scholarly journals Association between serum ferritin level and thyroid hormones in hypothyroid pediatric patients

2021 ◽  
Vol 3 (4) ◽  
pp. 300-302
Author(s):  
Ayşegül ALPCAN ◽  
Yaşar KANDUR ◽  
Serkan TURSUN ◽  
Meryem ALBAYRAK ◽  
Ayça TÖREL ERGÜR
Keyword(s):  
Thyroid Hormones ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Pediatric Patients ◽  
Ferritin Level

scholarly journals The Effect of Serum Ferritin Level on Gonadal, Prolactin, Thyroid Hormones, and Thyroid Stimulating Hormone in Adult Males with Sickle Cell Anemia

2020 ◽  
Vol Volume 11 ◽  
pp. 27-32
Author(s):  
Gamal Ghanem Mostafa ◽  
Fawkia Eissa Zahran ◽  
Sawsan Ahmed Omer ◽  
Ahmed Ibrahim ◽  
Heba Elhakeem
Keyword(s):  
Thyroid Hormones ◽  
Sickle Cell ◽  
Serum Ferritin ◽  
Sickle Cell Anemia ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thyroid Stimulating Hormone ◽  
Adult Males ◽  
Stimulating Hormone

Adverse Impact Of Elevated Pretransplantation Serum Ferritin Levels On Survival and Nonrelapse Mortality After Allogeneic Hematopoietic Stem Cell Transplantation In Children

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 2168-2168
Author(s):  
Osamu Kondo ◽  
Kohei Higuchi ◽  
Mariko Shimizu ◽  
Azusa Mayumi ◽  
Kanako Isaka ◽  
...  
Keyword(s):  
Overall Survival ◽  
Multivariate Analysis ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Pediatric Patients ◽  
Ferritin Level ◽  
Adverse Impact ◽  
Significant Prognostic Factor ◽  
Significant Difference

Abstract Background Previous studies showed an association between iron overload and hematopoietic transplant complications. Serum ferritin is widely used as an indicator for iron stores and an elevated pretransplantation level was strongly associated with inferior outcomes of transplantation in adults, though it has not been clarified well in pediatric patients. We studied prognostic impact of pretransplantation elevated ferritin levels on outcomes of allo-HSCT for pediatric hematological diseases. Patients and Methods We studied 93 consecutive pediatric patients (< 18 years old) with hematologic disease who underwent allogeneic HSCT at Osaka Medical Center and Research Institute for Maternal and Child Health between 2003 and 2009 in whom pretransplantation serum ferritin levels were available. The patients were divided into two groups, pretransplantation serum ferritin level ≥ 1000 ng/mL (SF≥1000) and ferritin level < 1000 ng/mL (SF<1000). Survival rate was estimated using the Kaplan-Meier method and compared between the two groups using the log-rank test. The association of pretransplantation ferritin and the transplant outcomes was evaluated in multivariate analysis with Cox proportional-hazards regression model. Results At 5 years after transplant, children in SF≥1000 (n=51) had a significantly lower overall survival (OS; 42.1% vs 76.6, p=0.001) and a higher non-relapse mortality (NRM; 41.0% vs 18.6%, p=0.018) than those in SF<1000 (n=42). SF≥1000 (n=20) in patients with leukemia in nonCR had lower OS (14.4% vs 75.0%, p=0.051) than SF<1000 (n=5), whereas patients in CR had almost the same OS (65.8% vs 62.2%, p=0.920) between SF≥1000 (n=14) and SF<1000 (n=14), although the sample size was too small to detect statistically significant difference. Univariate analyses revealed elevated ferritin level, leukemia, nonCR, GVHD grade 3-4 and haploidentical donor as significant worse prognostic factors for OS and cord blood transplant as a significant better factor. In multivariate analysis, an elevated pretransplantation serum ferritin level was the only significant prognostic factor for worse overall survival [HR(95%CI): 2.35 (1.05-5.27), p=0.038]. There was no significant difference in the incience of acute GVHD, infection and any other complications as causes of nonrelapse death between the two groups, although the total incidence of fatal transplant-related complications was significant higher in SF≥1000. Conclusion Our results indicate that an elevated pretransplant serum ferritin level adversely affects outcomes of allogeneic transplantation in pediatric patients as reported in adults. The adverse impact of elevated ferritin levels on survival resulted from increased NRM. The association between high ferritin levels, which are usually caused by iron overload, and outcomes of transplantation in pediatric patients requires further prospective studies. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Pharmacometabolomics for Predicting Variable Busulfan Exposure in Pediatric HSCT Patients

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2218-2218
Author(s):  
Bora Kim ◽  
Kyung Taek Hong ◽  
Ji Won Lee ◽  
Kyung-Sang Yu ◽  
In-Jin Jang ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Pediatric Patients ◽  
Conflicts Of Interest ◽  
Ferritin Level ◽  
Elevated Serum ◽  
Hematopoietic Stem ◽  
Potential Biomarker ◽  
Mitochondrial Fatty Acid

