scholarly journals Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study

2020 ◽  
Vol Volume 14 ◽  
pp. 869-880
Author(s):  
Dirk Schriefer ◽  
Rocco Haase ◽  
Jennifer S Kullmann ◽  
Tjalf Ziemssen
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Observational Study ◽  
Treatment Satisfaction ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Large Observational Study ◽  
The Relationship

Relating health-related Quality of Life to disability progression in multiple sclerosis, using the 5-level EQ-5D

2013 ◽  
Vol 19 (9) ◽  
pp. 1190-1196 ◽  
Author(s):  
Emer Fogarty ◽  
Cathal Walsh ◽  
Roisin Adams ◽  
Christopher McGuigan ◽  
Michael Barry ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Resource Allocation ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Anxiety Depression ◽  
The Relationship ◽  
Inform Resource Allocation

Background: Increasing use of the Quality-Adjusted Life-Year to inform resource allocation decision-making has highlighted the importance of relating clinical and health-related quality of life (HRQoL) outcomes in multiple sclerosis (MS) patients. Objective and Methods: To investigate the relationship between the Expanded Disability Status Scale (EDSS) and HRQoL utility, using the 5-level EQ-5D (EQ-5D-5L). The discriminatory power of the EQ-5D-5L was assessed using Shannon’s indices. Results: A linear decline in utility was observed with changes in EDSS score from 0 to 6, after which point the relationship exhibited greater variability. Mean utility values ranged from −0.22 at EDSS 9 to 0.88 at EDSS 0. We found that the discriminative capacity of the EQ-5D-5L was considerably lower for the domains self-care and anxiety/depression, compared with other health-related domains. Conclusion: In its first reported use in an MS population, the EQ-5D-5L displayed good discriminatory capacity, although performance differed between the various domains of health, with evidence of a ceiling effect present in the domains of self-care and anxiety/depression. The EQ-5D-5L demonstrated a high correlation with EDSS in our MS cohort up to EDSS 6, after which point the utility valuation of severe health states exhibited much greater variability. Utility estimates from this study may be used in economic evaluations of disease-modifying therapies in MS, to inform resource-allocation decisions.

scholarly journals PND24 BURDEN OF MULTIPLE SCLEROSIS ON HEALTH-RELATED QUALITY OF LIFE: BASELINE FINDINGS FROM AN OBSERVATIONAL STUDY

2009 ◽  
Vol 12 (3) ◽  
pp. A194
Author(s):  
D Jeffery ◽  
S Kirzinger ◽  
J Halper ◽  
R Preblick ◽  
Y Jia Bi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Observational Study ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

2021 ◽  
Vol 47 ◽  
pp. 102620
Author(s):  
Alexander Fidao ◽  
Alysha De Livera ◽  
Nupur Nag ◽  
Sandra Neate ◽  
George A Jelinek ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Relationship

scholarly journals The Relationships between Physical Activity, Self-Efficacy, and Quality of Life in People with Multiple Sclerosis

2019 ◽  
Vol 9 (12) ◽  
pp. 121 ◽  
Author(s):  
Marco Guicciardi ◽  
Maria Carta ◽  
Massimiliano Pau ◽  
Eleonora Cocco
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Multiple Sclerosis ◽  
Goal Setting ◽  
Self Efficacy ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Relationship

Regular physical activity (PA) can enhance the physical and mental health of people with Multiple Sclerosis (MS) because of its impact on muscular strength, mobility, balance, walking, fatigue, pain and health-related quality of life (HRQoL). Previous studies have hypothesized that the relationship between PA and HRQoL is mediated by self-efficacy. The aim of this research is to evaluate whether self-efficacy in goal setting and self-efficacy in the management of symptoms, mediate the relationship between PA and HRQoL, in a similar way to exercise self-efficacy. A sample of 28 participants with MS (18 females) and different levels of physical activity have been recruited and completed the following measures: (a) physical activity (GLTEQ); (b) health-related quality of life (SF-12); (c) self-efficacy in the management of Multiple Sclerosis (SEMS) and, (d) exercise self-efficacy (EXSE). The statistical analysis highlighted that self-efficacy in goal setting mediated the relationship between PA and mental health better than exercise self-efficacy. Our findings suggest that self-efficacy in goal setting can contribute to the adoption and maintenance of regular physical activity for long-lasting times, supporting and increasing the mental quality of life of people suffering from MS.

1020-P: Semaglutide-Induced Weight Loss Is Associated with Improved Health-Related Quality of Life and Treatment Satisfaction

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1020-P ◽  
Author(s):  
KARI T. UUSINARKAUS ◽  
HELENA W. RODBARD ◽  
LUC VAN GAAL ◽  
JOHN P. WILDING ◽  
THOMAS HANSEN ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Treatment Satisfaction ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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