scholarly journals The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia

2020 ◽  
Vol Volume 11 ◽  
pp. 27-32
Author(s):  
Gamal Ghanem Mostafa ◽  
Fawkia Eissa Zahran ◽  
Sawsan Ahmed Omer ◽  
Ahmed Ibrahim ◽  
Heba Elhakeem
Keyword(s):  
Thyroid Hormones ◽  
Sickle Cell ◽  
Serum Ferritin ◽  
Sickle Cell Anemia ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thyroid Stimulating Hormone ◽  
Adult Males ◽  
Stimulating Hormone

scholarly journals Serum ferritin level in adult sickle cell anemia in Saudi population

2014 ◽  
Vol 5 (4) ◽  
pp. 148
Author(s):  
AhmedM Alsuliman ◽  
AbbasI Alabdultif ◽  
Mahmoud Albagshi ◽  
Abdulmottaleb Aldanden ◽  
KefahB Algadeeb
Keyword(s):  
Sickle Cell ◽  
Serum Ferritin ◽  
Sickle Cell Anemia ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Saudi Population

scholarly journals Correlation of Thyroid Hormone Derangement with Serum Ferritin Level in Children with Beta Thalassaemia Major at a Tertiary Care Hospital of Bangladesh

2013 ◽  
Vol 5 (2) ◽  
pp. 87-90
Author(s):  
AKM Rezaul Karim ◽  
Md Rafiqul Islam ◽  
Farzana Deeba ◽  
Md Hasan Jamal Fakir ◽  
Abdul Matin
Keyword(s):  
Thyroid Function ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Care Hospital ◽  
Thalassaemia Major ◽  
Stimulating Hormone

Background: Thalassaemia is a heterogeneous group of disorders. In multi-transfused thalassaemia major patients  the  thyroid  gland  function has  been  reported  to  be  normal,  decreased  reserve,  or  primary hypothyroidism.Objective: This study was an attempt to know the thyroid function status in multi-transfused thalassaemic patients and it's correlation with iron overload.Methods: This cross sectional study was carried out in the Department of Pediatrics at Bangabandhu Sheikh Mujib Medical University (BSMMU) and Transfusion centre of Bangladesh Thalassaemia Samity, Dhaka during May 2011 to April 2012. Previously diagnosed cases of thalassaemia major patients with transfusion dependent at any age with both sexes were randomly selected for this study. Serum total thyroxine (T4), total triiodothyronine (T3), thyroid stimulating hormone (TSH) and serum ferritin level were estimated from venous blood.Results: A total of 50 previously diagnosed cases of thalassaemia major patients of which 30 male and 20 female of 4 to 15 years age, transfusion dependent were randomly selected for this study. Hypothyroidism was present in 10(20%) patients.  Among  these 10 patients  compensated  primary  hypothyroidism  was  in  5(10%)  cases  and decompensate primary hypothyroidism was 5(10%) cases. The TSH value of hypothyroid patients was higher. Serum ferritin value was significantly higher in all the three groups of thalassaemic patients. There was no significant correlation between the high serum ferritin value with thyroid stimulating hormone or serum total thyroxin level.Conclusion: All transfusion dependent thalassaemic patients need periodic evaluation of thyroid  function  because  there  was  incidence  of  hypothyroidism.DOI: http://dx.doi.org/10.3329/jssmc.v5i2.20762J  Shaheed  Suhrawardy  Med  Coll 2013;5(2):87-90]

scholarly journals Association between serum ferritin level and thyroid hormones in hypothyroid pediatric patients

2021 ◽  
Vol 3 (4) ◽  
pp. 300-302
Author(s):  
Ayşegül ALPCAN ◽  
Yaşar KANDUR ◽  
Serkan TURSUN ◽  
Meryem ALBAYRAK ◽  
Ayça TÖREL ERGÜR
Keyword(s):  
Thyroid Hormones ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Pediatric Patients ◽  
Ferritin Level

scholarly journals Thyroid Function Status and Echocardiography Abnormalities in Patients with Beta Thalassemia Major in Bahrain

