scholarly journals Role of anti-inflammatory drugs in the complex therapy of patients with carpal tunnel syndrome

2021 ◽  
pp. 119-124
Author(s):  
S. A. Zhivolupov ◽  
I. N. Samartsev ◽  
R. Z. Nazhmudinov ◽  
M. N. Vorobieva ◽  
A. I. Vlasenko

Introduction. Carpal tunnel syndrome (CTS) is a neurological disease associated with tunnel mononeuropathies. There are various proven treatment regimens for patients with the use of conservative and surgical methods of treatment. Studies devoted to a comparative analysis of the effectiveness of methods of conservative therapy in patients with CTS are not enough to choose a treatment strategy.Purpose of the study. To study the therapeutic efficacy of wearing a wrist orthosis with and without the use of NSAIDs in the treatment of patients with CTS.Materials and methods. The study involved 40 patients (the average age of the participants was 32.8 ± 4.3 years) with a primary diagnosis of CTS, who were admitted to the neurological department of of the St Petersburg State Budgetary Healthcare Institution “Elizavetinskaya Hospital”, the Department of Medical Rehabilitation of St. Petersburg State Budgetary Healthcare Institution “St. Luke’s Clinical Hospital” in the period from 2017 to 2021. Patients were randomized into two comparable groups for complex conservative treatment and observation for 2 months of the dynamics of neurological symptoms, pain scale, QuickDASH questionnaire and neurophysiological parameters. The first group of patients received NSAIDs (Nimesil), 1 sachet (100 mg of nimesulide) twice a day after meals for 4 weeks, and the second group – NSAIDs with the imposition of a wrist orthosis for 4 weeks.Results. The study involved 40 patients. The average age of the participants was 32.8 ± 4.3 years (range from 20 to 48 years). Neurophysiological indicators in the studied groups at the screening stage were comparable: distal latency of the M-response (DLMO), ms; the amplitude of the negative peak of the M-response, mV; sensory latency (SL), ms and sensory impulse conduction velocity (SSPI), m / s: 5.7, 5.3, 3.5 and 31.8 in the first group and 5.4, 5.5, 3.8 and 32.4 in the second group (p > 0.05 when comparing the corresponding parameters). After the course of treatment, significant changes in the analyzed parameters were revealed (p < 0.05).Conclusions. In patients who received nimesulide and wore a wrist brace, the effectiveness of treatment was higher.

1989 ◽  
Vol 82 (6) ◽  
pp. 349-350 ◽  
Author(s):  
J S Wand

In a retrospective postal study of 27 women who have developed carpal tunnel syndrome (CTS) in the puerperium, the condition was found to affect predominantly elderly primiparous women (mean age 31.5 years). The condition was associated with breastfeeding in 24 women. The three who did not breastfeed had less severe symptoms which resolved within one month of onset. The symptoms developed a mean of 3.5 weeks following delivery, lasted 6.5 months and started to resolve within 14 days of weaning. Symptomatic treatments with either splint-age, diuretics, non-steroidal anti-inflammatory drugs or steroid injections provided some benefit. Two patients required surgical decompression. All patients were symptom-free by one year.


2017 ◽  
Vol 19 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Radoslav Zamborsky ◽  
Milan Kokavec ◽  
Lukas Simko ◽  
Martin Bohac

Carpal Tunnel Syndrome (CTS) is the most common form of entrapment neuropathy. Several authors have investigated the anatomical and pathophysiological features of CTS and have identified several parameters that, in combination, play a significant role in its pathophysiology. Advancement in biological research on CTS has enabled the advent of efficient diagnostic techniques such as provocative tests and nerve conduction studies. Sophisticated technologies, such as magnetic resonance imaging (MRI) and ultrasonography (US), have facilitated the diagnosis of CTS. This review article aims at consolidating the relevant medical literature pertaining to the symptoms, pathophysiology, clinical diagnosis and treatment strategies of CTS. It also compares the various methods of diagnosis and discusses their benefits and disadvantages. Finally, it sheds light on the conservative vs. surgical approach to treatment and compares them. While the surgical approach has proved to be more efficient relative to the conservative methods of steroid injections and splinting, many studies have demonstrated both advantages and adverse effects of the surgical methods. Surgical options and complications are discussed in detail. This article comprehensively summarizes all medical aspects of CTS to update medical professionals’ knowledge regarding the disease.


2020 ◽  
Vol 2 (2) ◽  
pp. 73
Author(s):  
Wico Hartantri ◽  
Lydia Arfianti

Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy of median nerve. The current development of global COVID-19 pandemic urges medical rehabilitation services to deliver a comprehensive approach amidst the physical distancing period. This case report aims to investigate the feasibility and efficacy of implementing telerehabilitation to the conventional therapy in the treatment of CTS. A 51-year old female presented with post carpal tunnel release of the left hand, and chronic-severe CTS on right hand. We maintained 5 weeks rehabilitation programs of combined telerehabilitation and face-to-face rehabilitation therapy and evaluation. The patient showed good compliance with the programs and achieved the intended goals within 5 weeks of therapy. Patient showed improvement (in pain, range of motions, hand functions, and ADLs). Telerehabilitation combined with conventional therapy were effective and feasible in treating patient with bilateral (left post-release and right chronic-severe) CTS. The use of telerehabilitation may add accessibility while reducing physical contact in order to minimize the risk of transmission of COVID-19.


