PREDICTIVE SIGNIFICANCE OF HIGH SERUM FERRITIN LEVELS IN THE DEBUT OF MALIGNANT LYMPHOMA

2020 ◽  
pp. 74-81
Author(s):  
Babaeva T.N. ◽  
Seregina O.B. ◽  
Pospelova T.I.
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Prognostic Significance ◽  
Average Concentration ◽  
High Serum ◽  
Control Group ◽  
Malignant Neoplasms ◽  
Significant Prognostic Factor ◽  
Malignant Lymphomas

At present, the serum ferritin level is not included in the list of prognostic factors; however, it is known that its increased serum level in patients with malignant neoplasms relates with the tumor burden, the degree of disease activity and correlates with a worse prognosis in patients with hematologic malignancies.The normalization of serum ferritin level during remission period confirms the involving of hyperferritinemia in mechanisms of tumor progression and may testify for clinical importance of measurement of serum ferritin level in patients, including those with malignant lymphomas. Objective:The aim of this study was to assess of the prognostic significance of high ferritin levels at the onset of the disease in patients with malignant lymphomas. Materials and methods:98 patients with malignant lymphomaswere enrolled in this study, including 72 patients (73.5%) with non-Hodgkins lymphomas (NHL) and 26 patients (26.5%) with Hodgkin’s lymphoma (HL). The increased serum ferritin level (more than 350 ng/ml) was found in 53 (54.2%) patients with malignant lymphomas at the onset of disease and its average concentration was 587,62±131,6 ng/ml (8.3 times higher values of control group, p<0.001).Also the positive statistical correlationsbetween increased ferritin level and increased level of LDH (r=0.47, p<0.001, n=98) and C-reactive protein (r=0.41, p<0.001, n=98) as well as the presence of B-symptomswere found. The median OS was significantly shorter in the group of patients with increased ferritin level (more than 350 ng/ml) at the onset of disease in comparison with group of patients with normal ferritin level, where the median OS was not reach during the observation period. Patients with increased ferritin level before starting chemotherapy also showed worse results of overall survival and increased mortality risk (OR 8.122; 95% CI, 1.764-37.396;р<0.05) compare with a group of patients with ferritin level ˂350 hg/ml at the onset of disease. Conclusion:These results make it possible to include lymphomas’s patients with increased ferritin level at the onset of disease in the group with poor prognosis and lower OS, while the increased ferritin level in patients without previous blood transfusions should be considered as a significant prognostic factor.

scholarly journals Assessment of serum Ferritin level and its correlation with HbA1c in Diabetic Nephropathy

2020 ◽  
Vol 11 (2) ◽  
pp. 46-51
Author(s):  
Madhura Navule Siddappa ◽  
Kowsalya Ramprasad
Keyword(s):  
Diabetic Nephropathy ◽  
Glycemic Control ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Pearson Correlation ◽  
The Body ◽  
Control Group ◽  
Type Ii

Background: Serum ferritin levels reflecting the body iron stores, is known to be elevated in type 2 Diabetes Mellitus. However its association with diabetic complications including Diabetic nephropathy (DN), and overall glycemic control needs to be validated. Aims and Objectives: The aim of this study was to find the Serum Ferritin level abnormalities in DM patients with nephropathy in comparison with DM patients without nephropathy and to find correlation of Serum Ferritin (SF) levels with levels of Glycated Hemoglobin (HbA1c) in patients with diabetic nephropathy. Materials and Methods: This is a retrospective study, which included eighty five registered patients with Type 2 DM (44 Type II DM without nephropathy cases and 41 cases of Type II DM with nephropathy). SF and HbA1c was estimated in all cases across both the groups and were compared with age and sex matched controls and analysed. Results: Serum Ferritin levels were higher in diabetics with nephropathy compared to diabetics without nephropathy (p<0.0001). SF levels were higher in diabetic groups compared to control group (p <0.001).The correlation between HbA1c and SF was assessed among all cases of DM with nephropathy group using pearson correlation test and it showed a significantly positive correlation (r=0.431) with a SF (mean = 938±148) and HbA1c (mean = 9.2±2.02). Conclusion: Serum ferritin levels positively correlate with HbA1c levels in Type II DM cases with nephropathy, which suggests that serum Ferritin levels can be used as a surrogate marker of glycemic control in Type II DM with nephropathy.