2013 ◽  
Vol 7 ◽  
pp. CMC.S10702 ◽  
Author(s):  
Taysir S. Garadah ◽  
Najat A. Mahdi ◽  
Ahmed M. Jaradat ◽  
Zuheir A. Hasan ◽  
Das S. Nagalla
Keyword(s):  
Regression Analysis ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Systolic Function ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Tissue Doppler ◽  
Thyroid Stimulating Hormone ◽  
Beta Thalassemia ◽  
Pulsed Doppler

Background Thyroid gland dysfunction and echocardiographic cardiac abnormalities are well-documented in patients with transfusion dependent beta-thalassemia major (β-TM). Aim This cross-sectional analytic study was conducted to investigate left ventricle (LV) diastolic and systolic function using pulsed Doppler (PD) and tissue Doppler (TD) echocardiography and correlate that with serum level thyroid stimulating hormone in patients with β-TM. Methods The study was conducted on patients with β-TM (n = 110, age 15.9 ± 8.9 years) and compared with a control group (n = 109, age 15.8 ± 8.9 years). In all participants, echocardiographic indices of PD and TD were performed and blood samples were withdrawn for measuring the serum level of TSH, free T4, and ferritin. A linear regression analysis was performed on TSH level as the dependent variable and serum ferritin as independent. Stepwise multiple regression analysis was used to determine the odds ratio of different biochemical and echo variables on the risk of developing hypothyroidism. Results Patients with β-TM compared with controls had thicker LV septal wall index (0.65 ± 0.26 vs. 0.44 ± 0.21 cm/M2, P < 0.001), posterior wall index (0.65 ± 0.23 vs. 0.43 ± 0.21 cm/m2, P < 0.01) and larger LVEDD index (4.35 ± 0.69 vs.3.88 ± 0.153 mm/m2, P < 0.001). In addition, β-TM patients had higher transmitral E wave velocity (E) (70.81 ± 10.13 vs. 57.53 ± 10.13 cm/s, P = 0.02) and E/A ratio (1.54 ± 0.18 vs. 1.23 ± 0.17, P < 0.01) and shorter deceleration time (DT) (170.53 ± 13.3 vs. 210.50 ± 19.20 m sec, P < 0.01). Furthermore, the ratio of transmitral E wave velocity to the tissue Doppler E wave at the basal septal mitral annulus (E/Em) was significantly higher in the β-TM group (19.68 ± 2.81 vs. 13.86 ± 1.41, P < 0.05). The tissue Doppler systolic wave (Sm) velocity and the early diastolic wave (Em) were significantly lower in the β-TM group compared with controls with Sm, 4.82 ± 1.2 vs. 6.22 ± 2.1 mm/sec, P < 0.05 and (Em), 3.51 ± 2.7 vs. 4.12 ± 2.5 mm/sec. P < 0.05, respectively). The tricuspid valve velocity was significantly higher in β-TM patients compared with controls 2.85 ± 0.56 vs. 1.743 ± 0.47 m sec, respectively, P < 0.01). The prevalence of subclinical hypothyroidism in patients with β-TM was 15.4%, with significantly higher mean serum TSH compared with controls (6.78 ± 1.5 vs. 3.10 ± 1.02 μIU/mL, P < 0.01) and positively correlated with the serum ferritin level ( r = 0.34, P = 0.014). On multiple regression analysis, the LV mass, LVEF%, and E/A ratio were not positive predictors of hypothyroidism in patients with β-TM. Conclusion We conclude that patients with β-TM had a high prevalence of subclinical hypothyroidism of 15.4%. Thyroid stimulating hormone was significantly high and positively correlated with the serum ferritin level. Echo cardiographic pulsed Doppler showed a restrictive LV diastolic pattern suggestive of severe diastolic dysfunction with preserved left ventricle systolic function.

scholarly journals Burden of iron overload among non-chronically blood transfused preschool children with sickle cell anaemia

