Therapeutic Role of Quercetin against Experimentally Induced Hepatocellular Carcinoma in Female Albino Rats and their offspring

2021 ◽  
Vol 0 (0) ◽  
pp. 176-197
Author(s):  
Asma Abdeltawab ◽  
Hassan Elsyyad ◽  
Karoline Abdelaziz ◽  
Abd El-Fattah El-Beltagy
Keyword(s):  
Hepatocellular Carcinoma ◽  
Albino Rats ◽  
Therapeutic Role ◽  
Experimentally Induced

scholarly journals The Possible Role of Mesenchymal Stem Cells Therapy in the Repair of Experimentally Induced Colitis in Male Albino Rats

2013 ◽  
Vol 6 (2) ◽  
pp. 92-103 ◽  
Author(s):  
Sohair Ahmed Fawzy ◽  
Rahma Kamal El-din Abo-Elnou ◽  
Dalia Fathy Abd-El-Maksoud El-Deeb ◽  
Marwa Mohamed Yousry Abd-Elkader
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Albino Rats ◽  
Stem Cells Therapy ◽  
Experimentally Induced

scholarly journals Nanocurcumin Improves the Therapeutic Role of Mesenchymal Stem Cells in Liver Fibrosis Rats

2021 ◽  
Vol 11 (6) ◽  
pp. 14463-14479
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Fibrosis ◽  
Therapeutic Agent ◽  
Albino Rats ◽  
Therapeutic Role ◽  
Recovery Group ◽  
Wistar Albino Rats ◽  
Promising Therapeutic Agent

Nano-curcumin (Nano-Cur) is a promising therapeutic agent that has a wide array of effective medicinal potentials. Therefore, the present inquiry aimed to assess Nano-Cur's impact on the therapeutic effect of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in the rat model of liver fibrosis prompted by carbon tetrachloride (CCl4). Liver fibrosis was developed in 30male Wistar albino rats which were divided into five groups, six animals each. The 1st group (CCl4 group) was sacrificed immediately after the induction of liver fibrosis. The 2nd group received a single iv injection of BM-MSCs and left for 4weeks, the3rd group received 100mg/kg b.w. Nano-Cur 3times/week for 4weeks, the 4th group received a single iv injection of 107 BM-MSCs accompanied with Nano-Cur 3times/week for 4weeks, and the 5th group left for 4weeks without any intervention. Data revealed that treatment with BM-MSCs plus Nano-Cur alleviated liver fibrosis through reducing liver oxidative stress and restoring both liver histological picture and enzymatic profile. Additionally, companied treatment resulted in reducing TGFβ1 levels and attenuating the expression of Smad 2,3 and collagen I, III genes. Conversely, most of the pathological lesions were still detected in the recovery group. Nano-Cur improves the therapeutic role of BM-MSCs in liver fibrosis rats.

scholarly journals Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

2019 ◽  
Vol 9 ◽  
Author(s):  
Li Che ◽  
Panagiotis Paliogiannis ◽  
Antonio Cigliano ◽  
Maria G. Pilo ◽  
Xin Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Human Hepatocellular Carcinoma ◽  
Therapeutic Role
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