scholarly journals Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy

2016 ◽  
pp. 1793 ◽  
Author(s):  
Feng Yang ◽  
Huan Wang ◽  
Xiangui Li ◽  
Zhiqiang Ma ◽  
Dan Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Carbon ◽  
Drug Loading ◽  
Carbon Nanospheres ◽  
High Drug ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Doxorubicin Delivery ◽  
High Drug Loading

Hollow mesoporous carbon nanospheres for imaging-guided light-activated synergistic thermo-chemotherapy

Nanoscale ◽  
2019 ◽  
Vol 11 (35) ◽  
pp. 16351-16361 ◽  
Author(s):  
Yuwei Qiu ◽  
Dandan Ding ◽  
Wenjing Sun ◽  
Yushuo Feng ◽  
Doudou Huang ◽  
...  
Keyword(s):  
Mesoporous Carbon ◽  
Photoacoustic Imaging ◽  
Drug Loading ◽  
Carbon Nanospheres ◽  
High Drug ◽  
Photothermal Conversion ◽  
High Drug Loading

Hollow mesoporous carbon nanospheres were able to achieve high drug loading, excellent photoacoustic imaging ability and photothermal conversion efficacy, enabling imaging-guided light-activated synergistic therapy.

Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency

2017 ◽  
Vol 156 ◽  
pp. 29-37 ◽  
Author(s):  
Yongpeng Hou ◽  
Chen Yao ◽  
Longbing Ling ◽  
Yawei Du ◽  
Ruiyu He ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Drug ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Self Assembled ◽  
High Drug Loading

Combination therapeutics of doxorubicin with Fe3O4@chitosan@phytic acid nanoparticles for multi-responsive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88248-88254 ◽  
Author(s):  
Dandan Xu ◽  
Rui Xie ◽  
Tongying Xu ◽  
Xuejie Guo ◽  
Qi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Phytic Acid ◽  
Drug Loading ◽  
Magnetic Saturation ◽  
High Drug ◽  
Ph Response ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
High Drug Loading

Fe3O4@CS nanoparticles as the precursors were encapsulated by PA, developing Fe3O4@CS@PA nanocarriers with high drug loading efficiency, outstanding magnetic saturation, remarkable pH-response and obvious inhibition to tumor cells.

Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy

2020 ◽  
Vol 8 (3) ◽  
pp. 949-959 ◽  
Author(s):  
Yuchen Wu ◽  
Shixian Lv ◽  
Yongjuan Li ◽  
Hua He ◽  
Yong Ji ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
High Drug ◽  
Delivery Strategy ◽  
Anti Cancer ◽  
High Drug Loading

The introduction of donor-receptor coordination between micelles and drug payloads provides a precise co-delivery strategy for two different chemo-drugs with high drug loading and ROS responsiveness.

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

2019 ◽  
Vol 7 (37) ◽  
pp. 5677-5687 ◽  
Author(s):  
Li Zhang ◽  
Dongjian Shi ◽  
Chunling Shi ◽  
Tatsuo Kaneko ◽  
Mingqing Chen
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
High Drug ◽  
Release Drug ◽  
Drug Loading Efficiency ◽  
High Drug Loading

A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity

2013 ◽  
Vol 42 (24) ◽  
pp. 8918 ◽  
Author(s):  
Baixiang Wang ◽  
Weiyan Meng ◽  
Ming Bi ◽  
Yuxin Ni ◽  
Qing Cai ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
Hollow Spheres ◽  
Magnesium Silicate ◽  
Systemic Toxicity ◽  
High Drug ◽  
High Drug Loading

Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 235-244 ◽  
Author(s):  
Shuo Fang ◽  
Yongpeng Hou ◽  
Longbing Ling ◽  
Danquan Wang ◽  
Muhammad Ismail ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

scholarly journals Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

2020 ◽  
Vol 6 (45) ◽  
pp. eabc1725
Author(s):  
Yinxian Yang ◽  
Bingjun Sun ◽  
Shiyi Zuo ◽  
Ximu Li ◽  
Shuang Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Rational Design ◽  
Colloidal Stability ◽  
Drug Loading ◽  
High Drug ◽  
Tumor Selectivity ◽  
Poor Stability ◽  
High Drug Loading

Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug loading, poor stability, and poor tumor selectivity. Here, we report that simple insertion of a trisulfide bond can turn doxorubicin homodimeric prodrugs into self-assembled nanoparticles with three benefits: high drug loading (67.24%, w/w), high self-assembly stability, and high tumor selectivity. Compared with disulfide and thioether bonds, the trisulfide bond effectively promotes the self-assembly ability of doxorubicin homodimeric prodrugs, thereby improving the colloidal stability and in vivo fate of prodrug nanoassemblies. The trisulfide bond also shows higher glutathione sensitivity compared to the conventional disulfide bond, and this sensitivity enables efficient tumor-specific drug release. Therefore, trisulfide bond–bridged prodrug nanoassemblies exhibit high selective cytotoxicity on tumor cells compared with normal cells, notably reducing the systemic toxicity of doxorubicin. Our findings provide new insights into the design of advanced redox-sensitive nano-DDS for cancer therapy.

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