaluating the significant difference. The statistical evaluation was carried out at 95% confidence level. Results Mean MPV and PDW in case group was significantly higher compared to control group (p < 0.005). Fasting blood glucose, HbA1c, and duration of type 2 DM did not significantly alter MPV or PDW. Conclusion The study concludes that MPV and PDW are significantly increased in patients with type 2 DM compared to patients without type 2 DM. Platelet volume indices are an important, simple, and cost-effective tool that should be used and explored extensively, especially in countries, such as India, for predicting the possibility of impending acute vascular events in patients with type 2 DM. Clinical significance This analytical method helps us to use MPV and PDW as early markers of vascular thrombosis. How to cite this article Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon VB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.


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