Association Among Lipid Accumulation Product, Chinese Visceral Obesity Index and Diabetic Retinopathy in Patients with Type 2 Diabetes: A Cross-Sectional Study

Aims. To investigate the distribution of diabetic retinopathy (DR) by sex in patients with type 2 diabetes mellitus (T2DM) in a twelve-province cross-sectional study in China. Methods. Patients with T2DM, whose ages were ≥18 years, were recruited from 76 cities/counties in 12 provinces in mainland China between January 2015 and December 2018. All participants received a standardized interview, eye examinations, and digital fundus photography. The presence and severity of DR were diagnosed and classified by retina specialists according to the DR domestic typing method. Results. A total of 12,766 participants (5963 males and 6803 females) were eligible for this study. The total prevalence of DR was 30.1%. Females exhibited a significantly higher prevalence of DR than males (31.1% vs. 29.0%, P=0.011). A multivariate logistic regression analysis confirmed that female sex was an independent predictor for a higher prevalence of DR after adjusting for age, the duration of diabetes, economic status, and the presence of hypertension (OR: 1.096, 95% CI: 1.013-1.186, P=0.023). Even after stratification by the diabetic duration, age, and economic status, female sex was still independently associated with the presence of DR in patients whose T2DM history was more than 10 years, whose ages were over 60 years, or who were in a relatively intermediate economic area. Conclusion. Females had a higher prevalence of DR than males in T2DM patients with a diabetic history of more than 10 years, ages over 60 years, or a relatively intermediate economic status.

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Prevalence and associated factors of diabetic retinopathy among type 2 diabetes mellitus patients in Brunei Darussalam – A cross-sectional study

Korean Journal of Ophthalmology ◽

10.3341/kjo.2021.0040 ◽

2021 ◽

Author(s):

Sajid A Raja ◽

Vui Heng Chong ◽

Noor A. Rahman ◽

Lilabi M P Shakir ◽

Joe Knights

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Associated Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Brunei Darussalam

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Knowledge, attitude and practice in diabetic retinopathy among patients with type 2 diabetes mellitus: A hospital based cross sectional study

Indian Journal of Clinical and Experimental Ophthalmology ◽

10.18231/j.ijceo.2020.083 ◽

2020 ◽

Vol 6 (3) ◽

pp. 387-390

Author(s):

Priyamvada P V ◽

◽

Soumya H V ◽

Rajendra R ◽

Premnath Raman ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Attitude And Practice ◽

Knowledge Attitude And Practice

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Lipid accumulation product (LAP) was independently associated with obstructive sleep apnea in patients with type 2 diabetes mellitus

BMC Endocrine Disorders ◽

10.1186/s12902-020-00661-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Lianqin Dong ◽

Mingzhu Lin ◽

Wengui Wang ◽

Danyan Ma ◽

Yun Chen ◽

...

Keyword(s):

Diabetes Mellitus ◽

Linear Regression ◽

Lipid Accumulation ◽

Cross Sectional Study ◽

Regression Analyses ◽

Sectional Study ◽

Lipid Accumulation Product ◽

Cross Sectional ◽

Obstructive Sleep

Abstract Background Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mellitus (T2DM) patients. Methods A cross-sectional study of 317 T2DM patients who underwent overnight polysomnography (PSG) tests was conducted. The clinical data between non-OSA group and OSA group were compared. Multivariable linear regression and multivariable logistic regression analyses were performed to determine associations of LAP, with apnea-hypopnea index (AHI) and OSA. Results Among 317 patients, 219 (69.1%) were men, and the mean ages (±SD) were 51.4 (±13.5) years for men and 54.6 (±15.1) years for women (p = 0.067). The prevalence rates of OSA were 63.0% for men and 68.4% for women (p = 0.357). LAP (log-transformed) was significantly correlated with AHI (log-transformed), with the Pearson’s correlation coefficient of 0.170 (p = 0.002). With adjustment for potential confounding factors, multivariate linear regression analyses showed the association of LAP with AHI was not statistically significant, with the adjusted linear regression coefficients (95% CI) of per SD increase of LAP for AHI (log-transformed) was 0.092 (− 0.011–0.194, p = 0.080). Multivariate logistic regression analyses showed LAP was significantly associated with increased risk of OSA, with the adjusted OR (95%CI) of per SD increase of LAP of 1.639 (1.032–2.604, p = 0.036). However, as constituents of LAP, neither TG nor WC was significantly associated with AHI and OSA. Conclusion LAP was independently associated with OSA and might be used as a potential OSA risk marker in T2DM patients, beyond the general index of obesity.

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The Effect of Lipid Accumulation Product and Its Interaction With Family History of Hypertension on Hypertension Risk in Population With Nondiabetic in Eastern China: A Cross-sectional Study

10.21203/rs.3.rs-677854/v1 ◽

2021 ◽

Author(s):

Li Shu ◽

Lina Song ◽

Yanqi Shen ◽

Jinchen Wang ◽

Ziyan Han ◽

...

