Can the Probiotic Lactobacillus reuteri Be Used to Treat Infant Colic?

The review is devoted to the analysis of data on the effects of Lactobacillus reuteri DSM 17938, confirmed in clinical trials. Thanks to their antimicrobial activity, L. reuteri is able to inhibit colonization by pathogenic microorganisms and restore the composition of compensatory intestinal microbiota. Another study showed a positive protective effect of intestinal microbiota when administered L. reuteri simultaneously with antibiotics. In addition, L. reuteri supports the immune system of the human body. For example, some strains of L. reuteri may reduce the production of pro-inflammatory cytokines while stimulating the development and proliferation of regulatory T-lymphocytes. Adding L. reuteri to the diet may be attractive in terms of preventing the development of inflammatory bowel disease. The results of a recent meta-analysis confirmed the efficacy of L. reuteri in the treatment of infantile colic. Further research is aimed at finding evidence of the efficacy of L. reuteri use in children who are artificially fed, with infant colic and in children born by caesarean section.

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Colic in infants: modern approaches to patient management

Лечащий врач ◽

10.51793/os.2021.24.6.004 ◽

2021 ◽

Author(s):

С.Б. Крутихина ◽

Е.А. Яблокова ◽

М.А. Кудряшова ◽

Е.В. Борисова ◽

Е.Ю. Полотнянко

Keyword(s):

Quality Of Life ◽

Patient Management ◽

Lactobacillus Reuteri ◽

Family Stress ◽

Prone Positioning ◽

Functional Disorders ◽

Infant Colic ◽

Rome Iv ◽

Infants And Young Children

Функциональные расстройства желудочно-кишечного тракта у младенцев и детей раннего возраста являются крайне распространенной проблемой, диагностика которых опирается на Римские критерии IV (четвертого пересмотра). Колики у младенца определенно повышают уровень стресса в семье, ухудшая качество жизни как родителей, так и ребенка. Под младенческими коликами понимаются повторяющиеся длительные периоды плача, беспокойство или раздражительность у младенцев до 5 месяцев. Патофизиология младенческих колик не полностью ясна. Для многих педиатров наблюдение за младенцами с коликами представляет проблему. Среди немедикаментозных техник можно использовать пеленание, убаюкивание с помощью шипящих звуков («ч-ш-ш-ш-ш…»), выкладывание ребенка на живот, укачивание, использование соски, а также применение газоотводной трубочки. В настоящее время активно исследуются возможности применения пробиотиков, например, Lactobacillus reuteri. Functional disorders of the gastrointestinal tract in infants and young children are an extremely common problem, the diagnosis of which is based on the Rome IV criteria. Colic in an infant definitely increases family stress levels, impairing the quality of life for both the parent and the child. Infant colic refers to repeated, prolonged periods of crying, restlessness, or irritability in infants under 5 months of age. The pathophysiology of infant colic is not entirely clear. For many pediatricians, monitoring babies with colic is a challenge. Non-drug techniques include swaddling, prone positioning, rocking, as well as a gas tube. The possibilities of using probiotics, for example, Lactobacillus reuteri, are currently being actively explored.

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An integrated proteomic and physiological approach to understand the adhesion mechanism of the probiotic Lactobacillus reuteri Lb2 BM DSM 16143

Journal of Integrated OMICS ◽

10.5584/jiomics.v3i2.143 ◽

2013 ◽

Vol 3 (2) ◽

Author(s):

Enrica Pessione ◽

Erika Mangiapane ◽

Cristina Lamberti ◽

Alessandro Pessione ◽

Patrizia Ceruti ◽

...

Keyword(s):

Lactobacillus Reuteri ◽

Adhesion Mechanism ◽

Probiotic Lactobacillus ◽

Physiological Approach

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Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women

Nutrients ◽

10.3390/nu12020368 ◽

2020 ◽

Vol 12 (2) ◽

pp. 368 ◽

Cited By ~ 6

Author(s):

Siwen Yang ◽

Gregor Reid ◽

John R.G. Challis ◽

Gregory B. Gloor ◽

Elizabeth Asztalos ◽

...

Keyword(s):

Pregnant Women ◽

Lactobacillus Reuteri ◽

Bacterial Species ◽

Lactobacillus Rhamnosus ◽

Vaginal Microbiota ◽

Low Risk ◽

Fermented Foods ◽

Nugent Score ◽

Cytokines And Chemokines ◽

Probiotic Lactobacillus

Spontaneous preterm birth is associated with vaginal microbial dysbiosis. As certain strains of lactobacilli help restore homeostasis in non-pregnant women, the goal was to determine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 administered orally, twice daily for 12 weeks on the vaginal microbiota, cytokines and chemokines of low-risk pregnant women. A double-blind, placebo-controlled, randomized trial comparing probiotic lactobacilli to placebo daily was performed in 86 asymptomatic pregnant women who had an Intermediate or Bacterial Vaginosis Nugent score at 13 weeks. After drop outs, 32 women receiving probiotics and 34 receiving placebo completed the study. The Nugent score returned to normal in 30% of the women in both groups at 28 weeks and was maintained until 35 weeks. The majority of subjects had normal pregnancy outcomes. Ninety-three bacterial species were detected at 13 weeks, with Lactobacillus iners, Lactobacillus crispatus, Gardnerella vaginalis and Atopobium vaginae being the most abundant across pregnancy. There was no difference in the Shannon diversity index between the probiotic and placebo groups at 13, 28 or 35 weeks. Almost all subjects consumed fermented foods and many of the organisms in the vagina are also known to be present in fermented foods. Interleukin-4 in the placebo group and Interleukin-10 in both probiotic and placebo groups increased slightly at 28 weeks but were not different at 35 weeks when compared to 13 weeks. In conclusion, this study showed no adverse issues resulting from 12 week use of probiotic Lactobacillus strains GR-1 and RC-14 during pregnancy in women at low risk for premature birth. The vaginal microbiota demonstrated flux irrespective of this oral probiotic administration.

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