Plasma C-Reactive Protein and Abdominal Aortic Aneurysm

Introduction Cyclooxygenase (COX)-2 influences cardiovascular disease and serum concentration of high-sensitivity C-reactive protein (hsCRP). The study purpose was to determine the influence of single nucleotide polymorphisms (SNPs) of the COX-2 gene on abdominal aortic aneurysm (AAA) development and serum hsCRP concentrations. Patients and Methods Patients with AAA and disease-free controls were recruited. High-sensitivity C-reactive protein was measured by an enzyme-linked immunosorbent assay (ELISA) test. The distributions of COX-2 SNPs were investigated (rs20417 and rs4648307). The influence of the COX-2 SNPs on the hsCRP serum concentration was assessed. Results A total of 230 patients with AAA and 279 controls were included. No difference was found in the genotype distribution of the COX-2 SNPs rs20417 ( P = .26) and rs4648307 ( P = .90). They did not influence the hsCRP concentration ( P = .24 and P = .61, respectively). Haplotype analysis of COX-2 SNPs revealed no difference. Conclusion These COX-2 SNPs do not play any role in AAA development and do not influence serum hsCRP. These results differentiate AAA development from atherosclerotic diseases.

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C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism

Journal of Vascular Surgery ◽

10.1016/j.jvs.2008.07.081 ◽

2009 ◽

Vol 49 (1) ◽

pp. 178-184 ◽

Cited By ~ 21

Author(s):

Stephen A. Badger ◽

Chee V. Soong ◽

Mark E. O' Donnell ◽

Caroline Mercer ◽

Ian S. Young ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Genetic Polymorphism ◽

Aortic Aneurysm ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic

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Prediction of abdominal aortic aneurysm calcification by means of variation of high-sensitivity C-reactive protein

JRSM Cardiovascular Disease ◽

10.1177/2048004016682177 ◽

2016 ◽

Vol 5 ◽

pp. 204800401668217 ◽

Cited By ~ 2

Author(s):

Emirena Garrafa ◽

Alessio Giacomelli ◽

Marco Ravanelli ◽

Patrizia Dell’Era ◽

Michele Peroni ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic

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Prediction of asymptomatic abdominal aortic aneurysm expansion by means of rate of variation of C-reactive protein plasma levels

Journal of Vascular Surgery ◽

10.1016/j.jvs.2012.01.003 ◽

2012 ◽

Vol 56 (1) ◽

pp. 45-52 ◽

Cited By ~ 33

Author(s):

Joaquin De Haro ◽

Francisco Acin ◽

Silvia Bleda ◽

Cesar Varela ◽

Francisco J. Medina ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Plasma Levels ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic

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Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

Atherosclerosis ◽

10.1016/j.atherosclerosis.2009.09.027 ◽

2010 ◽

Vol 209 (2) ◽

pp. 487-491 ◽

Cited By ~ 18

Author(s):

Jonathan Golledge ◽

Erik Biros ◽

Matthew Cooper ◽

Nicole Warrington ◽

Lyle J. Palmer ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Apolipoprotein E ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic ◽

Apolipoprotein E Genotype

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Acute Pyelonephritis Associated with Ruptured Abdominal Aortic Aneurysm: An Unusual Presentation

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001510 ◽

2020 ◽

Author(s):

Rafael Ferreira Nascimento ◽

Carolina Morna ◽

Mariana Bilreiro ◽

Ines Correia

Keyword(s):

Computed Tomography ◽

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Acute Pyelonephritis ◽

Ruptured Abdominal Aortic Aneurysm ◽

Computed Tomography Scan ◽

C Reactive Protein ◽

Reactive Protein ◽

Abdominal Aortic ◽

Tomography Scan

We describe a rare presentation of acute pyelonephritis associated with a ruptured abdominal aortic aneurysm. A 68-year-old female presented to the emergency department with a 3 day history of cystitis. General examination revealed the acute onset of pain in the left flank accompanied by fever and chills. Blood tests revealed leucocytosis 25,400x109L and C-reactive protein 495 mg/L (<6.1), while urinary sediment analysis revealed many leucocytes and gram-negative bacteria. The patient was admitted with acute pyelonephritis. On the third day of admission, the urine culture isolated Escherichia coli sensitive to the antibiotic prescribed; however, the patient clinically deteriorated. A computed tomography scan revealed a ruptured abdominal aortic aneurysm involving the left renal artery. The patient underwent an exploratory laparotomy but uncontrollable haemorrhage led to a fatal outcome. This case highlights a rare case of acute pyelonephritis associated with a ruptured abdominal aortic aneurysm. A computed tomography scan or abdominal ultrasound should be considered whenever a patient has acute pyelonephritis with a C-reactive protein >400 mg/L in order to exclude complications and other potentially fatal pathologies.

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