Comparative Study Between Vaginal Natural Progesterone and Oral Dydrogesteron in Preventinon of Red Degeneration of Uterine Fibroid in Pregnancy.

Background: Uterine leiomyomas are highly prevalent benign monoclonal tumors, arising from the smooth muscle of the myometrium; they occur in up to 50-60% of reproductive age women, causing significant morbidity in up to 30% of women. The most serious complication of uterine fibroids; is red degeneration that causes severe pain, and may lead to preterm labour, miscarriage, fetal and maternal morbidity and mortality. Objective of this study was designed to compare between the effect of vaginal natural MP and oral dydrogesterone in prevention of red degeneration of uterine fibroid during pregnancy.Methods: Patients were recruited from El-Shatby Maternity University Hospital. They were 50 pregnant females, diagnosed having a uterine fibroid more than 3 cm in size then there were divided into two groups, Group A: twenty-five treated by vaginal natural progesterone, Group B: twenty-five treated by oral dydrogesterone. All patients at 14-15 weeks of gestational age underwent complete history taking, clinical examination and ultrasound examination for mean gestational age and assessment of the type and uterine fibroid.Results: Results showed that there were no statistically significant differences as regards age, obstetric history (gravidity and parity), number, Site, grade and size of the fibroid. There was a significant difference between the two studied groups, regarding the acute abdominal pain, it occurred to only 3 cases (12%) in Group A, versus to 16 cases (64%) in Group B. Regarding occurrence of red degeneration, it occurred only to 3 cases (12%) in Group A, while in Group B it occurred to 15 cases (60%).Conclusions: Vaginal natural micronized progesterone is more effective than oral dydrogesterone in prevention of red degeneration of uterine fibroid in pregnancy with fewer complications. Vaginal natural progesterone daily dose of 200 mg is recommended to all pregnant females with uterine fibroids.

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Physiopathology and Management of Uterine Fibroids

10.5772/intechopen.94162 ◽

2020 ◽

Author(s):

Joel Noutakdie Tochie ◽

Therese Gaelle Badjand ◽

Gregory Ayissi ◽

Julius Sama Dohbit

Keyword(s):

Urinary Incontinence ◽

Pregnant Woman ◽

Menstrual Cycle ◽

Uterine Fibroid ◽

Uterine Fibroids ◽

Reproductive Age ◽

Heavy Menstrual Bleeding ◽

Spontaneous Abortions ◽

Red Degeneration ◽

In Pregnancy

Uterine fibroid is the most encountered benign tumour in women of reproductive age. It causes spontaneous abortions, missed abortions, painful red degeneration or infarction of the fibroids, abnormal foetal presentation, obstructed labour, and an increased likelihood of premature deliveries, caesarean deliveries, postpartum haemorrhage in pregnancy, whereas, in the non-pregnant women it is associated an irregular menstrual cycle sometimes associated with heavy menstrual bleeding, infertility, constipation, urinary incontinence, and leiosarcoma transformation. Till date is pathophysiology and management both in the non-pregnant and pregnant woman have not been well described. In this chapter, we present contemporary evidence to help elucidate this enigma.

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A COMPARATIVE STUDY OF IODINE METABOLISM IN PREGNANCY, SPORADIC GOITRE AND THYROTOXICOSIS

Acta Endocrinologica ◽

10.1530/acta.0.0480014 ◽

1965 ◽

Vol 48 (1) ◽

pp. 14-22 ◽

Cited By ~ 3

Author(s):

S. A. Aboul-Khair ◽

J. Crooks

Keyword(s):

Comparative Study ◽

Pregnant Women ◽

Iodine Deficiency ◽

Physiological Responses ◽

Iodine Uptake ◽

Thyroid Activity ◽

Deficiency State ◽

Iodine Metabolism ◽

Inorganic Iodine ◽

In Pregnancy

ABSTRACT Studies of iodine metabolism have been carried out in 15 pregnant women, 33 cases with sporadic goitre and 11 with thyrotoxicosis. A low plasma inorganic iodine was common to the three groups. In pregnancy and sporadic goitre the thyroid clearance of iodine was elevated and the absolute iodine uptake normal. A high thyroid clearance of iodine in thyrotoxicosis was associated with a high absolute iodine uptake. The results suggest that both pregnancy and sporadic goitre are physiological responses to an iodine deficiency state while the iodine deficiency state of thyrotoxicosis is secondary to increased thyroid activity.

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Comparative study of conservative and surgical management for symptomatic moderate and severe hydronephrosis in pregnancy: a prospective randomized study

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1080/00016340701416713 ◽

2007 ◽

Vol 86 (9) ◽

pp. 1047-1050 ◽

Cited By ~ 15

Author(s):

Yieh-Loong Tsai ◽

Kok-Min Seow ◽

Chung-Hsin Yieh ◽

Kian-Mei Chong ◽

...

Keyword(s):

Comparative Study ◽

Surgical Management ◽

Randomized Study ◽

Prospective Randomized Study ◽

In Pregnancy

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A Comparative Study of Serum Progesterone Levels in Pregnancy and in Various Types of Pseudopregnancy in the Rat1

Endocrinology ◽

10.1210/endo-95-1-275 ◽

1974 ◽

Vol 95 (1) ◽

pp. 275-279 ◽

Cited By ~ 129

Author(s):

G. J. PEPE ◽

I. ROTHCHILD

Keyword(s):

Comparative Study ◽

Serum Progesterone ◽

In Pregnancy

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Huge symptomatic pedunculated uterine fibroid in pregnancy: Antepartum myomectomy and term delivery at a specialist hospital in Kano, Nigeria

Annals of African Medical Research ◽

10.4081/aamr.2020.86 ◽

2021 ◽

Vol 3 (2) ◽

Author(s):

Iman Usman Haruna ◽

Jamilu Tukur ◽

Idris Usman Takai ◽

Abdullahi Mustapha Miko Mohammed ◽

Ali Abdurrahman Bunawa

Keyword(s):

Caesarean Section ◽

Acute Abdomen ◽

Live Birth ◽

Uterine Fibroid ◽

Recent Literature ◽

Caesarian Section ◽

Term Delivery ◽

In Pregnancy

Myomas are common in pregnancy and can go unnoticed. One in ten patients, however, develops complications that would necessitate their removal. Myomectomy performed at caesarian section had come to the lime light over the last decade and recent literature have shown its safety. There is still paucity of literature on myomectomy performed during pregnancy. Our case was a 25 years old primigravida at 21 weeks with features of acute abdomen secondary to uterine fibroid which was diagnosed during pregnancy. She subsequently had antepartum myomectomy and a live birth at term via caesarean section.

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