Relationship Between Prognostic Nutritional Index and Mortality in Overweight or Obese Patients with Cancer: A Multicenter Observational Study

AbstractVenous thromboembolism (VTE) is common in patients with cancer and is a leading cause of death. In addition to the hypercoagulable state associated with malignancy, cancer-related surgery and subsequent immobilization further increase the risk of VTE. Guidelines suggest extended prophylaxis up to 4 weeks with low-molecular-weight heparin (LMWH) in such patients. This study is conducted to determine the proportion of patients receiving thromboprophylaxis among those undergoing surgery for malignant abdominal or pelvic tumor. This prospective, multicenter, observational study included 300 patients (217 [72.3%] were women). Mean age and duration of cancer were 53.2 and 1.2 years, respectively. A total of 162 (54%) patients received thromboprophylaxis of which only pharmacological in 78 [48.1%], only mechanical in 27 [16.7%], and both pharmacological and mechanical in 57 [35.2%] patients. LMWH (128, 79.0%) and graduated compression stockings (74, 45.7%) were the commonly used modalities. VTE prophylaxis was given in only half of the patients. Physician education to increase adherence to international guidelines is very important. Trial Registration No. CTRI/2013/05/003617.

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Diet and Nutrition Advice After a Solid Tumor Diagnosis

JCO Oncology Practice ◽

10.1200/op.20.00685 ◽

2021 ◽

pp. OP.20.00685

Author(s):

Amy Mullee ◽

Aidan O’Donoghue ◽

Pauline Uí Dhuibhir ◽

Niamh O’Donoghue ◽

Deirdre Burke ◽

...

Keyword(s):

Observational Study ◽

Dietary Supplements ◽

Solid Tumor ◽

Healthcare Professionals ◽

Tumor Diagnosis ◽

Evidence Based ◽

Multicenter Observational Study ◽

Patients With Cancer ◽

Item Questionnaire ◽

Nutrition Impact Symptoms

PURPOSE: Credible evidence-based diet and nutrition advice is essential for patients with cancer. This study aimed to explore what advice patients with cancer obtained before a formal dietetic visit. METHODS: A multicenter, observational study was conducted in seven hospital-based oncology services. Consecutive patients were recruited at first dietetic assessment. In addition to routine dietetic assessment, participants completed a four-item questionnaire describing diet and nutrition advice obtained since diagnosis. RESULTS: Seventy-seven patients participated. More than 80% had multiple nutrition-impact symptoms. In total, 53 (69%) obtained advice from professional and nonprofessional sources before dietetic visit. Family and friends were the most common sources of advice. More than one third got advice from (nondietetic) healthcare professionals. Most advice related to “foods to include” (61%) and “foods to avoid” (54%) in the diet. Many of the “foods to avoid” were important sources of micro- and macronutrients. Advice about dietary supplements (31%) and specific diets (28%) was common, rarely evidence-based, and frequently contradictory. Participants found it difficult to discern what advice was trustworthy and reliable. Despite this, most followed the advice. CONCLUSION: The majority of patients received diet and nutrition advice before first dietetic visit. Most of this came from nonprofessional sources. Any advice from nondietetic healthcare professionals was inconsistent or vague. This was mainly related to the avoidance and/or inclusion of particular foods and was often contradictory. Nevertheless, patients usually followed such advice fully. To help manage their frequent nutrition-impact symptoms and resolve the contradictory advice they had received, many expressed the need for earlier professional dietetic consultation.

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Investigation of Optimal Time for Starting Betamethasone Using Fatigue Scores and Prognostic Nutritional Index in Terminally Ill Patients With Cancer-Related Fatigue

American Journal of Hospice and Palliative Medicine® ◽

10.1177/1049909116632487 ◽

2016 ◽

Vol 34 (5) ◽

pp. 449-455 ◽

Cited By ~ 2

Author(s):

Nanako Koyama ◽

Chikako Matsumura ◽

Hiroaki Morii ◽

Chiaki Hasegawa ◽

Daiki Hira ◽

...

