ANOSMIA IN COVID-19 INFECTION - A CASE SERIES

Background:The aim of this study is to highlight anosmia as an important symptom to predict SARS-CoV-2 infection. The presentation of the disease commonly includes fever, cough, weakness, myalgia and breathlessness making anosmia a rare symptom. Methods:We included a total of 10 patients in the study who were between the age group of 18-70 years with the complaints of anosmia. Results:8 out of the 10 patients had come with fever and cough initially and developed anosmia later. However, 2 patients had presented to us with anosmia alone as the first symptom and then on further evaluation were found to be COVID-19 positive. The available clinical data was collected, recorded and the results were analyzed. Conclusion:Anosmia is a rare or late, but contributory symptom of the coronavirus disease. Thus, clinicians should keep in mind the diagnosis of COVID-19 while treating patients presenting with such atypical symptoms for early detection & in-time treatment of COVID 19 infection to prevent complications associated with the disease.

Download Full-text

Morquio A syndrome and effect of enzyme replacement therapy in different age groups of Turkish patients: a case series

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-021-01761-0 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Sebile Kılavuz ◽

Sibel Basaran ◽

Deniz Kor ◽

Fatma Derya Bulut ◽

Sevcan Erdem ◽

...

Keyword(s):

Enzyme Replacement Therapy ◽

Replacement Therapy ◽

Clinical Data ◽

Treatment Initiation ◽

Case Series ◽

Enzyme Replacement ◽

Morquio A ◽

Over Time ◽

Morquio A Syndrome

Abstract Background This case series includes longitudinal clinical data of ten patients with Morquio A syndrome from south and southeastern parts of Turkey, which were retrospectively collected from medical records. All patients received enzyme replacement therapy (ERT). Clinical data collected included physical appearance, anthropometric data, neurological and psychological examinations, cardiovascular evaluation, pulmonary function tests, eye and ear-nose-throat examinations, endurance in the 6-min walk test and/or 3-min stair climb test, joint range of motion, and skeletal investigations (X-rays, bone mineral density). Results At the time of ERT initiation, two patients were infants (1.8 and 2.1 years), five were children (3.4–7.1 years), and three were adults (16.5–39.5 years). Patients had up to 4 years follow-up. Most patients had classical Morquio A, based on genotypic and phenotypic data. Endurance was considerably reduced in all patients, but remained relatively stable or increased over time in most cases after treatment initiation. Length/height fell below normal growth curves, except in the two infants who started ERT at ≤ 2.1 years of age. All patients had skeletal and/or joint abnormalities when ERT was started. Follow-up data did not suggest improvements in skeletal abnormalities, except in one of the younger infants. Nine patients had corneal clouding, which resolved after treatment initiation in the two infants, but not in the other patients. Hepatomegaly was reported in seven patients and resolved with treatment in five of them. Other frequent findings at treatment initiation were coarse facial features (N = 9), hearing loss (N = 6), and cardiac abnormalities (N = 6). Cardiac disease deteriorated over time in three patients, but did not progress in the others. Conclusions Overall, this case series with Morquio A patients confirms clinical trial data showing long-term stabilization of endurance after treatment initiation across ages and suggest that very early initiation of ERT optimizes growth outcomes.

Download Full-text

Maternal outcome in obstructed labour in patients presenting to Nishtar Hospital Multan.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.03.4304 ◽

2021 ◽

Vol 28 (03) ◽

pp. 377-381

Author(s):

Sadia Zafar ◽

Nadia Taj ◽

Rida Iqbal ◽

Muhammad Sajjad Masood

Keyword(s):

