scholarly journals Metal complexes in cancer therapy – an update from drug design perspective

2017 ◽  
Vol Volume11 ◽  
pp. 599-616 ◽  
Author(s):  
Umar Ndagi ◽  
Ndumiso Mhlongo ◽  
Mahmoud Soliman
Keyword(s):  
Cancer Therapy ◽  
Drug Design ◽  
Metal Complexes ◽  
Design Perspective

Dual-target kinase drug design: Current strategies and future directions in cancer therapy

2020 ◽  
Vol 188 ◽  
pp. 112025 ◽  
Author(s):  
Dejuan Sun ◽  
Yuqian Zhao ◽  
Shouyue Zhang ◽  
Lan Zhang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Design ◽  
Future Directions ◽  
Dual Target

scholarly journals Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

2019 ◽  
Vol 20 (2) ◽  
pp. 341 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Sha-Sha Cheng ◽  
Fu-Wa Lee ◽  
Quan-Bin Han ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Metal Complexes ◽  
Natural Product ◽  
Cancer Care ◽  
Cancer Therapies ◽  
The Future ◽  
Therapy Development ◽  
Enhanced Selectivity

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

The progresses in curcuminoids-based metal complexes: especially in cancer therapy

2019 ◽  
Vol 11 (9) ◽  
pp. 1035-1056
Author(s):  
Yanan Zhang ◽  
Abdur Rauf Khan ◽  
Manfei Fu ◽  
Yujia Zhai ◽  
Aihua Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes

DNA Drug Design for Cancer Therapy

2005 ◽  
Vol 11 (22) ◽  
pp. 2811-2823 ◽  
Author(s):  
Y. Cho-Chung
Keyword(s):  
Cancer Therapy ◽  
Drug Design

Computer-aided drug design and ADMET predictions for identification and evaluation of novel potential farnesyltransferase inhibitors in cancer therapy

2010 ◽  
Vol 28 (6) ◽  
pp. 513-523 ◽  
Author(s):  
Carlos Henrique Tomich de Paula da Silva ◽  
Vinicius Barreto da Silva ◽  
Jonathan Resende ◽  
Patrícia Franco Rodrigues ◽  
Fernanda Cristina Bononi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Design ◽  
Farnesyltransferase Inhibitors ◽  
Computer Aided Drug Design ◽  
Computer Aided

scholarly journals Novel Metals and Metal Complexes as Platforms for Cancer Therapy

2010 ◽  
Vol 16 (16) ◽  
pp. 1813-1825 ◽  
Author(s):  
Michael Frezza ◽  
Sarmad Hindo ◽  
Di Chen ◽  
Andrew Davenport ◽  
Sara Schmitt ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes
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