Keyword(s):

Logistic Regression ◽

Family History ◽

Lipid Accumulation ◽

Visceral Obesity ◽

Cross Sectional Study ◽

Sectional Study ◽

Lipid Accumulation Product ◽

Cross Sectional ◽

Physical Measurements ◽

History Of

Abstract Background: Lipid Accumulation Product (LAP) was proposed as a useful indicator of visceral obesity, the visceral obesity and cardiovascular diseases are closely related. However, the empirical evidences of LAP and hypertension (HTN) are limited. Our study sought to assess the risk factors of HTN and prehypertension (PHT), and provide an insight into the possible interacting influences of LAP with family history of HTN on the risk of HTN in the nondiabetic Eastern Chinese population. Methods: A large cross-sectional study was conducted in community health service centers in urban Bengbu of Anhui province, China. All elderly person aged 45 years and older were performed an interview questionnaire, physical measurements and biochemical indicators examinations by trained staffs. Common indexes to screen obese persons such as body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and LAP were calculated. Multivariate logistic regression was used to test the prevalence of HTN and PHT in relation to each quartile increase in LAP level and family history of HTN. The receiver operating characteristic (ROC) analysis was applied to calculate the best cut-off value of LAP and identify the superior obesity indicator. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). Results: 7733 subjects were enrolled in our study, the overall prevalence rates of normotension, PHT and HTN were 38.1%, 37.1% and 24.8%, respectively. The prevalence of HTN increased rapidly across LAP quartiles in males and females, the LAP values in the top quartile were significantly higher than those in the bottom quartile (31.8% vs. 17.6% in males, p for trend <0.001; 31.4% vs. 18.8% in females, p for trend <0.001). The AUC value of LAP were superior to BMI in males (Z=6.627, p<0.001) and females (Z=8.045, p<0.001). Multinomial logistic regression analysis showed that compared with subjects in LAP quartile 1, those in quartile 3 (OR: 1.612, 95% CI: 1.386-1.876) and quartile 4 (OR: 1.942, 95% CI: 1.673-2.253) had significantly higher risk of HTN (p for trend<0.001) after adjusting for confounding factors. A significant interaction was observed between LAP and family history of HTN in males (AP: 0.1663, 95% CI: 0.0027-0.3299; SI: 1.4035, 95% CI: 1.0597-1.8590) and females (RERI: 1.4109, 95% CI: 0.1455-2.9674; AP: 0.1664, 95% CI: 0.0088-0.3240; SI: 1.3884, 95% CI: 1.0565-1.8245). Conclusion: LAP is a simple and convenient index to predict the HTN risk, higher LAP values have relatively associated with higher blood pressure (BP). The results demonstrated that interactive effects of LAP with family history of HTN may synergistically influence the development of HTN.

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Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

Open Life Sciences ◽

10.2478/s11535-010-0038-9 ◽

2010 ◽

Vol 5 (4) ◽

pp. 421-426 ◽

Cited By ~ 1

Author(s):

Ines Cilenšek ◽

Amela Hercegovac ◽

Rifet Terzić ◽

Mojca Petrovič ◽

Daniel Petrovič

Keyword(s):

Type 2 Diabetes ◽

Diabetic Retinopathy ◽

Gene Polymorphisms ◽

Serum Levels ◽

Cross Sectional Study ◽

Interleukin 8 ◽

Sectional Study ◽

Interleukin 18 ◽

Cross Sectional

AbstractWe evaluated possible roles of interleukin-8 gene polymorphisms (1633T/C-rs2227543, 251A/T-rs4073) and interleukin-18 gene polymorphisms (-607C/A-rs1946518, -137G/C-rs187238) in the development of diabetic retinopathy (DR) in Caucasians with type 2 diabetes. 271 patients with DR and 113 without diabetic retinopathy were enrolled in this cross-sectional study. We did not observe an association between either interleukin-8 gene polymorphisms (1633T/C, 251A/T) or interleukin-18 gene polymorphisms (-607C/A, -137G/C) and diabetic retinopathy in Caucasians with type 2 diabetes. We did not find statistically significant differences in interleukin-8 serum levels between diabetics with the TT and AA genotype and those with other genotypes. The interleukin-18 serum levels between diabetics with the CC genotype of the -607C/A polymorphism and those with other genotypes (AA, AC) were not significantly different. Moreover, we did not observe a statistically significant effect of the tested polymorphisms of either interleukin-8 or interleukin-18 genes on serum levels in diabetics. In conclusion, our study indicates that the examined polymorphisms of interleukin-8 (1633T/C, 251A/T) and interleukin-18 (-607C/A or the -137G/C) genes are not genetic risk factors for diabetic retinopathy. Therefore, they may not be used as genetic markers for diabetic retinopathy in Caucasians with type 2 diabetes.

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