scholarly journals Delivery of bevacizumab by intracranial injection: assessment in glioma model

2018 ◽  
Vol Volume 11 ◽  
pp. 2673-2683 ◽  
Author(s):  
Yu-xiao Liu ◽  
Wen-jia Liu ◽  
Hui-ru Zhang ◽  
Zhi-wen Zhang
Keyword(s):  
Intracranial Injection ◽  
Glioma Model

scholarly journals Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects

2010 ◽  
Vol 24 (5) ◽  
pp. 473-482 ◽  
Author(s):  
Benjamin Lemasson ◽  
Thomas Christen ◽  
Xavier Tizon ◽  
Régine Farion ◽  
Nadège Fondraz ◽  
...  
Keyword(s):  
Drug Effects ◽  
Multiparametric Mri ◽  
Human Glioma ◽  
Glioma Model

scholarly journals Exogenous Transforming Growth Factor-β in Brain-Induced Symptoms of Central Fatigue and Suppressed Dopamine Production in Mice

2021 ◽  
Vol 22 (5) ◽  
pp. 2580
Author(s):  
Won Kil Lee ◽  
Yeongyeong Kim ◽  
Heejin Jang ◽  
Joo Hye Sim ◽  
Hye Jin Choi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Neuroblastoma Cell ◽  
Critical Role ◽  
Central Fatigue ◽  
Chronic Fatigue ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Intracranial Injection ◽  
Tgf Β1

Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is one of the most refractory diseases in humans and is characterized by severe central fatigue accompanied with various symptoms that affect daily life, such as impaired memory, depression, and somatic pain. However, the etiology and pathophysiological mechanisms of CFS remain unknown. To investigate the pathophysiological role of transforming growth factor (TGF)-β1, we injected a cytokine into the lateral ventricle of a C57BL/6 mouse. The intracranial injection of TGF-β1 increased the immobility duration in a forced swimming test (FST) and time spent at the closed arm in elevated plus maze (EPM) analysis. The mice injected with TGF-β1 into their brain showed increased sensitivity to pain in a von Frey test, and had a decreased retention time on rotarod and latency time in a bright box in a passive avoidance test. In addition, the serum levels of muscle fatigue biomarkers, lactate dehydrogenase (LDH) and creatine kinase (CK), were significantly increased after administration of TGF-β1. Intracranial injection of TGF-β1 significantly reduced the production of tyrosine hydroxylase (TH) in the ventral tegmental area, accompanied by a decreased level of dopamine in the striatum. The suppression of TH expression by TGF-β1 was confirmed in the human neuroblastoma cell line, SH-SY5Y. These results, which show that TGF-β1 induced fatigue-like behaviors by suppressing dopamine production, suggest that TGF-β1 plays a critical role in the development of central fatigue and is, therefore, a potential therapeutic target of the disease.

BCNU-POLYMER AND CONCURRENT RADIATION THERAPY PROLONG SURVIVAL IN A MALIGNANT GLIOMA MODEL

1996 ◽  
Vol 89 (Supplement) ◽  
pp. S66-S67
Author(s):  
Matthew G. Ewend ◽  
Jeffery Williams ◽  
Betty Tyler ◽  
Richard Anderson ◽  
Khosrow Tabassi ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Malignant Glioma ◽  
Glioma Model

scholarly journals Acute Temporal Changes of MRI-Tracked Tumor Vascular Parameters after Combined Anti-angiogenic and Radiation Treatments in a Rat Glioma Model: Identifying Signatures of Synergism

2017 ◽  
Vol 187 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Rasha Elmghirbi ◽  
Tavarekere N. Nagaraja ◽  
Stephen L. Brown ◽  
Swayamprava Panda ◽  
Madhava P. Aryal ◽  
...  
Keyword(s):  
Temporal Changes ◽  
Rat Glioma ◽  
Glioma Model ◽  
Radiation Treatments

scholarly journals Double minute amplification of mutant PDGF receptor α in a mouse glioma model

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Hongyan Zou ◽  
Rui Feng ◽  
Yong Huang ◽  
Joseph Tripodi ◽  
Vesna Najfeld ◽  
...  
Keyword(s):  
Pdgf Receptor ◽  
Double Minute ◽  
Glioma Model ◽  
Mouse Glioma

scholarly journals A Syngeneic Mouse Glioma Model for Study of Glioblastoma Therapy

1999 ◽  
Vol 58 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Ned E. Weiner ◽  
Richard B. Pyles ◽  
Claudia L. Chalk ◽  
M Gregory Balko ◽  
Mary Ann Miller ◽  
...  
Keyword(s):  
Syngeneic Mouse ◽  
Glioma Model ◽  
Mouse Glioma

Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model

2010 ◽  
Vol 288 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Chung Kwon Kim ◽  
Young Ae Joe ◽  
Suk-Keun Lee ◽  
Eun-Kyoung Kim ◽  
Eunju O ◽  
...  
Keyword(s):  
Low Dose ◽  
Kringle Domain ◽  
Dose Combination ◽  
Glioma Model ◽  
Anti Tumor Activity

scholarly journals In vivo detection of c-Met expression in a rat C6 glioma model

2007 ◽  
Vol 12 (1) ◽  
pp. 174-186 ◽  
Author(s):  
R.A. Towner ◽  
N. Smith ◽  
S. Doblas ◽  
Y. Tesiram ◽  
P. Garteiser ◽  
...  
Keyword(s):  
C6 Glioma ◽  
In Vivo Detection ◽  
Glioma Model ◽  
Rat C6 Glioma

scholarly journals Behavioral and biochemical effects of intracranial injection of cytosine arabinoside in goldfish.

1968 ◽  
Vol 60 (4) ◽  
pp. 1389-1395 ◽  
Author(s):  
L. Casola ◽  
R. Lim ◽  
R. E. Davis ◽  
B. W. Agranoff
Keyword(s):  
Cytosine Arabinoside ◽  
Intracranial Injection ◽  
Biochemical Effects
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