2011 ◽  
Vol 36 (5) ◽  
pp. 788-794 ◽  
Author(s):  
Isam Atroshi ◽  
Per-Erik Lyrén ◽  
Ewald Ornstein ◽  
Christina Gummesson

Author(s):  
Imam Subadi ◽  
Hanik Hidayati ◽  
Fidiana Fidiana ◽  
Nur Sulastri

Carpal tunnel syndrome (CTS), the most common entrapment neuropathy in the upper extrimity, is a clinical syndrome characterized by a tingling sensation, numbness, pain, or weakness in the hand and wrist radiating up to the arm. This condition is a major cause of absenteeism, reduced productivity, and financial loss among various neuropathy due to median nerve compression. This paper, medical rehabilitation of CTS is viewed. Medical rehabilitation of CTS aimed to reduce pain, reduce clamping of the carpal tunnel, sensory and motor reeducation so that hand function improves and can perform activities of daily living. Treatment options can be given includes exercise therapy, ultrasound diathermy, low level laser therapy (LLLT), and shock wave therapy (SWT).


2016 ◽  
Vol 19 (02) ◽  
pp. 1650006 ◽  
Author(s):  
Francisco J. Juan-García ◽  
Jacobo Formigo-Couceiro ◽  
Manuela Barrio-Alonso ◽  
Rubén Ouviña-Arribas

Background and objectives: Carpal tunnel syndrome (CTS) is caused by compression of the median nerve as it passes through the wrist. It can be treated with both surgical and non-surgical methods. Botulinum toxin type A has been used in the treatment of spasms, dystonia, migraine relief and myofascial pain. This study is aimed at evaluating the safety and tolerability of botulinum toxin type A in carpal tunnel syndrome. Methods: We conducted an open-label, prospective study using 30 units of onabotulinum Toxin A (Botox[Formula: see text]), injected into the carpal tunnel using the in-plane ultrasound-guided ulnar approach. We used the verbal numeric rating scale (VNRS) to assess changes in pain and paraesthesias both 4 and 12 weeks following the injection. All adverse effects were recorded. Results: A total of 18 patients with 22 mild-moderate idiopathic CTS were included in the study. A total of 14 women and 4 men with a mean of age [Formula: see text] years. Botulinum toxin A was well tolerated and only one patient reported temporary subjective weakness in his/her hand muscles. Both at 4 weeks and 3 months following the injection we observed a 63.6% subjective improvement in the patients’ level of pain and paraesthesias, with no statistical significance ([Formula: see text]). Conclusion: Our study shows the effects of botulinum toxin in relieving pain and paraesthesias in carpal tunnel syndrome with moderate symptoms. The use of an in-plane ultrasound approach for its injection into the carpal tunnel adds value and safety to the procedure, and, based on our experience, is well tolerated and safe. Further studies are required to confirm these results and define optimal doses of botulinum toxin.


Hand ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Rodrigo Pires Matsuo ◽  
Carlos Henrique Fernandes ◽  
Lia Miyamoto Meirelles ◽  
Jorge Raduan Neto ◽  
João Baptista Gomes dos Santos ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
pp. 75-81
Author(s):  
Md Ruhul Kuddus ◽  
Md Omar Faruk ◽  
Samiul Alam ◽  
KM Atiqul Islam ◽  
Shamsul Alam ◽  
...  

Background: Carpal Tunnel Syndrome (CTS) is the most common form of entrapment neuropathy. Both the Medical and surgical treatments are popular in the management of CTS. The effectiveness of the surgical treatment of carpal tunnel syndrome (CTS) is well known on short term. Surgical approach has proved to be more efficient relative to the conservative methods of steroid injections and splinting. On the other hand, many studies have demonstrated both advantages and adverse effects of the surgical methods. However, limited data is available about long-term outcome after carpal tunnel release (CTR). So debate is still persists regarding Conservative vs. Surgical approach to treatment of CTS. Methods: A retrospective analysis of 15 consecutive cases performed during 1.5 year was conducted. 8 patients were treated surgically with transpalmar approach. 7 patient were treated conservatively. The criteria for treatment efficacy were improvements in symptoms, such as pain, paresthesia and recurrences after surgery. Results: Female were predominant 80% than male 20%. Right hand was more frequently affected 80% than left 20%. most paitents were diabetic except 2. outcome in the surgical group was excellent. Patient of non-surgical group was not satisfied as surgical group. Conclusions: CTR is a robust treatment for CTS and its effect persists after a period of years. CTR is the choice of treatment in case of moderate to severe form of CTS. Long term follow up and inclusion of more cases is needed for a definite conclusion. Bang. J Neurosurgery 2020; 10(1): 75-81


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