Abstract Optimal dosing for busulfan is important for minimization of systemic toxicity from overexposure and graft failure or relapse from underexposure. Herein, we investigated potential markers for predicting individual variation in the pharmacokinetics of busulfan, and suggested possible mechanism for inter-individual variability by using pharmacometabolomics. Fifty-nine pediatric patients undergoing busulfan-based conditioning chemotherapy for hematopoietic stem cell transplantation were divided into three groups according to the area under the concentration-time curve (AUC) of busulfan; low-, medium-, and high-AUC group. Nontargeted metabolic profiling of baseline urine samples showed that deferoxamine metabolites were abundant, while 2 acylcarnitines and phenylacetylglutamine were significantly lower in high-AUC group, compared with low-AUC group. Higher level of deferoxamine, an iron-chelating agent for the patients with a high serum ferritin level during the conditioning chemotherapy, suggested pharmacokinetic interaction between serum ferritin level and busulfan exposure. Retrospective analysis of the correlation between serum ferritin level and busulfan AUC showed positive correlation in 130 pediatric patients. The optimal busulfan dose to meet the target AUC of 18,750 μg*h/L/day was calculated to be 119.7 ± 30.1 mg/m2 in patients with ferritin < 1,000 ng/mL and 106.1 ± 29.3 mg/m2in patients with ferritin ≥ 1,000 ng/mL (P=0.021). Mechanismly, previous studies have indicated that ferritin, acylcarnitine and phenylacetylglutamine are closely associated with liver function. Increased serum ferritin is thought to be responsible for an increased production of oxygen free radicals and activation of GSH turnover, which means reduction of GSH levels in both plasma and erythrocytes and this depletion seems to be related to the decrease of busulfan metabolism. Down regulation of acylcarnitines is associated with deregulation of mitochondrial fatty acid β-oxidation by hepatic injury. PAGN, a marker of waste nitrogen scavenger, was down-regulated which indicates ammonia-related metabolism could also be involved in busulfan exposure. Hyperammonemia, a clinical condition of elevated ammonia levels, is mainly lead by liver cell damage. Taken together, our findings demonstrate that elevated serum ferritin levels are a potential biomarker correlated with busulfan exposure and provide some evidence that busulfan metabolism seems to decrease in the patients with reduced liver function. Disclosures No relevant conflicts of interest to declare.

PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

Relation of Serum Ferritin Level with Serum Hepcidin and Fucose Levels in Children with β-Thalassemia Major

Hemoglobin ◽  
2021 ◽  
Vol 45 (1) ◽  
pp. 69-73
Author(s):  
Salah H. AL-Zuhairy ◽  
Mohammed A. Darweesh ◽  
Mohammed A-M. Othman
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
Serum Hepcidin

Clinical significance of serum ferritin level as an independent predictor of insulin resistance in Korean men

2015 ◽  
Vol 107 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Sung Keun Park ◽  
Won Joon Choi ◽  
Chang-Mo Oh ◽  
Min-Gi Kim ◽  
Woo Taek Ham ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Clinical Significance ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Independent Predictor ◽  
Ferritin Level

scholarly journals Noninvasive assessment of iron overload by magnetic resonance imaging

2020 ◽  
Vol 19 (3) ◽  
pp. 158-163
Author(s):  
E. E. Nazarova ◽  
D. A. Kupriyanov ◽  
G. A. Novichkova ◽  
G. V. Tereshchenko
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Iron Concentration ◽  
The Body ◽  
Iron Accumulation ◽  
Resonance Imaging

The assessment of iron accumulation in the body is important for the diagnosis of iron overload syndrome or planning and monitoring of the chelation therapy. Excessive iron accumulation in the organs leads to their toxic damage and dysfunction. Until recently iron estimation was performed either directly by liver iron concentration and/or indirectly by measuring of serum ferritin level. However, noninvasive iron assessment by Magnetic resonance imaging (MRI) is more accurate method unlike liver biopsy or serum ferritin level test. In this article, we demonstrate the outlines of non-invasive diagnostics of iron accumulation by MRI and its specifications.

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population

2018 ◽  
Vol 13 (2) ◽  
pp. 222-233 ◽  
Author(s):  
Ju Young Jung ◽  
Jae-Jun Shim ◽  
Sung Keun Park ◽  
Jae-Hong Ryoo ◽  
Joong-Myung Choi ◽  
...  
Keyword(s):  
General Population ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Liver Steatosis

The Potential Clinical Significance of the Serum Iron and Ferritin Status in Lung Cancer Patients

2020 ◽  
Vol 5 (4) ◽  
pp. 189-195
Author(s):  
Fei Fei Guo ◽  
◽  
Shi Jia Cheng ◽  
Yi Ning Liu ◽  
Jiu Wei Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Stage Iv ◽  
Iron Level ◽  
Serum Iron Level ◽  
Lung Cancer Patients

Background An increasing number of studies have shown that iron, one of the indispensable trace elements in the human body, is closely related to the occurrence and development of cancer. However, few studies have clearly demonstrated the role of the iron levels in lung cancer patients, or the potential effects of inflammation on iron levels. Methods The clinical data for lung cancer patients and non-lung cancer participants were retrospectively analyzed. The serum iron and ferritin levels were measured and compared using a rank-sum test. The correlation between the serum iron/ferritin and C-reactive protein (CRP) was analyzed by rank correlation. The cut-off values for continuous variables were obtained by the receiver operating characteristic curve (ROC) method. An analysis of potential prognostic factors in lung cancer patients was conducted by univariate and multivariate survival analyses. Results The serum iron levels in patients with extensive small-cell lung cancer (SCLC) were lower than those with limited-stage SCLC, and the levels of serum ferritin and CRP in those with extensive SCLC were higher than those with limited-stage SCLC. Similarly, the serum iron levels in patients with stage IV non-small cell lung cancer (NSCLC) were lower than those of patients with stage Ⅰ-Ⅲ disease, and the levels of serum ferritin and CRP in those with stage IV NSCLC were higher than those in stages Ⅰ-Ⅲ. The serum iron level was negatively correlated with the level of CRP, while the serum ferritin level was positively correlated with CRP. The stage of lung cancer, but not the serum iron/ ferritin level, was an independent prognostic factor in lung cancer patients. Conclusions The serum iron and ferritin levels are associated with the staging of lung cancer. The later stages of lung cancer are associated with a lower serum iron level, a higher serum ferritin level, and a higher CRP level. Inflammation may play an important role in regulating the serum iron and ferritin levels in lung cancer patients.

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