scholarly journals Novel Metals and Metal Complexes as Platforms for Cancer Therapy

2010 ◽  
Vol 16 (16) ◽  
pp. 1813-1825 ◽  
Author(s):  
Michael Frezza ◽  
Sarmad Hindo ◽  
Di Chen ◽  
Andrew Davenport ◽  
Sara Schmitt ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes

scholarly journals Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

2019 ◽  
Vol 20 (2) ◽  
pp. 341 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Sha-Sha Cheng ◽  
Fu-Wa Lee ◽  
Quan-Bin Han ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Metal Complexes ◽  
Natural Product ◽  
Cancer Care ◽  
Cancer Therapies ◽  
The Future ◽  
Therapy Development ◽  
Enhanced Selectivity

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

The progresses in curcuminoids-based metal complexes: especially in cancer therapy

2019 ◽  
Vol 11 (9) ◽  
pp. 1035-1056
Author(s):  
Yanan Zhang ◽  
Abdur Rauf Khan ◽  
Manfei Fu ◽  
Yujia Zhai ◽  
Aihua Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes

Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy

ChemMedChem ◽  
2021 ◽  
Author(s):  
Ashish Kumar Yadav ◽  
Narendra Kumar ◽  
Abdul Talim Khan ◽  
Rajesh Kushwaha ◽  
Samya Banerjee
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes ◽  
Sonodynamic Therapy

scholarly journals Metal complexes in cancer therapy – an update from drug design perspective

2017 ◽  
Vol Volume11 ◽  
pp. 599-616 ◽  
Author(s):  
Umar Ndagi ◽  
Ndumiso Mhlongo ◽  
Mahmoud Soliman
Keyword(s):  
Cancer Therapy ◽  
Drug Design ◽  
Metal Complexes ◽  
Design Perspective

Metal Complexes, their Cellular Targets and Potential for Cancer Therapy

2009 ◽  
Vol 15 (7) ◽  
pp. 777-791 ◽  
Author(s):  
Di Chen ◽  
Vesna Milacic ◽  
Michael Frezza ◽  
Q. Dou
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes ◽  
Cellular Targets

Ni(II), Cu(II) and Zn(II) Complexes with 1-Trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine Ligand Simultaneously Target Microtubule and Mitochondria for Cancer Therapy

2021 ◽  
Author(s):  
Liao Lan-Shan ◽  
Yin Chen ◽  
Zu-Yu Mo ◽  
Cheng Hou ◽  
Gui-Fa SU ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Metal Complexes ◽  
Anticancer Activity

Metal complexes of [NiL2(NO3)2] (1), [CuL2(NO3)2] (2) and [ZnL2(NO3)2] (3) with 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine (L) ligand were synthesized. We discovered that complexes 13 exhibited considerable anticancer activity in vitro via simultaneously targeting...

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

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