2021 ◽  
Vol 21 (2) ◽  
pp. 753-758
Author(s):  
Akodu Samuel Olufemi ◽  
Adekanmbi Abiodun Folashade ◽  
Ogunlesi Tinuade Adetutu
Keyword(s):  
Preschool Children ◽  
Blood Transfusion ◽  
Iron Overload ◽  
Sickle Cell ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Sickle Cell Anaemia ◽  
Ferritin Level ◽  
Genetic Disorder ◽  
Transferrin Saturation

Background: Sickle cell disease is the commonest genetic disorder of haemoglobin due to inheritance of mutant haemo- globin genes from both parents. The disorder is characterized by chronic haemolysis which results in increased availability of iron from red blood cell destructions. Objective: To determine the prevalence of iron overload among non-chronically blood transfused preschool children with sickle cell anaemia. Methods: Serum ferritin was assayed and transferrin saturation derived in 97 steady state sickle cell anaemia children. Ele- vated iron stores were defined as serum ferritin level >300ng/ml, and transferrin saturation >45%. . Results: Serum ferritin level was greater than 300 mg/ml in 14 (14.4%) subjects and transferrin saturation >45% in six (6.2%) subjects with sickle cell anaemia. The prevalence of iron overload was 20.6%. The prevalence of iron overload was higher among subjects in older age group, female, with history of blood transfusion, and with single blood transfusion ses- sion. Conclusion: Iron overload is prevalent in older children; the number of blood transfusion sessions notwithstanding. Regu- lar assessment of serum ferritin is recommended. Keywords: Sickle cell anemia; iron overload; serum ferritin; transferrin saturation; elevated iron.

PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

Relation of Serum Ferritin Level with Serum Hepcidin and Fucose Levels in Children with β-Thalassemia Major

Hemoglobin ◽  
2021 ◽  
Vol 45 (1) ◽  
pp. 69-73
Author(s):  
Salah H. AL-Zuhairy ◽  
Mohammed A. Darweesh ◽  
Mohammed A-M. Othman
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Serum Hepcidin

Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Data

2021 ◽  
Vol 53 (04) ◽  
pp. 272-279
Author(s):  
Chaochao Ma ◽  
Xiaoqi Li ◽  
Lixin Liu ◽  
Xinqi Cheng ◽  
Fang Xue ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Dynamic Change ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Stimulating Hormone

AbstractThyroid hormone reference intervals are crucial for diagnosing and monitoring thyroid dysfunction during early pregnancy, and the dynamic change trend of thyroid hormones during pregnancy can assist clinicians to assess the thyroid function of pregnant women. This study aims to establish early pregnancy related thyroid hormones models and reference intervals for pregnant women. We established two derived databases: derived database* and derived database#. Reference individuals in database* were used to establish gestational age-specific reference intervals for thyroid hormones and early pregnancy related thyroid hormones models for pregnant women. Individuals in database# were apparently healthy non-pregnant women. The thyroid hormones levels of individuals in database# were compared with that of individuals in database* using nonparametric methods and the comparative confidence interval method. The differences in thyroid stimulating hormone and free thyroxine between early pregnant and non-pregnant women were statistically significant (p<0.0001). The reference intervals of thyroid stimulating hormone, free thyroxine and free triiodothyronine for early pregnant women were 0.052–3.393 μIU/ml, 1.01–1.54 ng/dl, and 2.51–3.66 pg/ml, respectively. Results concerning thyroid stimulating hormone and free thyroxine reference intervals of early pregnancy are comparable with those from other studies using the same detection platform. Early pregnancy related thyroid hormones models showed various change patterns with gestational age for thyroid hormones. Early pregnancy related thyroid hormones models and reference intervals for pregnant women were established, so as to provide accurate and reliable reference basis for the diagnosing and monitoring of maternal thyroid disfunction in early pregnancy.

Clinical significance of serum ferritin level as an independent predictor of insulin resistance in Korean men

2015 ◽  
Vol 107 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Sung Keun Park ◽  
Won Joon Choi ◽  
Chang-Mo Oh ◽  
Min-Gi Kim ◽  
Woo Taek Ham ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Clinical Significance ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Independent Predictor ◽  
Ferritin Level
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