Assessment of platelet rich plasma (PRP) therapy in prevention of chronic wound complications

2021 ◽  
Vol 2 (12) ◽  
pp. 35-39
Author(s):  
Mahmoud Shehata ◽  
Amr Rezk
Keyword(s):  
Chronic Wound ◽  
Platelet Rich Plasma ◽  
Wound Complications

scholarly journals CLINICAL AND HISTOPATHOLOGICAL EVALUATION OF USING PLATELET-RICH PLASMA AND PLATELET-RICH FIBRIN MATRIX IN TREATMENT OF INDUCED CHRONIC OPEN WOUNDS IN BUCKS

2018 ◽  
Vol 11 (5) ◽  
pp. 337 ◽  
Author(s):  
Falah H Khalaf ◽  
Serwa Ibrahim Salih
Keyword(s):  
Chronic Wound ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Experimental Period ◽  
Control Group ◽  
Full Thickness ◽  
Platelet Rich Fibrin ◽  
Fibrin Matrix ◽  
Four Square ◽  
Prp Gel

Objective: This study was designed to identify the effectiveness of platelet-rich plasma gel (PRP) and platelet-rich fibrin matrix (PRF) application on the induced open chronic full-thickness cutaneous wounds in goats.Methods: A total of 24 adult apparently healthy local breed bucks were used in this study. PRP gel and PRF matrix were prepared from whole blood at the time of treatment, four square full-thickness skin wounds (4 cm × 4 cm) on the dorsal sides of the back of each animal were created, by daily scratched to interrupt healing process continuation to prolong inflammatory reaction to form chronic wound, this surgical procedure was continued for 8 weeks to ensure the traditional chronicity wounds, after that they were treated by PRP gel in the first group (n=12), while PRF matrix was used in the second group (n=12). Each group was also subdivided into treatment (n=2 wounds) and control group (n=2 wounds) in each animal. The healing process was evaluated by clinical examination during experimental period and histologically in day 7, 14, 28, and 45 post operation.Conclusion: Both groups showed faster tissue repair and epithelialization in treatment groups compared to control groups. The results of this study confirmed PRP gel and PRF matrix application improved and accelerated cutaneous open chronic wound healing.

scholarly journals Platelet Rich Plasma Give Promising Results in Chronic Wound Healing

2020 ◽  
Vol 2 (7) ◽  
pp. 10-11
Author(s):  
Niyati Dhawan ◽  
Brajpal Singh Tyagi
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Platelet Rich Plasma

PD42 Safety And Cost-Effectiveness Of Platelet-Rich Plasma For Chronic Wounds

2018 ◽  
Vol 34 (S1) ◽  
pp. 143-144
Author(s):  
Tasmania del Pino-Sedeño ◽  
Renata Linertová ◽  
Maria M. Trujillo-Martin ◽  
Ana Toledo-Chávarri ◽  
Sybille Káiser Girardot ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cost Effectiveness ◽  
Standard Care ◽  
Chronic Wounds ◽  
Standard Treatment ◽  
Chronic Wound ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Cost Effectiveness Analysis ◽  
Effectiveness Analysis

Introduction:New therapeutic strategies have been established in chronic wound healing procedures, such as the use of platelet-rich plasma (PRP). There is currently still uncertainty about the effectiveness, cost-effectiveness and real safety of PRP in promoting chronic wound healing and what specific types of chronic wounds can benefit most from its use.Methods:We conducted a systematic review of available scientific literature on the effectiveness, safety and cost-effectiveness of PRP compared to placebo, standard care or alternative topical therapies for the treatment of chronic wounds in adults. Overall effect size was estimated through a meta-analysis. A cost-effectiveness analysis was conducted using a Markov model which simulates the costs and health outcomes of individuals for a 5-year horizon, from the perspective of the Spanish National Health Service (NHS) for the PRP versus standard treatment in patients with diabetic foot ulcers. The effectiveness measure was quality-adjusted life years (QALYs). We ran extensive sensitivity analyses, including a probabilistic sensitivity analysis.Results:Sixteen RCTs and four observational studies were included for the effectiveness and safety meta-analysis. The primary outcome was the proportion of chronic wounds completely healed: 143 patients out of 334 (42.8 percent) were cured in the standard treatment arm and 251 patients out of 375 (66.9 percent) in the PRP arm, relative risk (RR) 1.68 (95% CI: 1.22–2.31). It was unclear whether there was a difference in the risk of infection (RR 0.53, 95% CI: 0.10–2.71) or adverse events (RR 1.05, 95% CI: 0.29–3.88) between PRP and standard care. Three studies were considered for the cost-effectiveness analysis. In the base case analysis, PRP led to higher QALYs and healthcare costs with an estimated incremental cost-effectiveness ratio (ICER) of EUR 41,767 (USD 48,323)/QALY.Conclusions:PRP treatment is more expensive and more effective than standard treatment. The estimated ICER is above the acceptability threshold in Spain.

