scholarly journals Role of calcium-dependent protein kinases in chronic myeloid leukemia: combined effects of PKC and BCR-ABL signaling on cellular alterations during leukemia development

2014 ◽  
pp. 1247 ◽  
Author(s):  
Andre Mencalha ◽  
Stephany Correa ◽  
Eliana Abdelhay
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Protein Kinases ◽  
Myeloid Leukemia ◽  
Combined Effects ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Leukemia Development ◽  
Calcium Dependent Protein Kinases ◽  
Cellular Alterations

scholarly journals The Role of Calcium/Calcium-Dependent Protein Kinases Signal Pathway in Pollen Tube Growth

2021 ◽  
Vol 12 ◽  
Author(s):  
Hao Yang ◽  
Chen You ◽  
Shaoyu Yang ◽  
Yuping Zhang ◽  
Fan Yang ◽  
...  
Keyword(s):  
Pollen Tube ◽  
Protein Kinases ◽  
Signal Pathway ◽  
Signaling Networks ◽  
Biological Processes ◽  
Signal Molecule ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases

Pollen tube (PT) growth as a key step for successful fertilization is essential for angiosperm survival and especially vital for grain yield in cereals. The process of PT growth is regulated by many complex and delicate signaling pathways. Among them, the calcium/calcium-dependent protein kinases (Ca2+/CPKs) signal pathway has become one research focus, as Ca2+ ion is a well-known essential signal molecule for PT growth, which can be instantly sensed and transduced by CPKs to control myriad biological processes. In this review, we summarize the recent progress in understanding the Ca2+/CPKs signal pathway governing PT growth. We also discuss how this pathway regulates PT growth and how reactive oxygen species (ROS) and cyclic nucleotide are integrated by Ca2+ signaling networks.

THE ROLE OF CALCIUM DEPENDENT PROTEIN KINASES IN THE REGULATION OF MUSCLE GLYCOGEN METABOLISM

1978 ◽  
pp. 119-127
Author(s):  
Ludwig M.G. Heilmeyer ◽  
Magdolna Varsànyi ◽  
Ute Gröschel-Stewart ◽  
Manfred Kilimann ◽  
Assadollah Djovkar ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Muscle Glycogen ◽  
Glycogen Metabolism ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases

Calcium-Dependent Protein Kinases (CDPK) in Abiotic Stress Tolerance

2018 ◽  
Vol 34 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Hemant B Kardile ◽  
◽  
Vikrant ◽  
Nirmal Kant Sharma ◽  
Ankita Sharma ◽  
...  
Keyword(s):  
Abiotic Stress ◽  
Stress Tolerance ◽  
Protein Kinases ◽  
Abiotic Stress Tolerance ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases

A REVIEW ON THE ROLE OF TYROSINE KINASE INHIBITORS AVAILABLE FOR THE MANAGEMENT OF CHRONIC MYELOID LEUKEMIA

2020 ◽  
Vol 7 (2) ◽  
pp. 205-211
Author(s):  
Kaynat Fatima ◽  
Syed Tasleem Raza ◽  
Ale Eba ◽  
Sanchita Srivastava ◽  
Farzana Mahdi
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Protein Kinases ◽  
Tyrosine Kinase Inhibitors ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

The function of protein kinases is to transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are linked to the initiation and development of human cancer. The recent development of small molecule kinase inhibitors for the treatment of different types of cancer in clinical therapy has proven successful. Significantly, after the G-protein-coupled receptors, protein kinases are the second most active category of drug targets. Imatinib mesylate was the first tyrosine kinase inhibitor (TKI), approved for chronic myeloid leukemia (CML) treatment. Imatinib induces appropriate responses in ~60% of patients; with ~20% discontinuing therapy due to sensitivity, and ~20% developing drug resistance. The introduction of newer TKIs such as, nilotinib, dasatinib, bosutinib, and ponatinib has provided patients with multiple options. Such agents are more active, have specific profiles of side effects and are more likely to reach the necessary milestones. First-line treatment decisions must be focused on CML risk, patient preferences and comorbidities. Given the excellent result, half of the patients eventually fail to seek first-line treatment (due to discomfort or resistance), with many of them needing a third or even further therapy lines. In the present review, we will address the role of tyrosine kinase inhibitors in therapy for chronic myeloid leukemia.

Widespread Distribution of the 14-3-3 Protein in Vertebrate Brains and Bovine Tissues: Correlation with the Distributions of Calcium-Dependent Protein Kinases

1991 ◽  
Vol 56 (4) ◽  
pp. 1449-1451 ◽  
Author(s):  
Tohru Ichimura ◽  
Hiroshi Sugano ◽  
Ryozo Kuwano ◽  
Toshiyuki Sunaya ◽  
Tsuneo Okuyama ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Widespread Distribution ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases

Mitogen-activated protein kinases and calcium-dependent protein kinases are involved in wounding-induced ethylene biosynthesis inArabidopsis thaliana

2017 ◽  
Vol 41 (1) ◽  
pp. 134-147 ◽  
Author(s):  
Sen Li ◽  
Xiaofei Han ◽  
Liuyi Yang ◽  
Xiangxiong Deng ◽  
Hongjiao Wu ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Ethylene Biosynthesis ◽  
Mitogen Activated Protein Kinases ◽  
Calcium Dependent ◽  
Mitogen Activated Protein ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases

Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites

2011 ◽  
pp. 319-333
Author(s):  
Dominik Kugelstadt ◽  
Bianca Derrer ◽  
Barbara Kappes
Keyword(s):  
Protein Kinases ◽  
Drug Targets ◽  
Apicomplexan Parasites ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Calcium Dependent Protein Kinases
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