Keyword(s):

Survival Time ◽

Terminally Ill ◽

Prognostic Nutritional Index ◽

Optimal Time ◽

Clinical Validity ◽

Patients With Cancer ◽

Terminally Ill Patients ◽

Cancer Related Fatigue ◽

Nutritional Index ◽

The Relationship

Background: Corticosteroids are frequently used to treat cancer-related fatigue (CRF), but it is yet to be established as standard care, and few reports have defined the appropriate time to start treatment. Objectives: We investigated the optimal time for starting betamethasone and evaluated the clinical validity of using the prognostic nutritional index (PNI) for this purpose. Methods: Data were retrospectively collected for patients with terminal cancer receiving betamethasone for palliative care. Fatigue strength was evaluated by the daily occurrence of fatigue, using proportion of adequate fatigue, AF(%), defined as the average of the daily score for all treatment days, AF(%)all, the initial 5 days, AF(%)initi5, or the last 5 days, AF(%)last5. We examined (1) the relationship between survival time and adequate fatigue for CRF and (2) the correlation between survival time and PNI (based on serum albumin and lymphocytes). Results: Data from 24 patients were included. The AF(%)all was approximately 50% at 42 days before death and gradually decreased as the survival time shortened ( R2 =.41, P <.001). There was a clear positive correlation between AF(%)all and AF(%)initi5 ( R2 =.84, P <.001). At 42 days before death, PNI was approximately 30 and significantly correlated with the survival time ( R2 = .873, P <.001). Conclusion: The adequate fatigue appears to be dependent on survival time, and PNI might be useful for identifying patients that will benefit from betamethasone use. It is hoped that these results will contribute to individualized pharmacotherapy of terminally ill patients with CRF.

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Normal reference intervals of prognostic nutritional index in healthy adults: A large multi‐center observational study from Western China

Journal of Clinical Laboratory Analysis ◽

10.1002/jcla.23830 ◽

2021 ◽

Author(s):

Guishu Yang ◽

Dongsheng Wang ◽

Linbo He ◽

Guangjie Zhang ◽

Jianhong Yu ◽

...

Keyword(s):

Observational Study ◽

Prognostic Nutritional Index ◽

Reference Intervals ◽

Healthy Adults ◽

Western China ◽

Nutritional Index ◽

Normal Reference

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Lumbar Microdiscectomy in Obese Patients: A Multicenter Observational Study

World Neurosurgery ◽

10.1016/j.wneu.2017.11.156 ◽

2018 ◽

Vol 110 ◽

pp. e1004-e1010 ◽

Cited By ~ 3

Author(s):

Mattis A. Madsbu ◽

Lise R. Øie ◽

Øyvind Salvesen ◽

Vetle Vangen-Lønne ◽

Øystein P. Nygaard ◽

...

Keyword(s):

Observational Study ◽

Obese Patients ◽

Multicenter Observational Study ◽

Lumbar Microdiscectomy

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A clinical investigation of the association between perioperative oral management and prognostic nutritional index in patients with digestive and urinary cancers

Current Oncology ◽

10.3747/co.27.5963 ◽

2020 ◽

Vol 27 (5) ◽

Author(s):

H. Otagiri ◽

S. Yamada ◽

M. Hashidume ◽

A. Sakurai ◽

M. Morioka ◽

...

Keyword(s):

Postoperative Period ◽

Medical Records ◽

Clinical Investigation ◽

Oral Intake ◽

Prognostic Nutritional Index ◽

Early Postoperative Period ◽

Patients With Cancer ◽

Positive Effects ◽

Management Interventions ◽

Nutritional Index

Background The prognostic nutritional index (pni) is a simple metric calculated using serum albumin and the peripheral lymphocyte count. It was reported that a low pni score is significantly associated with major postoperative complications and poor prognosis. The purpose of the present study was to investigate the effects of perioperative oral management (pom) on the perioperative pni profiles of patients with digestive system or urinary cancers. Study Design The medical records of 181 patients with cancer who underwent surgery and for whom a pni could be calculated were retrospectively reviewed. Results The intervention rate with pom was 34.8%. The median preoperative pni score was 48.25 in all patients with a pom intervention [25% to 75% interquartile range (iqr): 44.38–54.13] and 47.25 in those without an intervention (iqr: 42.0–53.5). Compared with patients not receiving pom, those who received pom had significantly higher pni scores from the early postoperative period (p < 0.05). Notably, of patients who could resume oral intake within 3 days after surgery, those who received pom intervention, compared with those who did not, had significantly higher pni scores from the early postoperative period (p < 0.05). Conclusions Perioperative oral management interventions might have positive effects on the postoperative pni scores of patients with cancer.

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