Vesicovaginal Fistula ◽

Postpartum Haemorrhage ◽

Case Series ◽

Maternal Outcome ◽

Bladder Rupture ◽

Age Group ◽

Maternal Deaths ◽

Obstructed Labour ◽

Maternal Morbidity And Mortality ◽

Labour Ward

Objective: The objective of the study was to determine the frequency of maternal outcome in obstructed labour. Study Design: Descriptive Case Series. Setting: Labour Ward of Nishtar Hospital Multan, Pakistan. Period: 01-11-2018 to 30-04-2019. Material & Methods: Two hundred and forty two clinically diagnosed cases of obstructed labour admitted in labour ward of Nishtar Hospital Multan were enrolled for the study. Patients were monitored till delivery (vaginal/caesarean section) and complication of pregnancy were assessed till six week postpartum. Outcome variables i.e. complications like sepsis, uterine rupture, bladder rupture, vesicovaginal fistula, postpartum haemorrhage, and mortality was noted. Data was analyzed by using SPSS version 10.0. Results: The majority of women was in age group 20-29 years i.e. 42.97% and were primigravida. Sepsis was the most frequent maternal complication observed i.e. in 22.31% of cases. Postpartum haemorrhage was next in line i.e. in 19.42% of cases. Uterine and bladder rupture was a finding in 16.94% and 7.02% of cases respectively. Vesicovaginal fistula was recorded in 12 (4.95%) patients and there were 1 (4.54%) maternal deaths during the study period. Conclusion: Obstructed labour is an important and preventable cause of both maternal morbidity and mortality and needs to be addressed adequately with provision of better antenatal, intrapartum, and postnatal care.

Download Full-text

Functional outcome of diaphyseal fractures of forearm in adolescents treated with TENS

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20190642 ◽

2019 ◽

Vol 5 (3) ◽

pp. 69

Author(s):

Divyanshu Goyal ◽

S. L. Sharma ◽

Laxmikant Meena ◽

Ravindra Lamoria ◽

Mahesh Bansal

Keyword(s):

Range Of Motion ◽

Functional Outcome ◽

Case Series ◽

Age Group ◽

Forearm Fractures ◽

Retrospective Case ◽

Superficial Infection ◽

Fractures In Children ◽

Case Series Study ◽

Diaphyseal Fractures

Background: A retrospective case series study was done on forearm diaphyseal fracture in adolescents treated with TENS (titanium elastic nailing system). Purpose of the study was analysis of functional outcome of TENS in forearm diaphyseal fractures in children between 12-18 year age group.Methods: We retrospectively evaluated 30 patients operated by same senior surgeon during the period from March 2014 to February 2015 with closed diaphyseal forearm fractures in age group 12–18 years treated with TENS in whom closed reduction could not be achieved. Nail diameter taken as 33-40% of narrowest diameter of diaphysys were introduced proximally in ulna and distally in radius under image intensifier in closed manner. Postoperatively, patients encouraged for active shoulder, elbow and finger movements and suture removal done after 2 weeks. Patients were followed up for minimum period of one year. Results: In terms of union and range of motion using Anderson et al criteria 24 patients had excellent results, 4 patients had satisfactory results and one patient had poor result having non-union of ulna. Two patients had superficial infection at the nail entry site which eventually resolved. One patient lost for follow up.Conclusions: We conclude that TENS in both bone forearm fractures in adolescent age group in terms of union and range of motion is a minimally invasive and effective method of fixation.

Download Full-text

Femoral malalignment after gamma nail insertion in the lateral decubitus position

SICOT-J ◽

10.1051/sicotj/2018033 ◽

2018 ◽

Vol 4 ◽

pp. 34

Author(s):

Hossam M.A. Abubeih ◽

Osama Farouk ◽

Mohammad Kamal Abdelnasser ◽

Amr Atef Eisa ◽

Galal Zaki Said ◽

...

