Assessment of Platelet Rich Plasma Injection on Muscle Spindle Injury in a Rat Model (Histological and Immunohistochemical study)

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yasmin Ramadan ◽  
Ahmed Desouky ◽  
Marwa El Sawy
Keyword(s):  
Muscle Spindle ◽  
Rat Model ◽  
Immunohistochemical Study ◽  
Platelet Rich Plasma ◽  
Plasma Injection

Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study

2017 ◽  
Vol 151 (1) ◽  
pp. 92-104 ◽  
Author(s):  
Ayşegül Güleç ◽  
Banu Çakırer Bakkalbaşı ◽  
Alev Cumbul ◽  
Ünal Uslu ◽  
Burçin Alev ◽  
...  
Keyword(s):  
Rat Model ◽  
Tooth Movement ◽  
Platelet Rich Plasma ◽  
Orthodontic Tooth Movement ◽  
Histomorphometric Study ◽  
Plasma Injection

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

Arthroscopic Debridement Versus Platelet Rich Plasma Injection in Treatment of Moderate knee Osteoarthritis.

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yousef El Shahat Abo El Fadl ◽  
Riad Megahed ◽  
Mohammed Abdel Fattah ◽  
Mohamed Nasef
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Arthroscopic Debridement ◽  
Plasma Injection
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