scholarly journals Exploring the Potential Role of Chemopreventive Agent, Hesperetin Conjugated Pegylated Gold Nanoparticles in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Male Wistar Albino Rats

2015 ◽  
Vol 31 (2) ◽  
pp. 171-184 ◽  
Author(s):  
Krishnan Gokuladhas ◽  
Subramaniyan Jayakumar ◽  
Balan Rajan ◽  
Ramasamy Elamaran ◽  
Chengalvarayan Subramani Pramila ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gold Nanoparticles ◽  
Potential Role ◽  
Albino Rats ◽  
Chemopreventive Agent ◽  
Wistar Albino Rats

Potential Chemopreventive role of Boldine against Hepatocellular Carcinoma via modulation of Cell Cycle Proteins in Rat Model

2021 ◽  
Vol 21 ◽  
Author(s):  
Nirmala Subramaniam ◽  
Pugazhendhi Kannan ◽  
Jagan Sundaram ◽  
Ashok Mari ◽  
Sathesh K. Velli ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Albino Rats ◽  
Oxygen Species ◽  
Cyclin E1 ◽  
Chemopreventive Agent ◽  
Regulated Expression ◽  
Proliferative Markers ◽  
Wistar Albino Rats ◽  
Phase I And Ii

Background: To evaluate the chemopreventive potential of boldine against diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in wistar albino rats. Objective: Boldine is an alkaloid isolated from Peumus boldus. The primary active constituents of boldine exhibited several potential medicinal properties. The present study was evaluated to explore the chemopreventive agent of boldine on anti-proliferative efficacy against diethylnitrosamine (DEN) induced hepatocellular carcinoma (HCC) in wistar albino rats. Methods: The effect of boldine on cellular proliferative markers, i.e., PCNA and Ki67 on hepatocellular carcinoma rats was determined by immuno expression study. Liver marker enzymes, tumor biomarker, oxidative stress markers, anti-oxidant status and xenobiotic phase I and II enzymes in HCC rats were analyzed. Moreover, cell cycle proteins, i.e., p21Cip1/Kip1, p27 Cip1/Kip1, Cyclin D1, CDK 4, Cyclin E1, and CDK 2 were investigated using immuno expression analysis. Results: Treatment of boldine protected the liver against reactive oxygen species such as hydrogen peroxide, superoxide, protein carbonyl and lipid peroxide during hepatocarcinogenesis by boosted antioxidants-superoxide dismutase (SOD), catalase (CAT). Boldine caused substantial enhanced detoxification process by moderating phase I and II xenobiotic metabolizing enzymes. In addition, the study was found that boldine significantly inhibited the cellular proliferative markers like PCNA and Ki67 and regulated the specific cell cycle associated proteins by up-regulated expression of p21Cip1/Kip1 and p27 Cip1/Kip1 and down-regulated expression of Cyclin D1, CDK 4, Cyclin E1, and CDK 2. Conclusion: Our data manifests the anti-proliferative effect of boldine, which negatively modulates cellular proliferation and regulates cell cycle by protecting the cell from reactive oxygen species (ROS), suggesting that boldine establish it as a chemopreventive agent in diethylnitrosamine-induced hepatocarcinogenesis in rats.

Potential role of vitamin K2as a chemopreventive agent against hepatocellular carcinoma

2007 ◽  
Vol 37 (s2 Fourth JSH S) ◽  
pp. S303-S307 ◽  
Author(s):  
Akihiro Tamori ◽  
Daiki Habu ◽  
Susumu Shiomi ◽  
Shoji Kubo ◽  
Shuhei Nishiguchi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Potential Role ◽  
Chemopreventive Agent

Potential role of vitamin D in restoring sensitivity to mTOR inhibitors in hepatocellular carcinoma (HCC): 1,25(OH)vitamin D (VitD) reverts everolimus (EVE) resistance in a hcc cell line

2017 ◽  
Author(s):  
Claudia Pivonello ◽  
Donatella Paola Provvisiero ◽  
Mariarosaria Negri ◽  
Gilda Di Gennaro ◽  
Angelis Cristina de ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Cell Line ◽  
Potential Role ◽  
Mtor Inhibitors

The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

2014 ◽  
Vol 38 (3) ◽  
pp. 774-782 ◽  
Author(s):  
Merve Bacanlı ◽  
Sevtap Aydın ◽  
Gökçe Taner ◽  
Hatice Gül Göktaş ◽  
Tolga Şahin ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Ferulic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Wistar Albino Rats

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

scholarly journals Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1110-1111 ◽  
Author(s):  
Emeric Limagne ◽  
Vanessa Cottet ◽  
Alexia Karen Cotte ◽  
Samia Hamza ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Potential Role ◽  
The Impact ◽  
Carcinoma Risk

Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats

2020 ◽  
Vol 113 ◽  
pp. 104622 ◽  
Author(s):  
Shahenda Mahgoub ◽  
Anas O. Sallam ◽  
Hazem K.A. Sarhan ◽  
Amal A.A. Ammar ◽  
Sameh H. Soror
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals ROLE OF OCIMUM CANUM IN PREVENTION OF REPERFUSION-INDUCED RENAL ISCHEMIA IN WISTAR ALBINO RATS

2012 ◽  
Vol 3 (7) ◽  
Author(s):  
Saiprasanna Behera ◽  
S M Babu ◽  
Y Roja Ramani ◽  
Prasanta Kumar Choudhury ◽  
Sudeep Kumar Patra
Keyword(s):  
Renal Ischemia ◽  
Albino Rats ◽  
Wistar Albino Rats
Sign in / Sign up

Export Citation Format

Share Document