Evaluation of Serum Levels of High-Mobility Group Box 1 Protein in Acne Vulgaris

High-mobility group protein box-1 (HMGB1) is a proinflammatory involved in many inflammatory diseases. However, its roles in intracerebral hemorrhage (ICH) remain unknown. The purpose of this study was to examine the correlation between changes in serum levels of HMGB1 following acute ICH and the severity of stroke as well as the underlying mechanism. Changes in serum levels of HMGB1 in 60 consecutive patients with primary hemispheric ICH within 12 hours of onset of symptoms were determined. The correlation of HMGB1 with disease severity, IL-6, and TNF-αwas analyzed. Changes in HMGB1 levels were detected with ELISA and Western blot. Compared with normal controls, patients with ICH had markedly elevated levels of HMGB1, which was significantly correlated with the levels of IL-6 and TNF-α, NIHSS score at the 10th day, and mRS score at 3 months. In comparison with the control group, the levels of HMGB1 in the perihematomal tissue in mice with ICH increased dramatically, peaked at 72 hours, and decreased at 5 days. Meanwhile, heme could stimulate cultured microglia to release large amounts of HMGB1 whereasFe2+/3+ions failed to stimulate HMGB1 production from microglia. Our findings suggest that HMGB1 may play an essential role in the ICH-caused inflammatory injury.

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Diagnostic value of matrix metalloproteinase-2 and high mobility group box 1 in patients with refractory epilepsy

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00235-7 ◽

2020 ◽

Vol 56 (1) ◽

Author(s):

Khalid S. Salih ◽

Farqad B. Hamdan ◽

Qasim S. Al-Mayah

Keyword(s):

Roc Curve ◽

Refractory Epilepsy ◽

High Mobility ◽

Serum Levels ◽

Diagnostic Value ◽

High Mobility Group ◽

Matrix Metalloproteinase 2 ◽

Hmgb1 Level ◽

Epileptic Patients ◽

Serum Hmgb1 Level

Abstract Introduction There are large numbers of inflammatory molecules and humoral mediators that can be involved in the epileptogenesis such as cytokines, matrix metalloproteinases (MMP), and high mobility group box-1 (HMGB1). We aimed to evaluate serum levels and the diagnostic value of MMP-2 and HMGB1 in Iraqi patients with epilepsy. Methods One hundred epileptic patients comprised 60 controlled epileptics and 40 refractory patients to treatment with multi antiepileptic drugs (AEDs). Other 50 family-unrelated age- and sex-matched healthy subjects were selected to represent the control group. Serum levels of MMP-2 and HMGB1 were estimated using ELISA. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of these markers when required. Results MMP-2 level was significantly higher in controls than epileptic patients in general (controlled and refractory patients). ROC curve, showed poor diagnostic value of MMP-2 in discriminating epileptics into responsive or refractory to treatment from controls (AUC = 0.679 (95% CI = 0.536-0.823), and AUC = 0.77 (95% CI = 0.637-902), respectively). Serum HMGB1 level in epileptic patients and controls was in close approximation to each other. Conclusions MMP-2 is significantly decreased in patients particularly those with refractory epilepsy (RE); however, it has poor diagnostic value. No difference in the serum HMGB1 level between epileptic patients and controls.

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Retracted: Correlation between Serum Levels of High Mobility Group Box-1 Protein and Pancreatitis: A Meta-Analysis

BioMed Research International ◽

10.1155/2019/5190178 ◽

2019 ◽

Vol 2019 ◽

pp. 1-1

Keyword(s):

Meta Analysis ◽

High Mobility ◽

Serum Levels ◽

High Mobility Group

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High mobility group box 1 serum levels are increased in Behçet’s disease, but not associated with disease activity or disease manifestations

Rheumatology ◽

10.1093/rheumatology/kev202 ◽

2015 ◽

pp. kev202 ◽

Cited By ~ 1

Author(s):

Alexandre W. S. de Souza ◽

Sandro Félix Perazzio ◽

Natália Regine de França ◽

Luis Eduardo C. Andrade ◽

Marc Bijl ◽

...

Keyword(s):

Disease Activity ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

High Mobility ◽

Serum Levels ◽

High Mobility Group ◽

Behcet's Disease

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Increased serum levels of high mobility group box 1 protein in patients with autistic disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2010.03.020 ◽

2010 ◽

Vol 34 (4) ◽

pp. 681-683 ◽

Cited By ~ 19

Author(s):

Enzo Emanuele ◽

Marianna Boso ◽

Natascia Brondino ◽

Stefania Pietra ◽

Francesco Barale ◽

...

Keyword(s):

Autistic Disorder ◽

High Mobility ◽

Serum Levels ◽

High Mobility Group

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Correlation between Serum Levels of High Mobility Group Box-1 Protein and Pancreatitis: A Meta-Analysis

BioMed Research International ◽

10.1155/2015/430185 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Yan Lin ◽

Lian-Jie Lin ◽

Yu Jin ◽

Yong Cao ◽

Ying Zhang ◽

...

Keyword(s):

Meta Analysis ◽

High Mobility ◽

Serum Levels ◽

High Mobility Group ◽

Cochrane Library ◽

Case Control Studies ◽

Aberrant Expression ◽

Hmgb1 Level ◽

Diagnostic Score ◽

Standard Mean Difference

Background. Aberrant expression of high mobility group box-1 protein (HMGB1) contributes to the progression of various inflammatory diseases. This meta-analysis focused on the clinical significance of serum HMGB1 levels in pancreatitis patients, with the goal of building a novel diagnostic score model.Method. We conducted a meta-analysis by searching in the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases without any language restrictions. Studies were pooled and standard mean difference (SMD) and its corresponding 95% confidence intervals (95% CIs) were calculated. Version 12.0 STATA software was used for statistical analysis.Results. We performed a final analysis of 841 subjects from 12 clinical case-control studies. The meta-analysis results showed a positive association between serum HMGB1 levels and the progression of pancreatitis. In the subgroup analysis by country, high serum level of HMGB1 may be related to pancreatitis progression in China, Korea, Hungary, and Japan populations (allP<0.05).Conclusion. The present meta-analysis indicated that serum HMGB1 level was statistically elevated in patients with pancreatitis, and thus serum levels of HMGB1 could be determined to be a useful biomarker for pancreatitis patients.

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