Xeno-free autologous platelet rich plasma for chronic wound management – Case series

2018 ◽  
Vol 20 ◽  
pp. 54-57
Author(s):  
Krishnaiah Kurapati ◽  
Praveen Kumar G.V. ◽  
Kavitha Anbarasu ◽  
Anand Kumar Vaggu ◽  
Vibhuda Nanduri ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Platelet Rich Plasma ◽  
Case Series ◽  
Wound Management ◽  
Autologous Platelet Rich Plasma ◽  
Chronic Wound Management ◽  
Autologous Platelet

scholarly journals Application Research of the Moist Wound Theory in Chronic Wound Nursing

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Shuying Ling
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Wound Complications ◽  
Control Group ◽  
Application Research ◽  
Significant Difference ◽  
Wound Pain ◽  
Experimental Group

Objective — To explore the application value of observation of moist wound theory in chronic wound care. Methods — From February 2019 to May 2020, a total of 96 patients with chronic wounds were treated in this hospital. The patients were divided into two groups based on the two-color ball method, with 48 cases in each group. Routine wound nursing (48 patients, the control group) and moist wound theory (48 patients, the experimental group) were used to compare the wound healing between the two groups. Results — The wound healing rate of 48 patients in the experimental group was significantly higher than that in the control group, and there was a significant difference (P<0.05). The incidence of chronic wound complications (wound pain, wound infection, tissue adhesion) of 48 patients in the experimental group was significantly lower than that in the control group, and there was a significant difference (P<0.05). Conclusion — The application of moist wound theory in chronic wound nursing can promote the rehabilitation of patients with chronic wounds, improve the rate of wound healing, reduce the incidence of complications, and improve the patients' nursing efficacy.

scholarly journals AUTOLOGOUS PLATELET - RICH PLASMA (PRP) THERAPY AND CHANGEMENTS OF TOPICAL BIOLOGICAL MARKERS (EGF, VEGF AND MMP12) OF CHRONIC WOUNDS

2021 ◽  
Vol 506 (1-2) ◽  
Author(s):  
Nguyen Ngoc Tuan ◽  
Nguyen Tran Ngoc Tu ◽  
Nguyen Tien Dung
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Wound Healing Process ◽  
Elisa Technique ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Objective: Our aim was to evaluate topical EGF, VEGF, MMP12 concentrations of ​​chronic wounds which after Autologous Platelet - Rich Plasma(PRP) therapy. Methods: The study conducted a descriptive longitudinal study at the Wound Healing Center of the Vietnam National Burn Hospital from 11/2018 to 2/2020. 24 patients with chronic wounds and aged 18 years old or older were enrolled in this study. These patients were injected autologous PRP at wound bed. We biopsied chronic wound bed tissue for evaluating EGF, VEGF and MMP12 by the Elisa technique at the first, second and third week of follow-up. Results: After PRP therapy, topical EGF and VEGF concentration increased after 1 week of treatment. MMP12 concentraiton significantly reduced compaired to before PRP therapy. Conclusion: In addition to PRP therapy had a beneficial effect on cutaneous regeneration and wound healing of the chronic wound. The autologous PRP promoted the wound healing process byincreating topical EGF and VEGF, reducing MMP12 which known as a pro-inflammatiory mediator.

Factors Associated With Acute and Chronic Wound Complications in Patients With Soft Tissue Sarcoma With Long-term Follow-up

2018 ◽  
Vol 41 (10) ◽  
pp. 1019-1023 ◽  
Author(s):  
Naveen Karthik ◽  
Matthew C. Ward ◽  
Aditya Juloori ◽  
Jacob Scott ◽  
Nathan Mesko ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Chronic Wound ◽  
Wound Complications ◽  
Factors Associated ◽  
Long Term Follow Up
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