scholarly journals Probiotic Lactobacillus reuteri DSM 17938: what is known about it today?

2019 ◽  
pp. 236-242
Author(s):  
I. N. Zakharova ◽  
I. V. Berezhnaya ◽  
A. Е. Kuchina ◽  
O. V. Dedikova
Keyword(s):  
Intestinal Microbiota ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Pathogenic Microorganisms ◽  
Infantile Colic ◽  
Regulatory T Lymphocytes ◽  
Probiotic Lactobacillus ◽  
Infant Colic ◽  
Inflammatory Bowel ◽  
Pro Inflammatory Cytokines

The review is devoted to the analysis of data on the effects of Lactobacillus reuteri DSM 17938, confirmed in clinical trials. Thanks to their antimicrobial activity, L. reuteri is able to inhibit colonization by pathogenic microorganisms and restore the composition of compensatory intestinal microbiota. Another study showed a positive protective effect of intestinal microbiota when administered L. reuteri simultaneously with antibiotics. In addition, L. reuteri supports the immune system of the human body. For example, some strains of L. reuteri may reduce the production of pro-inflammatory cytokines while stimulating the development and proliferation of regulatory T-lymphocytes. Adding L. reuteri to the diet may be attractive in terms of preventing the development of inflammatory bowel disease. The results of a recent meta-analysis confirmed the efficacy of L. reuteri in the treatment of infantile colic. Further research is aimed at finding evidence of the efficacy of L. reuteri use in children who are artificially fed, with infant colic and in children born by caesarean section.

scholarly journals Lactobacillus Reuteri DSM 17938 in Infantile Colic: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 6 (3) ◽  
pp. 1446-1454
Author(s):  
Burhannudin Ichsan ◽  
Nining Lestari ◽  
Sulistyani
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Forest Plot ◽  
Infantile Colic ◽  
Eligibility Criteria ◽  
Randomized Controlled ◽  
Infant Colic ◽  
Systematic Synthesis

Background. Infantile colic, defined as paroxysmal, excessive, and consolable crying without an identifiable cause. It is common in the first 3 months of life. There have been many RCT studies conducted. A systematic synthesis is required to summarize the results of these RCTs. This study was aimed to systematically analyze the benefits of Lactobacillus reuteri DSM 17938 for infantile colic. Methods. This systematic review and meta-analysis used keywords: (“infantile colic” OR “abdominal cramps” OR “abdominal cramp” OR “infant colic”) AND “lactobacillus reuteri” AND (placebo OR placebos) AND (“randomized controlled trial” OR RCT). The databases used were: pubmed, science direct, and google scholar. Meta-analysis was conducted to combine the articles. The eligibility criteria were: patient with infantile colic, intervention with L. reuteri DSM 17938, control was placebo, RCT study design, outcome with dichotomous scale, all races, all ethnicities, all countries, all genders, in English, and not limited by year. Results. The search resulted in 800 articles. After reducing duplication, the number of articles was 747. Screening with titles and abstracts resulted in 13 full teks articles. Six articles fitted the eligibility criteria. The results of the meta-analysis were as follows. The forest plot showed that the combined effect of the six articles showed an RR of 0.47 and was statistically significant (p <0.001). Conclusion. Based on the results of this meta-analysis, L. reuteri DSM 17938 is recommended for infants with infantile colic. There were no significant side effects with the use of L. reuteri DSM 17938 on infantile colic.

Probiotics for the Treatment of Infantile Colic: A Systematic Review

2016 ◽  
Vol 30 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Anna Schreck Bird ◽  
Philip J. Gregory ◽  
Mohamed A. Jalloh ◽  
Zara Risoldi Cochrane ◽  
Darren J. Hein
Keyword(s):  
Systematic Review ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Infantile Colic ◽  
Probiotic Supplementation ◽  
Breastfed Infants ◽  
Healthy Infants ◽  
Potential Strategy ◽  
Different Strains ◽  
Specific Species

Objective: To evaluate whether clinical data support the safety and efficacy of probiotics for the management of infantile colic. Background: Probiotics have been suggested as a potential strategy for infantile colic, and the specific species that have been studied in healthy infants are considered to be safe. Methodology: A systematic review was conducted to identify randomized controlled trials (RCTs) evaluating the use of probiotic supplementation in infants with colic. RCTs with a primary end point assessing crying or fussing time were selected. A meta-analysis comparing “responders” to “nonresponders” in infants receiving probiotic versus control was conducted. The quality of trials selected was assessed. Results: Five RCTs assessing 2 different strains of the probiotic Lactobacillus reuteri in mostly breastfed infants were identified. Analysis of response rates showed that infants receiving probiotics had a 2.3-fold greater chance of having a 50% or greater decrease in crying/fussing time compared to controls ( P = .01). Probiotic supplementation was not associated with any adverse events. Conclusion: Supplementation with the probiotic L. reuteri in breastfed infants appears to be safe and effective for the management of infantile colic. Further research is needed to determine the role of probiotics in infants who are formula-fed.

scholarly journals Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial

BMJ ◽  
2014 ◽  
Vol 348 (apr01 2) ◽  
pp. g2107-g2107 ◽  
Author(s):  
V. Sung ◽  
H. Hiscock ◽  
M. L. K. Tang ◽  
F. K. Mensah ◽  
M. L. Nation ◽  
...  
Keyword(s):  
Lactobacillus Reuteri ◽  
Randomised Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Probiotic Lactobacillus ◽  
Infant Colic

scholarly journals The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials

2020 ◽  
Vol 9 (4) ◽  
pp. 999 ◽  
Author(s):  
Karolina Skonieczna-Żydecka ◽  
Katarzyna Janda ◽  
Mariusz Kaczmarczyk ◽  
Wojciech Marlicz ◽  
Igor Łoniewski ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lactobacillus Reuteri ◽  
Meta Analysis ◽  
Intervention Group ◽  
Intestinal Microbiome ◽  
Infantile Colic ◽  
Breastfed Infants ◽  
Mean Differences ◽  
Meta Analyses ◽  
The Impact

Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. Lactobacillus reuteri strain DSM17938 was administered predominantly (n = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, p < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, p < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed.

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