Expression of MicroRNA-1281, C-Reactive Protein, and Renal Function in Individuals with Abdominal Aortic Aneurysm and their Clinical Correlation after Endovascular Repair

Aim: The aim of this study was to compare midterm mortality between anemic and nonanemic patients undergoing endovascular repair of abdominal aortic aneurysm and to assess a correlation with markers of inflammation. Methods: Anemia was defined as hemoglobin <13 (men) and <12 g/dL (women). The impact of anemia and inflammatory markers on mortality was assessed using Kaplan-Meier curves and Cox regression. Results: A total of 224 patients (12 females [5.36%]; age: 69.73 ± 8.72 years) were included; 102 (45.53%) were anemic. Median follow-up was 17 months (interquartile range: 7-25 months). Nine patients died (1.79%; 8 anemic vs 1 nonanemic). Survival was lower for patients with anemia (log-rank, P = .01). White blood cell count and C-reactive protein (CRP) differed significantly ( P < .001 and P = .01). Anemia and CRP were associated with decreased survival (Cox regression, P = .01, hazard ratio [HR]: 0.35, 95% confidence interval: 0.14-0.84 and P = .002, HR: 1.18, 95% CI: 1.06-1.31). Conclusion: Patients with anemia had decreased survival over the midterm; inflammatory markers were higher among this group.

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Serum C-Reactive Protein Level Is Associated With Abdominal Aortic Aneurysm Size and May Be Produced by Aneurysmal Tissue

Circulation ◽

10.1161/01.cir.0000059938.95404.92 ◽

2003 ◽

Vol 107 (8) ◽

pp. 1103-1105 ◽

Cited By ~ 134

Author(s):

Tryfon Vainas ◽

Tim Lubbers ◽

Frank R.M. Stassen ◽

Selma B. Herngreen ◽

Marja P. van Dieijen-Visser ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Protein Level ◽

C Reactive Protein ◽

Reactive Protein ◽

Aneurysm Size ◽

Abdominal Aortic

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Association of high sensitivity C-reactive protein and abdominal aortic aneurysm: a meta-analysis and systematic review

Current Medical Research and Opinion ◽

10.1080/03007995.2017.1354825 ◽

2017 ◽

Vol 33 (12) ◽

pp. 2145-2152 ◽

Cited By ~ 5

Author(s):

Yunpeng Wang ◽

Guanghui Shen ◽

Haiyang Wang ◽

Ye Yao ◽

Qingfeng Sun ◽

...

Keyword(s):

Systematic Review ◽

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Meta Analysis ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic

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The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation

Angiology ◽

10.1177/0003319709335027 ◽

2009 ◽

Vol 60 (5) ◽

pp. 576-581 ◽

Cited By ~ 4

Author(s):

Stephen A. Badger ◽

Chee V. Soong ◽

Ian S. Young ◽

Ann McGinty ◽

Caroline Mercer ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Serum Concentration ◽

High Sensitivity ◽

Nucleotide Polymorphisms ◽

C Reactive Protein ◽

Single Nucleotide ◽

Reactive Protein ◽

Abdominal Aortic ◽

Cox 2

Introduction Cyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations. Patients and Methods Patients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed. Results A total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 ( P = .26) and rs4648307 ( P = .90). They did not influence the hsCRP concentration ( P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference. Conclusion These COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.

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