scholarly journals No Association Between FTO Gene Polymorphisms and Central Nervous System Tumor Susceptibility in Chinese Children

2021 ◽  
Vol Volume 14 ◽  
pp. 109-115
Author(s):  
Yuxiang Liao ◽  
Li Yuan ◽  
Zhiping Zhang ◽  
Ao Lin ◽  
Jingying Zhou ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Polymorphisms ◽  
Chinese Children ◽  
Central Nervous System Tumor ◽  
Fto Gene ◽  
Tumor Susceptibility ◽  
System Tumor

scholarly journals Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility

2021 ◽  
Author(s):  
Huiran Lin ◽  
Huitong Chen ◽  
Ao Lin ◽  
Xiaoping Liu ◽  
Xiaokai Huang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Polymorphisms ◽  
Central Nervous System Tumor ◽  
Tumor Susceptibility ◽  
System Tumor

scholarly journals AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yong-Ping Chen ◽  
Li Yuan ◽  
Hui-Ran Lin ◽  
Xiao-Kai Huang ◽  
Ji-Chen Ruan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chinese Children ◽  
Cns Tumors ◽  
Childhood And Adolescence ◽  
Control Analysis ◽  
Central Nervous System Tumor ◽  
Nucleotide Polymorphisms ◽  
Cns Tumor ◽  
Tumor Susceptibility

Abstract Introduction Central nervous system (CNS) tumors comprise 15–20% of all malignancies occurring in childhood and adolescence. Previous researches have shown that overexpression and amplification of the AURKA gene could induce multiple human malignancies, with which the connection of CNS tumor susceptibility has not been extensively studied. Material and methods In this study, we assessed whether and to what extent AURKA gene single nucleotide polymorphisms (SNPs) (rs1047972 C > T, rs2273535 T > A, rs8173 G > C) were associated with CNS tumor susceptibility, based on a case–control analysis in 191 CNS tumor patients and 248 controls. We determined this correlation using odds ratios (ORs) and 95% confidence intervals (CIs). Results AURKA gene rs8173 G > C exhibited a crucial function to CNS tumor susceptibility fall-off (GC/CC vs. GG: adjusted OR = 0.68, 95% CI = 0.46–0.998, P = 0.049). In addition, the combined effect of lowering the risk of developing CNS tumors was more pronounced in carriers with 3 protective genotypes than others (adjusted OR = 0.55, 95% CI = 0.31–0.98, P = 0.044). Further stratification analysis illustrated that the existence of rs8173 GC/CC and three protective genotypes lowered CNS tumor risk in some subgroups. Conclusions Our research suggested that the AURKA gene rs8173 G > C could significantly reduce CNS tumor susceptibility in Chinese children. More functional experiments are needed to explore the role of the AURKA gene rs8173 G > C.

scholarly journals Central liponeurocytoma: Case report and review of literature

2012 ◽  
Vol 01 (01) ◽  
pp. 083-085 ◽  
Author(s):  
Pankaj Ailawadhi ◽  
M.C. Sharma ◽  
A.K. Mahapatra ◽  
P. Sarat Chandra
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Classification ◽  
Central Nervous System Tumor ◽  
The Central Nervous System ◽  
Cerebellar Liponeurocytoma ◽  
Classification Of Tumors ◽  
System Tumor ◽  
Well Differentiated ◽  
Glioneuronal Tumors

Abstract Cerebellar liponeurocytoma consists of well-differentiated neurons with the cytology of neurocytes in addition to a population of lipidized cells. Hence it is biphasic in appearance and has been included in the category of glioneuronal tumors of the central nervous system by the WHO working group on the Classification of Tumors of the Nervous System. However, liponeurocytoma is not exclusive to the cerebellar or fourth ventricular location. Since its inclusion in the central nervous system tumor classification, nine cases with similar histological and immunohistochemical features have also been described in the lateral ventricles. We describe here such a lateral ventricular tumour in a 30-year-old woman, characteristically showing divergent glio-neuronal differentiation and lipidized neoplastic cells. Therefore, we suggest that future WHO tumor classification should consider that liponeurocytomas are not entirely restricted to the cerebellum and henceforth change of nomenclature might be considered, as also pointed out by other authors.

