NAZARBAYEV’S ACTIVITY LEVEL REMINISCENT OF AN ELECTION CAMPAIGN

2018 ◽  
Vol 70 (050) ◽  
pp. 14-15
Author(s):  
Viktoria Panfilova
Keyword(s):  
Activity Level ◽  
Election Campaign

Specificity determinants of phosphoprotein phosphatases controlling kinetochore functions

2020 ◽  
Vol 64 (2) ◽  
pp. 325-336 ◽  
Author(s):  
Dimitriya H. Garvanska ◽  
Jakob Nilsson
Keyword(s):  
Spindle Assembly Checkpoint ◽  
Activity Level ◽  
Phosphorylation Sites ◽  
Binding Affinities ◽  
Mitotic Kinases ◽  
Anaphase Onset ◽  
Phosphoprotein Phosphatases ◽  
Linear Motifs ◽  
Temporal And Spatial ◽  
Kinetochore Function

Abstract Kinetochores are instrumental for accurate chromosome segregation by binding to microtubules in order to move chromosomes and by delaying anaphase onset through the spindle assembly checkpoint (SAC). Dynamic phosphorylation of kinetochore components is key to control these activities and is tightly regulated by temporal and spatial recruitment of kinases and phosphoprotein phosphatases (PPPs). Here we focus on PP1, PP2A-B56 and PP2A-B55, three PPPs that are important regulators of mitosis. Despite the fact that these PPPs share a very similar active site, they target unique ser/thr phosphorylation sites to control kinetochore function. Specificity is in part achieved by PPPs binding to short linear motifs (SLiMs) that guide their substrate specificity. SLiMs bind to conserved pockets on PPPs and are degenerate in nature, giving rise to a range of binding affinities. These SLiMs control the assembly of numerous substrate specifying complexes and their position and binding strength allow PPPs to target specific phosphorylation sites. In addition, the activity of PPPs is regulated by mitotic kinases and inhibitors, either directly at the activity level or through affecting PPP–SLiM interactions. Here, we discuss recent progress in understanding the regulation of PPP specificity and activity and how this controls kinetochore biology.

Self-Referent Thoughts in Exercise: The Self-Perception in Exercise Questionnaire

1997 ◽  
Vol 13 (3) ◽  
pp. 195-205 ◽  
Author(s):  
Marit Sorensen
Keyword(s):  
Physical Activity ◽  
Pilot Study ◽  
Physical Activity Level ◽  
Convergent Validity ◽  
English Language ◽  
Lifestyle Changes ◽  
Activity Level ◽  
Language Version ◽  
Social Comfort ◽  
And Gender

Adherence to lifestyle changes - beginning to exercise, for example - is assumed to be mediated by self-referent thoughts. This paper describes a pilot study and three studies conducted to develop and validate a questionnaire for adults to determine their self-perceptions related to health-oriented exercise. The pilot study identified items pertinent to the domains considered important in this context, and began the process of selecting items. Study 2 examined the factor structure, reduced the number of items, determined the internal consistency of the factors, and explored the discriminative validity of the questionnaire as to physical activity level and gender. Four factors with a total of 24 items were accepted, measuring mastery of exercise, body perception, social comfort/discomfort in the exercise setting, and perception of fitness. All subscales had acceptable internal consistencies. Preliminary validity was demonstrated by confirming hypothesized differences in scores as to gender, age, and physical activity level. The third study examined and demonstrated convergent validity with similar existing subscales. The fourth study examined an English-language version of the questionnaire, confirming the existence of the factors and providing preliminary psychometric evidence of the viability of the questionnaire.

Hypertension Self-Care Activity Level Effects

2011 ◽  
Author(s):  
Jan Warren-Findlow ◽  
Rachel B. Seymour
Keyword(s):  
Self Care ◽  
Activity Level ◽  
Care Activity

‘Restore Moscow to the Muscovites’: Othering ‘the migrants’ in the 2013 Moscow mayoral elections

2018 ◽  
Author(s):  
Helge Blakkisrud ◽  
Pål Kolstø
Keyword(s):  
Migration Policy ◽  
Election Campaign ◽  
Migrant Population ◽  
Mayoral Elections ◽  
Mayoral Election ◽  
And Migration ◽  
Russian Identity

Russia encompasses the world’s second-largest migrant population in absolute numbers. This chapter explores the role migrants play in contemporary Russian identity discourse, focusing on the topic that ordinary Muscovites identified as most important during the 2013 Moscow mayoral election campaign: the large number of labour migrants in the capital. It explores how the decision to open up the elections into a more genuine contest compelled the regime candidate, incumbent mayor Sergei Sobianin, to adopt a more aggressive rhetoric on migration than otherwise officially endorsed by the Kremlin. The chapter concludes that the Moscow electoral experiment, allowing other candidates than the regime’s own hand-picked, ‘controllable’ sparring partners to run, contributed to pushing the borders of what mainstream politicians saw as acceptable positions on migrants and migration policy.

Public space of the trustworthiness of sociological knowledge: The case of electoral research

2020 ◽  
pp. 13-22
Author(s):  
OLEKSANDR STEGNII
Keyword(s):  
Public Space ◽  
Research Process ◽  
Negative Influence ◽  
Election Campaign ◽  
Sociological Research ◽  
Good Tool ◽  
Sociological Knowledge ◽  
The Public ◽  
Approval Ratings ◽  
The Impact

The paper analyses specific features of sociological data circulation in a public space during an election campaign. The basic components of this kind of space with regard to sociological research are political actors (who put themselves up for the election), voters and agents. The latter refer to professional groups whose corporate interests are directly related to the impact on the election process. Sociologists can also be seen as agents of the electoral process when experts in the field of electoral sociology are becoming intermingled with manipulators without a proper professional background and publications in this field. In a public space where an electoral race is unfolding, empirical sociological research becomes the main form of obtaining sociological knowledge, and it is primarily conducted to measure approval ratings. Electoral research serves as an example of combining the theoretical and empirical components of sociological knowledge, as well as its professional and public dimensions. Provided that sociologists meet all the professional requirements, electoral research can be used as a good tool for evaluating the trustworthiness of results reflecting the people’s expression of will. Being producers of sociological knowledge, sociologists act in two different capacities during an election campaign: as analysts and as pollsters. Therefore, it is essential that the duties and areas of responsibility for professional sociologists should be separated from those of pollsters. Another thing that needs to be noted is the negative influence that political strategists exert on the trustworthiness of survey findings which are going to be released to the public. Using the case of approval ratings as an illustration, the author analyses the most common techniques aimed at misrepresenting and distorting sociological data in the public space. Particular attention is given to the markers that can detect bogus polling companies, systemic violations during the research process and data falsification.

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