PATTERN DYSTROPHY-LIKE CHANGES ASSOCIATED WITH VERY HIGH SERUM FERRITIN LEVEL IN β-THALASSEMIA MAJOR

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
King Hans Kurnia ◽  
Elvioza Elvioza ◽  
Mohamad Sidik ◽  
Teny Tjitra Sari ◽  
Rita Sita Sitorus
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
High Serum ◽  
Pattern Dystrophy ◽  
Very High

scholarly journals Association of Serum Ferritin Level with Acute Coronary Syndrome

2018 ◽  
Vol 32 (2) ◽  
pp. 89-93
Author(s):  
Abu Thaher Mohammad Mahfuzul Hoque ◽  
HI Lutfur Rahman Khan ◽  
Abdul Wadud Chowdhury ◽  
Md Mohshin Ahmed ◽  
Khandker Md Nurus Sabah ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Control Group ◽  
Case Group ◽  
Newly Diagnosed ◽  
College Hospital ◽  
Medical College ◽  
Coronary Syndrome

Background: A substantial number of patients get admitted in different hospitals of Bangladesh with the diagnosis of acute coronary syndrome (ACS). No underlying conventional risk factors can be identified in significant number of these patients. Therefore new emerging risk factors are likely to be involved in these patients. As many authors reported that high serum ferritin levels are associated with diabetes mellitus (DM) and hypertension (HTN), it may have role in the pathogenesis of ACS.So we designed this study to test the relation between hyperferritinemia and newly diagnosed acute coronary syndrome patients of Bangladesh.Methods: The study was an observational case control study done in Department of Cardiology, Dhaka Medical College Hospital, from January 2013 to December 2013. Newly diagnosed patients with acute coronary syndrome (ACS) in the age group of 30- 70 years, admitted in the coronary care unit (CCU) of Dhaka Medical College Hospital, Dhaka, within the study period were taken as cases and age& sex matched healthy subject with no history of ischemic heart disease (IHD) and with normal ECG were taken as control by purposive sampling. In our study, the number of cases and controls were 65 each. So, total number of subject was 130.Results: According to the serum ferritin level both cases and controls were divided into two sub groups: subjects with normal ferritin level and with hyperferritinaemia. Normal ferritin level was found in 35(53.8%) subjects of case group and 62(95.4%) subjects of control groups. Hyperferritinaemia was found in 30(46.2%) subjects of case group and 3(4.6%) subjects of control group. Hyperferritinaemia was found to be significantly higher in case group than in control group (p<0.001).Conclusion: The study concludes that the serum ferritin level of patients with ACS was significantly higher than the control group.Bangladesh Heart Journal 2017; 32(2) : 89-93

scholarly journals Detection of endocrine disorders in young children with multi-transfused thalassemia major

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Ramadan A. Mahmoud ◽  
Ashraf Khodeary ◽  
Marwa S. Farhan
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Thalassemia Major ◽  
High Serum ◽  
Endocrine Disorders ◽  
Inclusion Criteria ◽  
Poor Patient ◽  
Poor Patient Compliance ◽  
Iron Chelating Agents

Abstract Background Beta thalassemia major (TM) is the most common inherited genetic disorder worldwide. Patients are at risk of iron overload, which leads to various forms of tissue damage, including endocrinopathies. The aim of this study was to evaluate the prevalence and risk factors of endocrine disorders in young patients with multi-transfused TM receiving iron chelation therapy. Methods The inclusion criteria included all known cases of TM according to hemoglobin electrophoresis data, aged 12 years or younger, during the study period. The patient’s age, gender, parent’s consanguinity, clinical examination, and types of iron chelating agents used were recorded. Serum ferritin level, complete blood count (CBC), blood glucose homeostasis, thyroid, and parathyroid functions were determined. Results One hundred twenty patients met the inclusion criteria; 70% of them had malnutrition. The presence of endocrine disorders was observed in 28/120 (23.33%) patients. The most common endocrine disorders were thyroid disorders, either subclinical or clinical hypothyroidism in 11/120 (9.17%) patients, followed by abnormalities in glucose homeostasis 9/120 (7.5%). The prevalence of impaired glucose tolerance, impaired fasting glucose, and diabetes mellitus in the present study was 5 (4.17%), 4 (3.33%), and 0 (00%), respectively, while the least frequent endocrine disorder seen in our patients was hypoparathyroidism in 8/120 (6.66%). We noted that high serum ferritin levels and poor patient compliance to therapy were significantly associated with increased endocrine disorders (OR 0.98, 95% CI 0.96–0.99, P = 0.003 and OR 0.38, 95% CI 0.16:0.93, P = 0.03, respectively). Combined chelating iron agents significantly decreased the prevalence of endocrine disorders when compared with monotherapy (OR 0.40, 95% CI 0.16:0.97, P = 0.04). Conclusion Endocrine disorders could occur in TM patients early before or equal to 12 years of life in about one-fourth of the patients. A high serum ferritin level and poor patient compliance to therapy were significantly associated with increased endocrine disorders. Combined iron-chelating agents were associated with a decreased prevalence of endocrine disorders when compared with monotherapy.

scholarly journals Serum Ferritin Status in Microcytic Hypochromic Anaemic Medical Students

2014 ◽  
Vol 28 (1-2) ◽  
pp. 23-28
Author(s):  
Hafiza Akhter ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Tabassum Ferdous ◽  
Hasina Akhter ◽  
...  
Keyword(s):  
Young Adults ◽  
Medical Students ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Control Group ◽  
Medical College ◽  
Microcytic Hypochromic Anaemia ◽  
Hypochromic Anaemia ◽  
Significant Difference