Keyword(s):

Case Series ◽

Gamma Nail ◽

Lateral Decubitus Position ◽

Entry Point ◽

Age Group ◽

Rotational Malalignment ◽

Implant Positioning ◽

High Incidence ◽

Nail Insertion ◽

Lateral Decubitus

Introduction: Insertion of gamma nail with the patient in lateral decubitus position have the advantages of easier access to the entry point, easier fracture reduction and easier implant positioning. Our study described the incidence of femoral angular and rotational deformity following gamma nail insertion in lateral decubitus position. Methods: In a prospective clinical case series, 31 patients (26 males and 5 females; the average age of 42.6 years) with 31 proximal femoral shaft fractures that were treated with gamma IMN were included in our study. Postoperatively, computerized tomography scans of the pelvis and both knees (injured and uninjured sides) were examined to measure anteversion angles on both sides. A scout film of the pelvis and upper both femurs was taken to compare the neck shaft angles on both sides. Results: No angular malalignment was detected in our series; the mean angular malalignment angle was 1.6 ± 1.5°. There was a high incidence of true rotational malalignment of ≥10° in 16 out of 31 patients (51.6%); most of them were external rotational malalignment. Younger age group (≤40 years) had significantly more incidence of rotational malalignment (≥10°) than older age group (>40 years) (P-value 0.019). Discussion: Gamma nail fixation in lateral decubitus position without the fracture table gives an accurate and easier access to the entry point, good implant positioning with no or minimal angular malalignment (varus −valgus) but poses high incidence of true rotational malalignment. Great care and awareness of rotation should be exercised during fixing proximal femoral fractures in lateral decubitus position.

Download Full-text

Early detection of Parkinson's disease using data mining techniques from multimodal clinical data

Advanced Machine Vision Paradigms for Medical Image Analysis ◽

10.1016/b978-0-12-819295-5.00008-1 ◽

2021 ◽

pp. 213-228

Author(s):

Sneham Priya ◽

R. Priyatharshini ◽

Rudraraju Shruthi ◽

V. Pooja ◽

R. Sai Swarna

Keyword(s):

Data Mining ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Early Detection ◽

Clinical Data ◽

Data Mining Techniques ◽

Using Data

Download Full-text

Study on MRI Spectrum of ACL Tears in Pediatric Age Group: A Case Series

10.9734/bpi/nfmmr/v15/13029d ◽

2021 ◽

pp. 100-111

Author(s):

Shashi Sharma ◽

Bharat Bhushan Sharma ◽

Naresh Chander Arora ◽

Manav Sethi ◽

Neeru Kapur ◽

...

Keyword(s):

Case Series ◽

Age Group ◽

Pediatric Age ◽

Pediatric Age Group ◽

Group A

Download Full-text

Scaphoid Fractures below the Age of 10: Case Series and Review of the Literature

Journal of Wrist Surgery ◽

10.1055/s-0040-1713800 ◽

2020 ◽

Vol 9 (06) ◽

pp. 458-464

Author(s):

Rachana Tataria ◽

Jeannette Ting ◽

Andrea Jester ◽

Tommy R. Lindau ◽

Kerstin Oestreich

Keyword(s):

Pediatric Population ◽

Age Groups ◽

Case Series ◽

Final Diagnosis ◽

Scaphoid Bone ◽

Age Group ◽

Level Of Evidence ◽

Scaphoid Fractures ◽

Fractures In Children ◽

Common Location

Abstract Background Scaphoid fractures are relatively uncommon in children, especially below the age of 10 due to the ossification of the scaphoid bone, which starts around 4 to 6 years of age and continues until 13 to 15 years of age, where pediatric scaphoid fractures peak. This makes the diagnoses challenging in this age group. Methods The primary aim of this study was to analyze prospectively collected data in managing scaphoid fractures. All cases in children up to the age of 10 years, treated in a tertiary pediatric hand and upper limb from January 2014 to June 2018 were included. Parameters studied were patient demographics, clinical presentation, mechanism of injury, investigations, type of fracture, associated injuries, treatment offered, outcomes and complications. The secondary aim was to review the literature due to the limited knowledge about these fractures in these low age groups. Results A total of 23 patients with documented scaphoid fractures in children up to the age of 10 years were found. Final diagnosis in all these patients was done with magnetic resonance imaging (MRI). The mean age was 9.8 years, with female preponderance. Scaphoid waist was the most common location. Five patients had associated fractures of the capitate and one patient had associated second metacarpal base fracture. All patients were managed nonoperatively. The average time of immobilization was 6.6 weeks (range: 4–10 weeks). A majority of patients had minor symptoms after the fracture, most likely due to the immobilization time. Conclusion Scaphoid fractures are rare in the pediatric population up to the age of 10. MRI is most often needed to confirm diagnosis. Nonoperative management of most scaphoid fractures in this age group is safe and feasible with no significant long-term morbidity. Surgical management of scaphoid fractures might be required in very selected cases. Level of Evidence This is a Level IV study.