An Unusual Case of a Central Nervous System Tumor Presenting as a Chief Complaint of Depression

2007 ◽  
Vol 23 (7) ◽  
pp. 486-488 ◽  
Author(s):  
Nicolas M. Oreskovic ◽  
Christopher G. Strother ◽  
Lara M. Zibners
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Unusual Case ◽  
Chief Complaint ◽  
Central Nervous System Tumor ◽  
System Tumor

scholarly journals Multimodal Analysis of Central Nervous System Tumor Tissue Endogenous Fluorescence With Multiscale Excitation

2018 ◽  
Vol 6 ◽  
Author(s):  
Fanny Poulon ◽  
Audrey Chalumeau ◽  
Frederic Jamme ◽  
Johan Pallud ◽  
Pascale Varlet ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Tissue ◽  
Central Nervous System Tumor ◽  
Multimodal Analysis ◽  
System Tumor ◽  
Endogenous Fluorescence

Hypercoaulability state in central nervous system tumor patients

1997 ◽  
Vol 99 ◽  
pp. S251
Author(s):  
M.E. Kusak ◽  
J.M. Alonso ◽  
D. Santamarta ◽  
I. Recio ◽  
J.M. Borrás ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumor ◽  
Tumor Patients ◽  
System Tumor

Expression of the RAG-2 gene in murine central nervous system tumor cell lines

1991 ◽  
Vol 181 (1) ◽  
pp. 151-158 ◽  
Author(s):  
Kei Tashiro ◽  
Toru Nakano ◽  
Tasuku Honjo ◽  
Tomokazu Aoki ◽  
Shin-ichi Miyatake ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Cell ◽  
Cell Lines ◽  
Central Nervous System Tumor ◽  
Tumor Cell Lines ◽  
System Tumor

scholarly journals Diagnostic accuracy of squash cytology in central nervous system tumors

2017 ◽  
Vol 20 (1) ◽  
pp. 3-9
Author(s):  
Ram Kumar Shrestha ◽  
Bibek KC ◽  
Gopal Sedain ◽  
Gita Sayami ◽  
Sushil Shilpakar ◽  
...  
Keyword(s):  
Decision Making ◽  
Central Nervous System ◽  
Nervous System ◽  
Diagnostic Accuracy ◽  
Histopathological Examination ◽  
Biological Behavior ◽  
Central Nervous System Tumor ◽  
Quick Method ◽  
System Tumor ◽  
Method Of Evaluation

Introduction: CNS tumor requires intraoperative decision making regarding the extent of tumor removal. Clinical examination and imaging studies are not sufficient enough to predict the biological behavior of the tumors. Squash cytology is a quick method of evaluation of cytomorphologic features prepared from smear technique and provide the preliminary diagnosis and aid in intraoperative decision making by differentiating neoplastic from non neoplastic and benign from malignant lesions. The aim of this study is compare the diagnostic accuracy of squash cytology to that of histopathological examination. Methods: This study consists of 36 specimens from both brain and spine subjected to both squash cytology and histopathological evaluation. The squash preparation and histopathological finding were later compared and diagnostic accuracy calculated. Results: Gliomas are the most common tumor encountered and the accuracy of Squash cytology obtained was 71%. In meningioma, 100% diagnostic accuracy was obtained however, there was limitation in accurately predict the subgroup of tumor by squash cytology alone. Other neoplastic lesions included in this study were Schwannoma, Oligodendroglioma, Ependymoma, mixed tumors and others. Overall, the accuracy predicted by squash cytology is found to be 77.8 % in this study. Conclusion: Squash cytology is rapid and reliable method of tissue diagnosis that aid in intraoperative decision making regarding the extent of Central Nervous System tumor excision

scholarly journals QOL-52. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i168-i168
Author(s):  
Kathleen Dorris ◽  
Jessica Channell ◽  
Molly Hemenway ◽  
Angelina Baroffio ◽  
Michael Ellison ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Tumor ◽  
System Tumor

Action observation therapy in pediatric patients with neuromotor deficits of the upper limbs secondary to central nervous system tumors

2019 ◽  
Vol 105 (6) ◽  
pp. NP75-NP78
Author(s):  
Marco Chisari ◽  
Raffaella Sensi ◽  
Carlo Alfredo Clerici ◽  
Fulvia Angela Gariboldi ◽  
Filippo Spreafico ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mirror Neurons ◽  
Action Observation ◽  
Case Series ◽  
Central Nervous System Tumor ◽  
Assessment Tests ◽  
System Tumor ◽  
Positive Results

This study reports a case series of patients with upper limb neuromotor deficits following pediatric central nervous system tumor and treated with rehabilitative therapy according to action observation therapy (AOT). AOT is based on the “mirror neurons” system and had positive results in various non-oncologic neurologic pathologies. This study is the first experience in the oncology field, and included 6 patients, 4 of whom were fully evaluated at 6-month follow-up. In all patients, therapy showed improvement in all assessment tests. These promising results lead to further studies to confirm their effectiveness.

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