scholarly journals Growth Factor and Its Polymer Scaffold-Based Delivery System for Cartilage Tissue Engineering

2020 ◽  
Vol Volume 15 ◽  
pp. 6097-6111
Author(s):  
Li Chen ◽  
Jiaxin Liu ◽  
Ming Guan ◽  
Tongqing Zhou ◽  
Xin Duan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Delivery System ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Polymer Scaffold

Transforming Growth Factor Beta-Releasing Scaffolds for Cartilage Tissue Engineering

2014 ◽  
Vol 20 (2) ◽  
pp. 106-125 ◽  
Author(s):  
Henning Madry ◽  
Ana Rey-Rico ◽  
Jagadeesh K. Venkatesan ◽  
Brian Johnstone ◽  
Magali Cucchiarini
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Growth Factor Beta

The Response of Tissue Engineered Cartilage to the Temporal Application of Transforming and Insulin-Like Growth Factors

2007 ◽  
Author(s):  
Christopher J. O’Conor ◽  
Kenneth W. Ng ◽  
Lindsay E. Kugler ◽  
Gerard A. Ateshian ◽  
Clark T. Hung
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Mechanical Stimuli ◽  
Tissue Development ◽  
Engineering Research ◽  
Engineered Cartilage

Agarose has been used as an experimental scaffold for cartilage tissue engineering research due to its biocompatibility with chondrocytes, support of cartilage tissue development, and ability to transmit mechanical stimuli [1–3]. Tissue engineering studies have demonstrated that the temporal application of transforming growth factor (TGF) β3 for only 2 weeks elicits rapid tissue development that results in mechanical properties approaching native values [4]. However, it is not known whether this response to a 2-week exposure to growth factors is unique to TGF-β3. Therefore, the present study characterizes the response of tissue engineered cartilage to the temporal application of the anabolic growth factors TGF-β1, TGF-β3, and insulin-like growth factor I (IGF-I).

Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering

2010 ◽  
Vol 21 (9) ◽  
pp. 2593-2600 ◽  
Author(s):  
Sung Mook Lim ◽  
Se Heang Oh ◽  
Hee Hoon Lee ◽  
Soon Hong Yuk ◽  
Gun Il Im ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Hydrogel System

Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering

2008 ◽  
Vol 5 (5) ◽  
pp. 543-566 ◽  
Author(s):  
J Sohier ◽  
L Moroni ◽  
C van Blitterswijk ◽  
K de Groot ◽  
JM Bezemer
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Critical Factors

scholarly journals Gelatin Microsphere for Cartilage Tissue Engineering: Current and Future Strategies

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2404
Author(s):  
Shamsul Bin Sulaiman ◽  
Ruszymah Binti Haji Idrus ◽  
Ng Min Hwei
Keyword(s):  
Tissue Engineering ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
High Tendency ◽  
Gelatin Microsphere ◽  
Defect Sites ◽  
Attractive Option ◽  
Cartilage Construct

The gelatin microsphere (GM) provides an attractive option for tissue engineering due to its versatility, as reported by various studies. This review presents the history, characteristics of, and the multiple approaches to, the production of GM, and in particular, the water in oil emulsification technique. Thereafter, the application of GM as a drug delivery system for cartilage diseases is introduced. The review then focusses on the emerging application of GM as a carrier for cells and biologics, and biologics delivery within a cartilage construct. The influence of GM on chondrocytes in terms of promoting chondrocyte proliferation and chondrogenic differentiation is highlighted. Furthermore, GM seeded with cells has been shown to have a high tendency to form aggregates; hence the concept of using GM seeded with cells as the building block for the formation of a complex tissue construct. Despite the advancement in GM research, some issues must still be addressed, particularly the improvement of GM’s ability to home to defect sites. As such, the strategy of intraarticular injection of GM seeded with antibody-coated cells is proposed. By addressing this in future studies, a better-targeted delivery system, that would result in more effective intervention, can be achieved.

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