Download Full-text

Prevalence of Autism Spectrum Disorder among Rural, Urban, and Tribal Children (1–10 Years of Age)

Journal of Neurosciences in Rural Practice ◽

10.4103/jnrp.jnrp_329_16 ◽

2017 ◽

Vol 08 (03) ◽

pp. 368-374 ◽

Cited By ~ 13

Author(s):

Sunil Kumar Raina ◽

Vishav Chander ◽

Ashok K. Bhardwaj ◽

Dinesh Kumar ◽

Seema Sharma ◽

...

Keyword(s):

Case Reports ◽

Case Series ◽

Autism Spectrum ◽

Second Phase ◽

Age Group ◽

Socioeconomic Group ◽

Cross Sectional ◽

Geographical Regions ◽

Evaluation Phase ◽

Tribal Populations

ABSTRACT Introduction: Studies on autism spectrum disorders (ASDs) have largely focused on children in specific settings. The current scenario of research in ASDs is limited largely to clinic-based case reports, case series, and retrospective chart reviews. The present study is the first population-based prevalence study conducted across rural, urban, and tribal populations in India. Materials and Methods: A cross-sectional two-phase study was conducted cring children in the age group of 1–10 years of age across geographical regions representing rural, urban, and tribal populations. The first phase (screening phase) involved administration of the Hindi version of the Indian Scale for Assessment of Autism. Those identified as suspected of ASD and 10% of all classified as nonsuspects for autism were also evaluated by the clinical team in second phase (evaluation phase). Results: Forty-three children out of a total of 28,070 children in rural, urban, and tribal area in the age group of 1–10 years were diagnosed as cases of ASD yielding a prevalence of 0.15% (95% confidence interval [CI] =0.15–0.25). Logistic regression analysis showed a two times significantly higher risk of diagnosing ASD in rural area as compared to tribal (odds ratio [OR]; 95% CI = 2.17 [1.04–4.52], P = 0.04). Male sex and upper socioeconomic group of head of family/father had a higher risk of getting diagnosed as autism as compared to lower socioeconomic group (OR; 95% CI - 3.23; 0.24–44.28, P = 0.38). Conclusions: Estimation of true prevalence of ASD in India is going to improve policies on developmental disabilities.

Download Full-text

Neonatal ventriculitis: a case series and review of literature

Tropical Doctor ◽

10.1177/0049475520927626 ◽

2020 ◽

Vol 50 (3) ◽

pp. 266-270

Author(s):

Ramitha R Bhat ◽

Prerna Batra ◽

Ravi Sachan ◽

Gurbachan Singh

Keyword(s):

Intracranial Pressure ◽

External Ventricular Drain ◽

Fatal Outcome ◽

Case Series ◽

Age Group ◽

Raised Intracranial Pressure ◽

Review Of Literature ◽

Intravenous Antibiotic ◽

Intravenous Antibiotics

Ventriculitis after meningitis is a serious complication in the neonatal age group. The role of intraventricular antibiotics in treatment is controversial. We present five such cases which were refractory to conventional intravenous antibiotic therapy, had persistent features of ventriculitis and in whom raised intracranial pressure (ICP) necessitated insertion of an external ventricular drain (EVD). Three of the five infants required intraventricular antibiotics but also developed EVD-related complications. Early diagnosis of ventriculitis and treatment is necessary to avoid a fatal outcome. Intravenous antibiotics are the treatment of choice, but intraventricular therapy may be considered in refractory cases. As the incidence of EVD-associated ventriculitis is high, proper care of EVDs and their early removal is mandatory.

Download Full-text