Background: Microcytic hypochromic anaemia is common in young adults , specially in females. It is important to know the serum ferritin status of the medical students who will be involved, in future, with the health care delivery system and to prevent anaemia among them. Objective: To observe the serum ferritin status in microcytic hypochromic anaemic medical students. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2009 to June 2010. A total number of 516 apparently healthy young adults of both sexes, age ranged from 18 to 22 years , were selected for the study from two medical college in Dhaka city. Of them, 276 were nonanaemic (control group A) and 240 were anaemic (study group B). Again , anaemic (B) subjects are divided into anaemic female (B1) and anaemic male (B2) . Among the anaemic (B) subjects, 170 had normocytic normochromic , 68 had microcytic hypochromic and 2 had macrocytic hypochromic anaemia. Serum ferritin was estimated by Micro-particle Enzyme Immunoassay in subjects (68 in number) who were suffering from microcytic hypochromic anaemia. The statistical analysis was done by using unpaired ‘t’ test , Pearson’s correlation coefficient test as applicable. Result: The mean serum ferritin level was almost similar and showed no statistically significant difference between group B1 and B2. Again, a significant positive correlation of serum ferritin level with haemoglobin was observed in both female and male in microcytic hypochromic anaemic group. Conclusion: This study reveals that serum ferritin level is one of the most sensitive and accurate indicator indicating iron status and thus microcytic hypochrmic anaemia. DOI: http://dx.doi.org/10.3329/bjpp.v28i1-2.20077 Bangladesh J Physiol Pharmacol 2012; 28(1&2):23-28

Relationship between high serum ferritin level and glaucoma in a South Korean population: the Kangbuk Samsung health study

2016 ◽  
Vol 100 (12) ◽  
pp. 1703-1707 ◽  
Author(s):  
Hyo Jung Gye ◽  
Joon Mo Kim ◽  
Chungkwon Yoo ◽  
Seong Hee Shim ◽  
Yu Sam Won ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
High Serum ◽  
Korean Population ◽  
Health Study ◽  
South Korean

scholarly journals High Serum Ferritin Level is a Predictor of Early Mortality in Patients with Acute on Chronic Liver Failure

2013 ◽  
Vol 3 (1) ◽  
pp. S7
Author(s):  
Rakhi Maiwall ◽  
A. Rastogi ◽  
A.K. Chaudhary ◽  
Jaswinder Singh Maras ◽  
Chitranshu Vasisht ◽  
...  
Keyword(s):  
Liver Failure ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
High Serum ◽  
Early Mortality ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Association of High Serum Ferritin Level in Early Pregnancy with Development of Gestational Diabetes Mellitus- A Prospective Observational Study

2021 ◽  
Author(s):  
Abhijit Das ◽  
Shreyasi Karmakar ◽  
Sabyasachi Bid ◽  
Sudip Kumar Saha
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Observational Study ◽  
Serum Ferritin ◽  
Prospective Observational Study ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
High Serum ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration

Introduction: Gestational Diabetes Mellitus (GDM) has a negative impact on maternal and perinatal outcome and several long-term complications. The evidence from different experimental studies have shown that high serum ferritin concentration can lead to pancreatic β-cell dysfunction and impaired glucose metabolism leading to GDM. Aim: To determine the association of increased serum ferritin level in first trimester and GDM in course of pregnancy. Materials and Methods: A prospective observational study was conducted in 204 women in Institute of Post Graduate Medical Education and Research and SSKM Hospital, West Bengal, India, during the period from January 2015 to December 2015. The blood samples were collected and screened for GDM by Oral Glucose Tolerance Test (OGTT) at the beginning of the study and then assayed for serum ferritin level who were screened negative. The women were divided into four groups by quartiles of serum ferritin levels (Q1 to Q4). Then they were followed-up with OGTT at 24-28 weeks and again at 32-34 weeks. Statistical analysis was done by using paired t-test, Chi-square test and Fisher’s- exact test. Results: The participants had an average serum ferritin concentration of 77.44 ng/mL. GDM prevalence within each serum ferritin quartile was 7.84%, 11.76%, 19.61% and 23.53% respectively (p-value=0.016). The odds ratio for GDM in the ferritin Q2-Q4 was 1.57 (CI=0.41-5.92), 2.87 (CI=0.84-9.83) and 3.62 (CI=1.08-12.11) compared with Q1, respectively. In addition, primigravida and women with high Haemoglobin (Hb) level (>13 gm%) have an increased risk of developing GDM. Conclusion: Elevated serum ferritin level is associated with increased incidence of GDM irrespective of other risk factors. Iron supplementation should therefore be individualised based on serum ferritin in early pregnancy to minimise the risk of GDM.

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