The Role of Serum Neuron Specific Enolase in Detecting Preoperative Brain Injury in Infants and Toddlers with Congenital Heart Disease

AbstractPatients with congenital heart disease (CHD) are at risk for developing intestinal dysbiosis and intestinal epithelial barrier dysfunction due to abnormal gut perfusion or hypoxemia in the context of low cardiac output or cyanosis. Intestinal dysbiosis may contribute to systemic inflammation thereby worsening clinical outcomes in this patient population. Despite significant advances in the management and survival of patients with CHD, morbidity remains significant and questions have arisen as to the role of the microbiome in the inflammatory process. Intestinal dysbiosis and barrier dysfunction experienced in this patient population are increasingly implicated in critical illness. This review highlights possible CHD-microbiome interactions, illustrates underlying signaling mechanisms, and discusses future directions and therapeutic translation of the basic research.

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Role of coxsackie‐adenovirus receptor in cardiac development and pathogenesis of congenital heart disease

Birth Defects Research ◽

10.1002/bdr2.1860 ◽

2020 ◽

Author(s):

Vipul Sharma ◽

Daniel J. Perry ◽

Pirooz Eghtesady

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Cardiac Development ◽

Coxsackie Adenovirus Receptor ◽

Adenovirus Receptor

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Brain Injury in Infants with Critical Congenital Heart Disease: Insights from Two Clinical Cohorts with Different Practice Approaches

The Journal of Pediatrics ◽

10.1016/j.jpeds.2019.07.017 ◽

2019 ◽

Vol 215 ◽

pp. 75-82.e2 ◽

Cited By ~ 3

Author(s):

Nathalie H.P. Claessens ◽

Vann Chau ◽

Linda S. de Vries ◽

Nicolaas J.G. Jansen ◽

Stephanie H. Au-Young ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Brain Injury ◽

Congenital Heart ◽

Critical Congenital Heart Disease

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The role of EEG recordings in children undergoing cardiac surgery for congenital heart disease

Wiener Medizinische Wochenschrift ◽

10.1007/s10354-017-0576-0 ◽

2017 ◽

Vol 167 (11-12) ◽

pp. 251-255

Author(s):

Sascha Meyer ◽

Martin Poryo ◽

Mohammed Shatat ◽

Ludwig Gortner ◽

Hashim Abdul-Khaliq

Keyword(s):

Congenital Heart Disease ◽

Cardiac Surgery ◽

Heart Disease ◽

Congenital Heart ◽

Eeg Recordings

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Role of Oxidative Damage and Myocardial Cell Injuries in Human Severe Sepsis/Septic Shock after Surgical Correction of Congenital Heart Disease in Infants

Pediatric Research ◽

10.1038/pr.2011.492 ◽

2011 ◽

Vol 70 ◽

pp. 267-267

Author(s):

M S Oliveira ◽

E Z Martinez ◽

L C Peres ◽

W V A Vicente ◽

E M Floriano ◽

...

Keyword(s):

Septic Shock ◽

Congenital Heart Disease ◽

Severe Sepsis ◽

Heart Disease ◽

Oxidative Damage ◽

Congenital Heart ◽

Myocardial Cell ◽

Surgical Correction

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Extracorporeal membrane oxygenation and cyanotic congenital heart disease

Cardiology in the Young ◽

10.1017/s1047951100007940 ◽

1992 ◽

Vol 2 (4) ◽

pp. 359-360 ◽

Cited By ~ 2

Author(s):

Gale A. Pearson ◽

Richard K. Firmin ◽

Ranjit Leanage

Keyword(s):

Congenital Heart Disease ◽

United Kingdom ◽

Heart Disease ◽

Extracorporeal Membrane Oxygenation ◽

Congenital Heart ◽

Cyanotic Congenital Heart Disease ◽

Membrane Oxygenation ◽

The United Kingdom

AbstractWorldwide figures suggest that two percent of appropriate referrals for neonatal extracorporeal membrane oxygenation turn out to have previously covert congenital heart disease. This is despite the fact that expert cardiological evaluation is routine prior to cannulation. The experience in the United Kingdom includes such a case which is reported here. The implications for the role of pediatric cardiologists in such a service are considered.

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ABNORMAL CAPILLARY MORPHOLOGY IN CONGENITAL HEART DISEASE

PEDIATRICS ◽

10.1542/peds.37.2.316 ◽

1966 ◽

Vol 37 (2) ◽

pp. 316-322

Author(s):

Stella B. Kontras ◽

JoAnn G. Bodenbender

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Septal Defect ◽

Chronic Hypoxia ◽

Normal Children ◽

Vascular Abnormalities ◽

Definitive Surgery ◽

Vascular Compartment

Capillary morphology has been studied in 111 normal children. In 98% of these cases, straight hairpin forms make up over 80% of the capillaries examined. Thirty children with congenital heart disease showed 80% abnormal capillary patterns consisting of dilated, tortuous, and branched loops. These were most marked in cyanotic tetralogy of Fallot and ventricular septal defect with pulmonary hypertension. These cases also were associated with microscopic hemorrhages, increased capillary fragility and actual postoperative hemorrhagic complications. Definitive surgery in two cases, though improving the patient, did not result in changes in the abnormal capillary patterns. It is suggested that the role of the capillary structure in rheology of blood in the microvasculature has largely been ignored and that abnormalities in this vascular compartment may affect perfusion of tissues. The association of abnormalities in coagulation studies, hemorrhage, and thrombosis with congenital heart disease may in part be related to the morphologic vascular abnormalities. The abnormal capillary findings may be due to maturational arrest or dysmaturity of this portion of the cardiovascular system or may be the result of chronic hypoxia.

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The role of the atria in congenital heart disease

Cardiology Clinics ◽

10.1016/s0733-8651(02)00006-1 ◽

2002 ◽

Vol 20 (3) ◽

pp. 351-366 ◽

Cited By ~ 2

Author(s):

Folkert Meijboom ◽

Jolien Roos-Hesselink ◽

Horst Sievert

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart

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Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease

Journal of Perioperative Echocardiography ◽

10.5005/jp-journals-10034-1025 ◽

2014 ◽

Vol 2 (2) ◽

pp. 68-70

Author(s):

Sandeep Singh Rana ◽

Balbir Kumar ◽

Sethu Madhavan J

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Diagnostic Accuracy ◽

Multimodal Imaging ◽

Congenital Heart ◽

Heart Diseases ◽

Associated Lesions ◽

Cardiac Lesions ◽

Intraoperative Period

ABSTRACT Complex congenital heart diseases (CHD) often present as multiple cardiac lesions. The presence of one anomaly should stimulate the physician to perform a comprehensive assessment and look for other associated anomalies.1 Multimodal imaging may be necessary to diagnose such associated lesions as single imaging may occasionally miss them. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are complimentary to each other. Routine use of TEE during intraoperative period may help us to refine diagnosis, detect the missing components and guide effective surgical repair. We present one such case where diagnosis and management were optimized by multimodal imaging. How to cite this article Kumar B, Madhavan JS, Puri GD, Rana SS. Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease. J Perioper Echocardiogr 2014;2(2):68-70.

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