INVESTIGATING THE EFFECT OF PROBIOTICS ON THE GUT MICROBIOME AND ON THE OUTCOME OF FOLFOX CHEMOTHERAPY IN COLORECTAL CANCER PATIENTS

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Sarah Obuya
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Folfox Chemotherapy ◽  
Colorectal Cancer Patients

scholarly journals Gut microbiome of Moroccan colorectal cancer patients

2018 ◽  
Vol 207 (3-4) ◽  
pp. 211-225 ◽  
Author(s):  
Imane Allali ◽  
Noureddine Boukhatem ◽  
Leila Bouguenouch ◽  
Hanaa Hardi ◽  
H. Abir Boudouaya ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Colorectal Cancer Patients

scholarly journals Adjusting for age improves identification of gut microbiome alterations in multiple diseases

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Tarini S Ghosh ◽  
Mrinmoy Das ◽  
Ian B Jeffery ◽  
Paul W O'Toole
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Gut Microbiome ◽  
Age Groups ◽  
Elderly Subjects ◽  
Middle Aged ◽  
Disease Response ◽  
Disease Associations ◽  
Colorectal Cancer Patients ◽  
Disease Signatures

Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-microbiome associations display specific age-centric trends. Ageing-associated microbiome alterations towards a disease-like configuration occur in colorectal cancer patients, thereby masking disease signatures. We identified a microbiome disease response shared across multiple diseases in elderly subjects that is distinct from that in young/middle-aged individuals, but also a novel set of taxa consistently gained in disease across all age groups. A subset of these taxa was associated with increased frailty in subjects from the ELDERMET cohort. The relevant taxa differentially encode specific functions that are known to have disease associations.

scholarly journals Overweight is associated with better prognosis in metastatic colorectal cancer patients treated with bevacizumab plus FOLFOX chemotherapy

2020 ◽  
Vol 24 (1) ◽  
pp. 34-41
Author(s):  
Bożena Cybulska-Stopa ◽  
Iwona Ługowska ◽  
Rafał Wiśniowski ◽  
Małgorzata Domagała-Haduch ◽  
Marcin Rajczykowski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Folfox Chemotherapy ◽  
Colorectal Cancer Patients
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